Superparamagnetic iron oxide-enhanced interstitial magnetic resonance lymphography to detect a sentinel lymph node in tongue cancer patients

Abstract

The SNs were clearly visualized in the 10 min interstitial MR lymphography images and were completely concordant with those visualized by (99m)Tc-radiocolloid lymphoscintigraphy and a gamma probe in all cases. Iron incorporation into the SNs was confirmed by pathological examination.

Pre-operative sentinel lymph node localization in breast cancer with superparamagnetic iron oxide MRI: the SentiMAG Multicentre Trial imaging subprotocol

“…Several animal and patient studies with SPIO MRI have been performed to improve pre-operative localization of SLNs to provide a surgical roadmap. [11][12][13][14][15] However, these studies still rely on the use of radioisotopes for intraoperative detection of the sentinel nodes. Shiozawa et al 16 was the first to present an entirely radioisotope-free procedure, using SPIO MRI for pre-operative localization and a handheld magnetometer for intraoperative detection of SLNs.…”

“…However, all these studies still rely on the use of radioisotopes for intraoperative detection of the sentinel nodes. [11][12][13][14][15] To date, only one study 16 has involved both pre-operative SPIO MRI and intraoperative SLN detection with a handheld magnetometer in nine patients. However, this study did not compare the MRI technique with the gold standard of the combined technique.…”

Magnetic resonance sentinel lymph node imaging and magnetometer-guided intraoperative detection in prostate cancer using superparamagnetic iron oxide nanoparticles

“…13 Animal and human studies demonstrated that MRI after interstitial injection of SPION can be used as an alternative approach to lymphoscintigraphy for preoperative SLN evaluation. [14][15][16][17] In animal studies, the feasibility of MRI SLN imaging with gadofosveset trisodium-albumin and ferumoxytol as an intraprostatic contrast agent was shown. 18,19 A Phase I study of ferumoxytol for MR lymphography in PCa patients was carried out.…”

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

“…Mizokami et al (59) reported a study on sentinel node detection by interstitial MR lymphography with Resovist ® in tongue cancer patients who also underwent lymphoscintigraphy. The sentinel nodes were clearly visualized in the 10 min interstitial MR lymphography images and were completely concordant with those visualized by (99m) Tc-radiocolloid lymphoscintigraphy and a gamma probe in all cases.…”