Superoxide dismutase (SOD), advanced oxidation protein products (AOPP), and disease-modifying treatment are related to better relapse recovery after corticosteroid treatment in multiple sclerosis

Obradović, Dragana; Andjelic, Tamara; Ninković, Milica; Dejanović, Bratislav; Kotur‐Stevuljević, Jelena

doi:10.1007/s10072-020-04928-y

Cited by 15 publications

(23 citation statements)

References 37 publications

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“…We found that the concentration of AOPP was about twofold higher in the RRMS patients than in controls, which is consistent with the study conducted by Obradovic et al [ 20 ].…”

Section: Discussionsupporting

confidence: 93%

“…The determination of AOPP concentration was successfully used to confirm in vitro inflammatory status and dysregulated immune responses [ 34 ]. In the study by Obradovic et al [ 20 ], the decrease in the concentration of AOPP was shown to be a good prognostic parameter for clinical outcomes in MS patients, including recovery after treatment of relapse [ 20 ]. A similar conclusion was made in the meta-analysis conducted by Rodrigues et al [ 35 ], who claimed that AOPP may represent a new target for drug development in MS treatment and a possible biomarker to monitor the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Considering individual differences in MS course and response to treatment, there is an ongoing search for reliable biomarkers of MS activity and progression. Parameters of oxidative stress certainly deserve attention in this field, and thus they have already been investigated in MS patients [ 19 , 20 ]. One of these parameters is the concentration of advanced oxidation protein products (AOPP), a relevant factor in the pathogenesis of many diseases [ 21 ], including immune-mediated and inflammatory ones [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Parameters of oxidative stress certainly deserve attention in this field, and thus they have already been investigated in MS patients [ 19 , 20 ]. One of these parameters is the concentration of advanced oxidation protein products (AOPP), a relevant factor in the pathogenesis of many diseases [ 21 ], including immune-mediated and inflammatory ones [ 20 ]. AOPP seem associated, i.a., with dendritic cell activation and play a crucial role in neuroinflammation and oxidation processes in neurodegenerative diseases [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Selected Oxidant/Antioxidant Parameters in Patients with Relapsing-Remitting Multiple Sclerosis Undergoing Disease-Modifying Therapies

Bizoń

Chojdak-Łukasiewicz²,

Kołtuniuk³

et al. 2022

Antioxidants

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The aim of this study was to evaluate oxidative stress parameters, specifically the concentration of advanced oxidation protein products (AOPP) and ferric-reducing antioxidant power (FRAP), in the serum of patients with relapsing-remitting multiple sclerosis (RRMS). We also analyzed the relationships between each parameter and selected clinical/laboratory multiple-sclerosis-related parameters. The study group comprised 204 patients with RRMS and 29 healthy, age-matched controls. The concentration of AOPP was significantly higher in the RRMS patients than in controls. ROC analysis showed the ability of AOPP to distinguish between the patients with RRMS and controls (the value of AUC was 94.8%, with a sensitivity of 89.69% and specificity of 89.3%). AOPP and FRAP were significantly higher in male than in female RRMS patients. Correlations were found between AOPP and the laboratory markers of inflammation. AOPP differed in the subgroups of patients treated with particular medications. Our findings indicate an increase in the markers of oxidative stress in the serum of RRMS patients, possibly linked with chronic inflammation. Gender and type of treatment affected the markers of oxidative stress.

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“…We found that the concentration of AOPP was about twofold higher in the RRMS patients than in controls, which is consistent with the study conducted by Obradovic et al [ 20 ].…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Selected Oxidant/Antioxidant Parameters in Patients with Relapsing-Remitting Multiple Sclerosis Undergoing Disease-Modifying Therapies

Bizoń

Chojdak-Łukasiewicz²,

Kołtuniuk³

et al. 2022

Antioxidants

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“…In the past years, nitrosative stress species have gained increasing scientific attention due to their potential prognostic and diagnostic value. However, the use of nitrosative stress markers in the diagnostic workup for MS is hampered by heterogeneous and, at times, even contradictory results from previous studies [ 39 , 40 ], which is why we conducted this meta-analysis. Comparing MS and NIOND, we observed an overall effect for nitrosative stress species in the CSF but not in the serum.…”

Section: Discussionmentioning

confidence: 99%

Nitrosative Stress Molecules in Multiple Sclerosis: A Meta-Analysis

et al. 2021

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Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system of unknown etiology. As it is still a diagnosis of exclusion, there is an urgent need for biomarkers supporting its diagnosis. Increasing evidence suggests that nitrosative stress may play a pivotal role in the pathogenesis of MS. However, previous reports supporting the role of nitrosative stress molecules as disease biomarkers are inconsistent overall. We therefore systematically analyzed the existing literature to compare the serum and cerebrospinal fluid (CSF) levels of nitrite/nitrate in MS patients with those in patients with noninflammatory other neurological diseases (NIOND) and healthy controls (HC), respectively. We searched the PubMed database and included original articles investigating nitrite/nitrate levels in MS patients and NIOND patients or HC based on predefined selection criteria. Effect sizes were estimated by the standardized mean difference using a random effects model. Our results suggest that MS is associated with higher nitrite/nitrate levels within the CSF compared with patients with NIOND (SMD of 1.51; 95% CI: 0.72, 2.30; p = 0.0008). Likewise, nitrite/nitrate in the CSF of MS patients trends towards increased levels compared with those of HC but does not reach statistical significance (SMD of 3.35; 95% CI: −0.48, 7.19; p = 0.07). Measurement of nitrite/nitrate in the CSF might be a valuable tool facilitating the differentiation of MS and NIOND. Further studies with more homogeneous study criteria are needed to corroborate this hypothesis.

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Histomorphological and Biochemical Analysis of Rat Model of Menopausal Skin Aging

Yang

Hao

et al. 2022

Bull Exp Biol Med

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Superoxide dismutase (SOD), advanced oxidation protein products (AOPP), and disease-modifying treatment are related to better relapse recovery after corticosteroid treatment in multiple sclerosis

Cited by 15 publications

References 37 publications

Evaluation of Selected Oxidant/Antioxidant Parameters in Patients with Relapsing-Remitting Multiple Sclerosis Undergoing Disease-Modifying Therapies

Evaluation of Selected Oxidant/Antioxidant Parameters in Patients with Relapsing-Remitting Multiple Sclerosis Undergoing Disease-Modifying Therapies

Nitrosative Stress Molecules in Multiple Sclerosis: A Meta-Analysis

Histomorphological and Biochemical Analysis of Rat Model of Menopausal Skin Aging

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