Superoxide Dismutase Activity in the Rat Exposed to Extreme Environmental Conditions

Petrović, Vesna; Spasić, M.; Milić, B.; Saičić, Zorica S.; Radojičić, R.

doi:10.1007/978-1-4615-8345-5_14

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Over a period of 21days, Cu,ZnSOD and MnSOD specific activities (activities per mg of protein) were higher than those in animals acclimated to 22°C (Davidovic et al, 1999). Conversely, over the same period total SOD activity (activity per mg of tissue) was higher than that in controls adapted to 30°C, whereas specific activity was unchanged in comparison with controls because of the increase in tissue protein content (Petrovic et al, 1987). These data were subsequently confirmed by Barja de Quiroga and colleagues (Barja de Quiroga et al, 1991), who found that, in rats acclimated to 6°C for 21days, SOD activity per mg of tissue reached around 400% of the values of controls acclimated at 28°C, and protein concentration was around three times higher in cold-acclimated rats than in controls.…”

Section: Cold Exposurementioning

confidence: 81%

Oxidative stress in cold-induced hyperthyroid state

Venditti

Stefano

Meo

2010

Journal of Experimental Biology

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SUMMARYExposure of homeothermic animals to low environmental temperature is associated with oxidative stress in several body tissues. Because cold exposure induces a condition of functional hyperthyroidism, the observation that tissue oxidative stress also happens in experimental hyperthyroidism, induced by 3,5,3Ј-triiodothyronine (T 3 ) treatment, suggests that this hormone is responsible for the oxidative damage found in tissues from cold-exposed animals. Examination of T 3 -responsive tissues, such as brown adipose tissue (BAT) and liver, shows that changes in factors favoring oxidative modifications are similar in experimental and functional hyperthyroidism. However, differences are also apparent, likely due to the action of physiological regulators, such as noradrenaline and thyroxine, whose levels are different in cold-exposed and T 3 -treated animals. To date, there is evidence that biochemical changes underlying the thermogenic response to cold as well as those leading to oxidative stress require a synergism between T 3 -and noradrenaline-generated signals. Conversely, available results suggest that thyroxine (T 4 ) supplies a direct contribution to cold-induced BAT oxidative damage, but contributes to the liver response only as a T 3 precursor.

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Section: Cold Exposurementioning

confidence: 81%

Oxidative stress in cold-induced hyperthyroid state

Venditti

Stefano

Meo

2010

Journal of Experimental Biology

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Ivan Djaja (Jean Giaja) and the Belgrade School of Physiology

Anđjus

Stojilković²,

Cvijic̀³

2011

Physiol Res

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The founder of physiology studies in the Balkans and the pioneer of research on hypothermia, Ivan Djaja (Jean Giaja) was born 1884 in L’Havre. Giaja gained his PhD at the Sorbonne in 1909. In 1910 he established the first Chair of Physiology in the Balkans and organized the first Serbian Institute for Physiology at the School of Philosophy of the University of Belgrade. He led this Institute for more than 40 subsequent years. His most notable papers were in the field of thermoregulation and bioenergetics. Djaja became member of the Serbian and Croatian academies of science and doctor honoris causa of Sorbonne. In 1952 for the seminal work on the behavior of deep cooled warm blooded animals he became associate member of the National Medical Academy in Paris. In 1955 the French Academy of Sciences elected him as associate member in place of deceased Sir Alexander Fleming. Djaja died in 1957 during a congress held in his honor. He left more than 200 scientific and other papers and the golden DaVincian credo “Nulla dies sine experimento”. His legacy was continued by several generations of researchers, the most prominent among them being Stefan Gelineo, Radoslav Andjus and Vojislav Petrović.

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Superoxide Dismutase Activity in the Rat Exposed to Extreme Environmental Conditions

Cited by 2 publications

References 26 publications

Oxidative stress in cold-induced hyperthyroid state

Oxidative stress in cold-induced hyperthyroid state

Ivan Djaja (Jean Giaja) and the Belgrade School of Physiology

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