Superparamagnetic core–shell electrospun scaffolds with sustained release of IONPs facilitating <i>in vitro</i> and <i>in vivo</i> bone regeneration

Hu, Shuying; Chen, Hanbang; Zhou, Fang; Li, Jun; Qian, Yunzhu; Hu, Ke; Yan, Jia; Gu, Zhuxiao; Guo, Zhaobin; Zhang, Feimin; Gu, Ning

doi:10.1039/d1tb01261d

Cited by 8 publications

(8 citation statements)

References 64 publications

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“…The carbon nanotubes positively affected cell adhesion, according to preliminary research conducted with an osteoblastic cell line. In another study, Hu et al [ 176 ] used poly (lactic-co-glycolic acid)/polycaprolactone/beta-tricalcium phosphate (PPT) scaffolds in another study with γ-Fe 2 O 3 encapsulation. The γ-Fe 2 O 3 scaffolds were coated with polyglucose sorbitol carboxymethyl ether.…”

Section: Tissue Engineering Applications Of Fe 2 O...mentioning

confidence: 99%

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

et al. 2022

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Nanomaterials have demonstrated a wide range of applications and recently, novel biomedical studies are devoted to improving the functionality and effectivity of traditional and unmodified systems, either drug carriers and common scaffolds for tissue engineering or advanced hydrogels for wound healing purposes. In this regard, metal oxide nanoparticles show great potential as versatile tools in biomedical science. In particular, iron oxide nanoparticles with different shape and sizes hold outstanding physiochemical characteristics, such as high specific area and porous structure that make them idoneous nanomaterials to be used in diverse aspects of medicine and biological systems. Moreover, due to the high thermal stability and mechanical strength of Fe2O3, they have been combined with several polymers and employed for various nano-treatments for specific human diseases. This review is focused on summarizing the applications of Fe2O3-based nanocomposites in the biomedical field, including nanocarriers for drug delivery, tissue engineering, and wound healing. Additionally, their structure, magnetic properties, biocompatibility, and toxicity will be discussed.

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Section: Tissue Engineering Applications Of Fe 2 O...mentioning

confidence: 99%

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

et al. 2022

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“…In vitro biocompatibility studies showed that the incorporation of MNPs was beneficial for the viability, proliferation, and differentiation of WJMSCs. Recent reports indicate that static magnetic fields not only enhance cell viability but also stimulate bone formation in vitro and in vivo [ 55 , 56 ]. From the above results, it can be reasonably inferred that MNPs can be regarded as a single magnetic domain that provides an intrinsic nanoscale magnetic field [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic Effect of Static Magnetic Fields and 3D-Printed Iron-Oxide-Nanoparticle-Containing Calcium Silicate/Poly-ε-Caprolactone Scaffolds for Bone Tissue Engineering

Kao

Lin

et al. 2022

Cells

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In scaffold-regulated bone regeneration, most three-dimensional (3D)-printed scaffolds do not provide physical stimulation to stem cells. In this study, a magnetic scaffold was fabricated using fused deposition modeling with calcium silicate (CS), iron oxide nanoparticles (Fe3O4), and poly-ε-caprolactone (PCL) as the matrix for internal magnetic sources. A static magnetic field was used as an external magnetic source. It was observed that 5% Fe3O4 provided a favorable combination of compressive strength (9.6 ± 0.9 MPa) and degradation rate (21.6 ± 1.9% for four weeks). Furthermore, the Fe3O4-containing scaffold increased in vitro bioactivity and Wharton’s jelly mesenchymal stem cells’ (WJMSCs) adhesion. Moreover, it was shown that the Fe3O4-containing scaffold enhanced WJMSCs’ proliferation, alkaline phosphatase activity, and the osteogenic-related proteins of the scaffold. Under the synergistic effect of the static magnetic field, the CS scaffold containing Fe3O4 can not only enhance cell activity but also stimulate the simultaneous secretion of collagen I and osteocalcin. Overall, our results demonstrated that Fe3O4-containing CS/PCL scaffolds could be fabricated three dimensionally and combined with a static magnetic field to affect cell behaviors, potentially increasing the likelihood of clinical applications for bone tissue engineering.

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“…The concentration of IONPs is the key factor on cell viability when incubated with cells. Low iron concentration (50 and 100 mg/ml IONPs) had no obvious toxic effect on the proliferation of rADSCs, whereas the cell proliferation ability decreased at 200 mg/ml [ 70 ].…”

Section: Biocompatibilitymentioning

confidence: 99%

Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications

Song,

Wang,

Shi

et al. 2023

Regenerative Biomaterials

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In recent decades, bone tissue engineering, which is supported by scaffold, seed cells and bioactive molecules (BMs), has provided new hope and direction for treating bone defects. In terms of seed cells, compared to bone marrow mesenchymal stem cells, which were widely utilized in previous years, adipose-derived stem cells (ADSCs) are becoming increasingly favored by researchers due to their abundant sources, easy availability and multi-differentiation potentials. However, there is no systematic theoretical basis for selecting appropriate biomaterials loaded with ADSCs. In this review, the regulatory effects of various biomaterials on the behavior of ADSCs are summarized from four perspectives, including biocompatibility, inflammation regulation, angiogenesis and osteogenesis, to illustrate the potential of combining various materials with ADSCs for the treatment of bone defects. In addition, we conclude the influence of additional application of various BMs on the bone repair effect of ADSCs, in order to provide more evidences and support for the selection or preparation of suitable biomaterials and BMs to work with ADSCs. More importantly, the associated clinical case reports and experiments are generalized to provide additional ideas for the clinical transformation and application of bone tissue engineering loaded with ADSCs.

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Superparamagnetic core–shell electrospun scaffolds with sustained release of IONPs facilitating in vitro and in vivo bone regeneration

Abstract: Core–shell electrospun scaffolds with γ-Fe2O3 encapsulation were first fabricated with enhanced physical and mechanical properties, and could promote osteogenic differentiation of rADSCs and in vivo bone regeneration.

Cited by 8 publications

References 64 publications

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

Role of Iron Oxide (Fe2O3) Nanocomposites in Advanced Biomedical Applications: A State-of-the-Art Review

Synergistic Effect of Static Magnetic Fields and 3D-Printed Iron-Oxide-Nanoparticle-Containing Calcium Silicate/Poly-ε-Caprolactone Scaffolds for Bone Tissue Engineering

Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications

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