Superoxide production during refeeding in patients with anorexia nervosa

Vaisman, Nachum; Tabachnik, Elvan; Hahn, Talia; Voet, Hillary; Guy, Nina

doi:10.1016/0026-0495(92)90292-i

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…When examining the medication that the patients received during the study period, no consistent pattern was found which could associate medication with PMN functional capacity. The effect of diseases on PMN function is not clear, since highly variable results are reported when examining in vitro PMN function in various disorders [26–29]. Our finding of a negative correlation between superoxide generation and the acute‐phase reactant serum orosomucoid suggests that neutrophil ·O 2 – production might be adversely affected by factors associated with inflammatory activity.…”

Section: Discussionmentioning

confidence: 78%

Impaired granulocyte formylpeptide‐induced superoxide generation in chronically ill, malnourished, elderly patients

Cederholm

Gyllenhammar

1999

Journal of Internal Medicine

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Abstract. Cederholm T, Gyllenhammar H (Huddinge University Hospital, Huddinge, Sweden). Impaired granulocyte formylpeptide-induced superoxide generation in chronically ill, malnourished, elderly patients. J Intern Med 1999; 245: 475]482.Objective. Protein-energy malnutrition (PEM), often occurring in patients with chronic disease, is associated with a decreased capacity to combat infections. In this study we assessed polymorphonuclear neutrophil (PMN) superoxide anion (?O 2 2 ) formation in elderly PEM patients with various chronic diseases. Design and subjects. Nineteen patients (75 6 1 years), with body mass index 17.1 6 0.4, and 19 age-matched healthy controls were included. Fourteen patients and 14 controls were re-examined in a 3 month follow-up. Setting. A service of internal medicine at a university-affiliated hospital. Interventions. Eight patients were prescribed a dietary liquid supplementation during the observation period.Main outcome measures. Superoxide production in PMN induced by fMLP (a receptor ligand) and phorbol myristate acetate (PMA), which acts directly on protein kinase C. Results. fMLP-induced superoxide generation in the malnourished patients was 55 6 5% of that of the controls. However, the patients retained their capacity, 108 6 6% of control PMN generation, to respond to PMA. In those who received formula supplementation, fMLP-generated ?O 2 2 production levels were 48 6 8 and 73 6 13% (P = 0.12) of those of controls at the start and after 3 months, respectively. Corresponding figures in those who were not prescribed supplementation were 57 6 8 and 64 6 4% (P = 0.55). Conclusion. Possibly contributing to reduced host defence, receptor ligand-induced PMN generation of ?O 2 2 is significantly lower in chronically ill, elderly patients with PEM than in age-matched healthy controls.

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Section: Discussionmentioning

confidence: 78%

Impaired granulocyte formylpeptide‐induced superoxide generation in chronically ill, malnourished, elderly patients

Cederholm

Gyllenhammar

1999

Journal of Internal Medicine

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“…56 One study has shown an initial decline in neutrophil superoxide anion activity during refeeding in AN patients, suggesting a possible mechanism for increased susceptibility to infection. 57 In our case series two patients developed occult sepsis, one of whom developed Clostridium difficile diarrhoea and one who developed a severe lower respiratory tract infection requiring treatment on the High Dependency Unit. One episode of occult sepsis was fatal despite inotropic support in an Intensive Care Unit setting.…”

Section: Infectionmentioning

confidence: 70%

Complications of Emergency Refeeding in Anorexia Nervosa: Case series and review

Webb

Smith²,

Thursby‐Pelham³

et al. 2011

Acute Med

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The refeeding syndrome is common among patients with anorexia nervosa. It may be lethal and has many manifestations. We report a case series of 14 anorexic patients admitted for feeding to a single British centre. There was a high prevalence of the refeeding syndrome, with three cases requiring higher dependency unit support and one death. We present a review of the refeeding syndrome in anorectics and highlight our impression that infection among such patients may be serious and under-recognised.

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“…Here, the refeeding syndrome is a serious complication of anorexia treatment that results from excessive nutrient supplementation resulting in rapid hormonal and metabolic disturbances and high morbidity and mortality ( 170 , 231 ). In fact, diminished ROS production during the initial period of refeeding (11-40 days of hospitalization) in patients with anorexia that return to normal values to that of healthy control subjects with an extended period of refeeding is commonly seen ( 232 ). A fiber-rich diet in this refeeding regime may be sufficient to restore efficient immunity ( 233 ).…”

Section: Regulation Of Neutrophil Functions In Various Nutrient Envir...mentioning

confidence: 99%

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

Thind,

Uhlig,

Glogauer

et al. 2024

Front. Immunol.

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Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to engage a wide range of metabolic pathways for biosynthesis and bioenergetics for mediating biological processes such as development in the bone marrow and antimicrobial activity such as ROS production and NET formation, inflammation and tissue repair. We first discuss recent work on neutrophil development and functions and the metabolic processes to regulate granulopoiesis, neutrophil migration and trafficking as well as effector functions. We then discuss metabolic syndromes with impaired neutrophil functions that are influenced by genetic and environmental factors of nutrient availability and usage. Here, we particularly focus on the role of specific macronutrients, such as glucose, fatty acids, and protein, as well as micronutrients such as vitamin B3, in regulating neutrophil biology and how this regulation impacts host health. A special section of this review primarily discusses that the ways nutrient deficiencies could impact neutrophil biology and increase infection susceptibility. We emphasize biochemical approaches to explore neutrophil metabolism in relation to development and functions. Lastly, we discuss opportunities and challenges to neutrophil-centered therapeutic approaches in immune-driven diseases and highlight unanswered questions to guide future discoveries.

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Superoxide production during refeeding in patients with anorexia nervosa

Cited by 5 publications

References 9 publications

Impaired granulocyte formylpeptide‐induced superoxide generation in chronically ill, malnourished, elderly patients

Impaired granulocyte formylpeptide‐induced superoxide generation in chronically ill, malnourished, elderly patients

Complications of Emergency Refeeding in Anorexia Nervosa: Case series and review

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

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