Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Zelko, Igor N.; Mariani, Thomas J.; Folz, Rodney J.

doi:10.1016/s0891-5849(02)00905-x

Cited by 1,787 publications

(1,285 citation statements)

References 144 publications

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“…Since the highest level of GSTA expression was in steroidogenically active cells it has been proposed, that the role of GSTA may be linked to oxygen stress induced by ROS generated during steroidogenesis. Superoxide dismutases (SOD ) are a group of enzymes that reduce superoxide anion to hydrogen peroxide and molecular oxygen [45]. In our study, GPX3 , GSTA1, GSTA2, GSTA3 and SOD2 showed increased expression in MNIVF cycles and thus, suggesting higher exposure of the developing follicle to ROS than in COH cycles.…”

Section: Discussionmentioning

confidence: 55%

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Papler

Bokal

Tacer

et al. 2013

J Assist Reprod Genet

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Purpose The aim of our study was to determine whether there are any differences in the cumulus cell gene expression profile of mature oocytes derived from modified natural IVF and controlled ovarian hyperstimulation cycles and if these changes could help us understand why modified natural IVF has lower success rates. Methods Cumulus cells surrounding mature oocytes that developed to morulae or blastocysts on day 5 after oocyte retrieval were submitted to microarray analysis. The obtained data were then validated using quantitative real-time PCR. Results There were 66 differentially expressed genes between cumulus cells of modified natural IVF and controlled ovarian hyperstimulation cycles. Gene ontology analysis revealed the oxidation-reduction process, glutathione metabolic process, xenobiotic metabolic process and gene expression were significantly enriched biological processes in MNIVF cycles.Among differentially expressed genes we observed a large group of small nucleolar RNA's whose role in folliculogenesis has not yet been established. Conclusion The increased expression of genes involved in the oxidation-reduction process probably points to hypoxic conditions in modified natural IVF cycles. This finding opens up new perspectives for the establishment of the potential role that oxidation-reduction processes have in determining success rates of modified natural IVF.

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Section: Discussionmentioning

confidence: 55%

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Papler

Bokal

Tacer

et al. 2013

J Assist Reprod Genet

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“…CuZnSOD is usually classified into two isoforms according to its localization. Extracellular CuZnSOD has an N-terminal signal cleavage peptide, whereas intracellular CuZnSOD has no signal peptide [30]. For MgeCuZnSOD, no signal peptide was found, indicating that it belongs to a member of the intracellular CuZnSOD family.…”

Section: Resultsmentioning

confidence: 98%

Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis

Wang

Yuan

et al. 2013

Fish & Shellfish Immunology

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“…SOD constitutes the primary defense against superoxide anion radicals by dismutating 2 molecules of the anion superoxide radical to hydrogen peroxide and molecular oxygen. It consists of 3 isoforms, cytosolic SOD1, mitochondrial SOD2, and extracellular SOD3 (29). HO-1 is also a redox-sensitive enzyme and has been considered a guardian against oxidative tissue injury in acute inflammation (30).…”

Section: Effects Of ␣-Msh On Murine Collagen Synthesis and Fibrosis 597mentioning

confidence: 99%

α‐melanocyte–stimulating hormone suppresses bleomycin‐induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?

Kokot¹,

Sindrilaru²,

Sunderkötter³

et al. 2009

Arthritis & Rheumatism

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HO-1). In the BLM mouse model, ␣-MSH reduced skin fibrosis and collagen content and increased tissue levels of SOD2 and HO-1. In skin and HDFs from patients with SSc, both MC-1R and POMC messenger RNAs were detected, but there were no differences compared with healthy controls.Conclusion. Alpha-melanocyte-stimulating hormone and related peptides that exert their effects via MC-1R may provide a novel antifibrogenic therapeutic tool for the treatment of fibrotic diseases such as scleroderma.Fibrotic diseases are a major challenge in medicine with regard to both pathogenesis and therapeutic intervention. The clinical spectrum of such disorders comprises many organs and includes localized and systemic scleroderma (SSc), idiopathic pulmonary fibrosis, Presented by Dr. Kokot in partial fulfillment of the requirements for a PhD degree,

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Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression

Cited by 1,787 publications

References 144 publications

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Molecular characterization of a manganese superoxide dismutase and copper/zinc superoxide dismutase from the mussel Mytilus galloprovincialis

α‐melanocyte–stimulating hormone suppresses bleomycin‐induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?

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