Superoxidised water: A promising disinfectant against bacterial and fungal pathogens

Gupta, Mukul; Prakash, Pradyot; Bharti, Shreekant; Paswan, Anil Kumar; Singh, Dinesh Kumar; Tilak, Ragini

doi:10.21276/apalm.2017.982

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Superoxidised water (SOW) is a newer disinfectant which has the ability to kill the microbes within the seconds of exposure. In previous studies, its efficacy has been assessed against the different bacterial and fungal pathogens including yeast and filamentous fungi 9 . In this present study, we assessed the efficacy of the freshly generated SOW against the Trichophyton spp.…”

Section: Discussionmentioning

confidence: 99%

“…It also impairs the solute transport as well as the salt balance, resulting in the cell lysis 8 . Potent disinfectant role of superoxidised water against bacteria and molds has been reported by different authors but, Best of our knowledge, no in vitro study has been conducted against the dermatophytes [9][10][11] . Against this background, we assessed the in-vitro activity of superoxidised water (SOW) against the dermatophytes isolated from skin lesions.…”

Section: Introductionmentioning

confidence: 99%

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Possible Role of Superoxidised Water in the Treatment of Trichophyton Infections: An In vitro Study

Gupta¹,

Sinha²,

Pandey³

et al. 2019

J Pure Appl Microbiol

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Superficial fungal infections are the common health seeking problem. These fungal infections are caused by three genera of Dermatophytes, naming Trichophyton, Microsporum, Epidermophyton. Among these three, Trichophyton spp. causes most of these lesions. Trichophyton spp. primarily infect the moist areas of human bodies. Different groups of antifungal agents are used in the treatment of these fungal infections. Despite availability of antifungal treatment, an increasing number of recurrent superficial fungal infections have been reported. We assessed the antidermatophytic activity of superoxidised water; a newer disinfectant, against Trichophyton spp. isolated from the cutaneous fungal infections. A total of 79 isolates of Trichophyton species including mentagrophytes (n=43) and rubrum (n=32) were exposed to freshly generated superoxidised water. A 50µl of 0.1 OD of the Trichophyton conidia were exposed to 500 µl of undiluted, 5 & 10 times diluted superoxidised water for one minute. A 10µl of these exposed conidia were inoculated on sDA. A 10µl of conidia (no exposure to superoxidised water) was also inoculated on sDA tube. tubes were incubated at 28°C in BOD incubator. No growth was observed in tubes having exposed conidia only to undiluted Superoxidised water, even after the 28 days of continuous incubation at 28°C. Growth within 7days was observed in the tubes having unexposed conidia and exposed to dilute superoxidised water. Undiluted superoxidised water showed the In vitro inhibition on Trichophyton mentagrophytes and Trichophyton rubrum which might be useful in future in the treatment of these infections.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Possible Role of Superoxidised Water in the Treatment of Trichophyton Infections: An In vitro Study

Gupta¹,

Sinha²,

Pandey³

et al. 2019

J Pure Appl Microbiol

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“…They may also be referred to as super-oxidised water, or most commonly by product names. § Bench research reports that SOSs have antibacterial [1][2][3]6,7 , antiviral 5 and antifungal 1 qualities against strains commonly observed in chronic wounds, including antibiotic-resistant bacteria 2 and biofilm based organisms 20,21 . There is laboratory-based evidence that they reduce inflammatory markers 4 (Level 5).…”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Evidence Summary: Super-oxidised solutions for chronic wounds

Haesler¹

2020

WPR

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Super-oxidised solutions are a low cost topical antiseptic option for chronic wounds. Antibacterial, antimicrobial and anti-fungal properties of SOSs have been established in laboratory research [1][2][3][4][5][6][7]. Level 1 evidence from a systematic review 8 and a randomised controlled trial (RCT) 9 showed SOS was as effective as povidone iodine in reduction microbial bioburden. Level 1 evidence from a systematic review 8 and four RCTs 9-12 showed SOS was superior to both povidone iodine 8,9,12 and saline 9-11 for promoting healing, established using different outcome measures (e.g. percent of wounds healed, 9 mean reduction in wound surface area, 12 rate of healing 9 and increase in granulation tissue). 10 This evidence, together with additional Level 2 13 and Level 4 [14][15][16] evidence, supported a Grade B recommendation (a weak recommendation) 17 . CLINICAL PRACTICE RECOMMENDATIONSAll recommendations should be applied with consideration to the wound, the patient, the health professional and the clinical context. Super-oxidised solutions could be used to reduce local infection and promote healing in chronic wounds, particularly diabetic foot ulcers (Grade B). SOURCES OF EVIDENCEThis summary was conducted using methods published by the Joanna Briggs Institute [17][18][19] . The summary is based on a literature search combining search terms related to SOSs and wounds. Only studies that used a solution described as super-oxidised on a chronic wound were included in the clinical evidence summary. Searches were conducted in CINAHL, Medline, the Cochrane Library and Google Scholar for evidence published up to December 2019 in English. Levels of evidence for intervention studies are reported in the table below.These awards are designed to encourage and reward those who publish their wound care clinical experience. The awards acknowledge excellence of original manuscripts, case presentations and clinical research undertaken within Australasia, both novice and advanced.

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“…Moreover, the inoculation of electrolyzed water was able to inhibit periodontopathogens such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, and Treponema denticola[22,29,32,35, 38,41,42,45,49,50,54, 56], by signi cantly reducing the percentage of viable bacteria or their CFU number after treatment. In addition, pathogens commonly found on infected canals, such as E. faecalis and Porphyromonas endodontalis, were also sensitive to electrolyzed water, showing signi cantly reduced CFU numbers and viability in a time-dependent manner[29,31,37,39,43,52,55]. Apart from that, electrolyzed water also showed antifungal activity by inhibiting the growth and diminishing the mean CFU counts of Candida albicans cultures in nine studies[29, 31, 34-36, 47, 52, 59, 60] (Table3).…”

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confidence: 99%

Electrolyzed water for the microbiologic control in the pandemic dental setting: A systematic review

Cárdenas

Campos

Francesco³

et al. 2022

Preprint

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Background The use of electrolyzed water has brought recent attention due to its antimicrobial properties. Indeed, electrolyzed water has been proposed for the sterilization of dental materials and instruments without compromising their structural integrity. In addition, electrolyzed water has been proposed as a mouthwash to control bacterial and viral oral infections without detrimental effects on the oral mucosa. However, there is no current consensus or evidence synthesis that could indicate its potentially favorable use in the dental setting, particularly nowadays during the COVID-19 context. Therefore, this systematic review aimed to elucidate whether the use of electrolyzed water could improve the microbiologic control in the COVID-19 pandemic dental setting. Methods MEDLINE via Pubmed, EMBASE, Cochrane’s CENTRAL, Scopus, LILACS, and Web of Science databases were searched up to September 2021 to identify experimental studies utilizing electrolyzed water for eliminating microorganisms in a dental setting. Besides, a manual and a grey literature search were performed. The data selection and extraction were performed individually and in duplicate. The Risk of Bias (RoB) was assessed with the Nature Publication Quality Improvement Project (NPQIP) score sheet. The study protocol was registered at PROSPERO CRD42020206986. Results From a total of 299 articles, 63 studies met the inclusion criteria. The included studies assessed several types of electrolyzed waters, which showed a high disinfection potential when used to deal with different oral conditions. Electrolyzed water demonstrated a broad antimicrobial spectrum and was highly efficient in the dental office disinfection against viruses, fungi, and bacteria, being compatible with most dental materials. In addition, the use of electrolyzed water could be protective against SARS-CoV-2 infection and contamination in the dental office. Regarding the RoB, only 35.18% of entries were answered as ‘Yes’, thus achieving less than half of the reporting sheet. Conclusion Electrolyzed water is effective in disinfecting contaminated surfaces, dental materials, and equipment. Therefore, their use is recommendable in the SARS-CoV-2 pandemic dental setting.

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Superoxidised water: A promising disinfectant against bacterial and fungal pathogens

Cited by 5 publications

References 13 publications

Possible Role of Superoxidised Water in the Treatment of Trichophyton Infections: An In vitro Study

Possible Role of Superoxidised Water in the Treatment of Trichophyton Infections: An In vitro Study

Evidence Summary: Super-oxidised solutions for chronic wounds

Electrolyzed water for the microbiologic control in the pandemic dental setting: A systematic review

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