Superoxide dismutase activity in gingiva in type-2 diabetes mellitus patients with chronic periodontitis

Akalın, Ferda Alev; Işıksal, Eda; Baltacıoğlu, Esra; Renda, Nurten; Karabulut, Erdem

doi:10.1016/j.archoralbio.2007.07.009

Cited by 42 publications

(39 citation statements)

References 62 publications

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“…The mean total salivary antioxidant capacity of the present cohort at baseline was 2083 U.Carr which resulted higher than normal range thus denoting a potential state of inflammation in diabetic patients affected by moderate periodontitis. The over-production of free radicals caused by periodontal inflammation is in fact supposed to cause an up-regulation of the anti-oxidant defence [25,26]. The results of the present study agree with literature relating high levels of salivary antioxidants (SAT) to a possible periodontal inflammatory condition.…”

Section: Number Of Dm-2 38supporting

confidence: 82%

Oxidative stress and periodontal disease in diabetic patients: a 3-month pilot study

Marconcini¹,

Gianmarinaro²,

Giampietro³

et al. 2017

Dent Oral Craniofac Res

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Aim: Oxidative stress is involved in both Periodontal Disease (PD) and Diabetes Mellitus (DM). The present study aimed to evaluate the oxidative balance in diabetic patients diagnosed with PD before and after non-surgical periodontal treatment. Materials and methods:Sixty patients were divided into three groups all receiving non-surgical periodontal treatment plus either chlorhexidine, ozone-therapy or antioxidant mouth-rinse. Probing depth (PPD), Percentage Plaque Index (%PI) and Percentage Bleeding on Probing (%BoP) were recorded. Free-radicals (dROMs), plasmatic antioxidants (PAT), salivary antioxidants (SAT) and glycated hemoglobin ( HbA 1 c) were measured. Results: Mean PPD at baseline was 3.14 mm. Mean PPD three months after was 2.05 mm. The overall %PI at baseline was 55% and %BOP 76%. Three months after treatment %PI was 34% and %BoP was 64%. The longitudinal analysis did not show differences between groups. Mean dROMs at baseline was 353 U. Carr (oxidative stress) and decreased after three months reaching 295 U. Carr (normal). SAT was 2083 U. Carr at baseline (inflammation) and decreased to 1337 U. Carr (ideal). The longitudinal analysis did not show differences between groups. Mean HbA 1 c at baseline was 6.92% and decreased significantly to 6.63% three months after treatment. Conclusion:Based on the results of the present study, oxidative stress should be further investigated as a potential modulator of the clinical course of both DM and PD.

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Section: Number Of Dm-2 38supporting

confidence: 82%

Oxidative stress and periodontal disease in diabetic patients: a 3-month pilot study

Marconcini¹,

Gianmarinaro²,

Giampietro³

et al. 2017

Dent Oral Craniofac Res

View full text Add to dashboard Cite

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“…Akalin et al 46 also found that gingival SOD activity was lower in periodontitis groups than the matched control groups and type 2 diabetes mellitus patients with healthy periodontal ligament had the highest but the CP group had the lowest SOD levels. However, consistent with our finding, other studies 41,47 have shown that SOD activity increases with the progression of inflammation in CP patients.…”

Section: Discussionmentioning

confidence: 97%

Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy

et al. 2010

Australian Dental Journal

218

217

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Background: Recent data have demonstrated increased lipid peroxidation (LPO) levels and oxidative stress in periodontitis. Malondialdehyde (MDA) and superoxide dismutase (SOD) are both increased during oxidative stress. Furthermore, this study examined SOD concentration, total oxidative status (TOS) and MDA levels in periodontal patients and investigated the longitudinal effect of periodontal therapy on the index levels of chronic periodontitis (CP) patients. Methods: Serum, saliva and gingival crevicular fluid (GCF) samples were obtained from 48 CP patients and 35 healthy control subjects prior to, as well as after 16 weeks following non-surgical post-periodontal therapy. MDA, TOS and SOD and clinical parameters were determined pre-and post-therapy. Results: The levels of TOS and SOD values were significantly higher in the CP group than in the control group (p < 0.05), but only MDA in GCF. Post-periodontal therapy, serum, saliva and GCF TOS and SOD levels significantly decreased compared to basal levels (p < 0.05), but only MDA in GCF. Conclusions: LPO was higher in the periodontal region, with TOS and SOD increasing both locally and peripherally. Nonsurgical therapy can restore and control the subject antioxidant capacity by locally and systemically modifying the levels of MDA, TOS and SOD.

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“…While Panjamurthy et al (52) reported significantly higher SOD levels in periodontitis compared to controls, Akalın et al (54,55) reported lower SOD in periodontitis patients. In our study, the decreases in SOD levels in rats affected by periodontitis were not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

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The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties.Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.

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Superoxide dismutase activity in gingiva in type-2 diabetes mellitus patients with chronic periodontitis

Cited by 42 publications

References 62 publications

Oxidative stress and periodontal disease in diabetic patients: a 3-month pilot study

Oxidative stress and periodontal disease in diabetic patients: a 3-month pilot study

Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

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