Superoxidase dismutase (SOD) topical use in oncologic patients: treatment of acute cutaneous toxicity secondary to radiotherapy

García, Álvaro Manzanas; Carrizosa, María Concepción López; Ocaña, C. Vallejo; Ots, P. Samper; Pérez, Jesús; Accame, Emilia Carretero; Gómez-Serranillos, M. Pilar; Valle, Luis Del

doi:10.1007/s12094-008-0174-0

Cited by 21 publications

(21 citation statements)

References 12 publications

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“…Thirty-three of those trials were aimed at preventing radiation-induced skin reactions 2,3, , and six trials evaluated management regimens for existing skin reactions [47][48][49][50][51][52] . The agents evaluated in the trials varied greatly.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-one of the trials were open 3,16,19,20,24-26, 28,29,32-35,37-43,45 , three were single-blind 17,22,27 , and nine were double-blind 2,18,21,23,30,31,36,44,46 . Of the six management trials, three were rcts 49,50,52 , and three were nonrandomized clinical trials 47,48,51 . One of the trials was double-blind 52 ; the remaining trials were open [47][48][49]51,52 .…”

Section: Resultsmentioning

confidence: 99%

“…Of the six management trials, three were rcts 49,50,52 , and three were nonrandomized clinical trials 47,48,51 . One of the trials was double-blind 52 ; the remaining trials were open [47][48][49]51,52 .…”

Section: Resultsmentioning

confidence: 99%

“…Skin reactions were often assessed by one evaluator, which was commonly a radiation oncologist, dermatologist, research nurse, research assistant, radiation therapist, principal investigator, or other medical professional 3,17,20,21,24,26,27,32,33,35,39,44,46,50 . A few studies incorporated an inter-rater reliability measure by having more than one evaluator assess the skin reactions 23,34,36,45,49,51 ; the remaining studies did not describe who assessed the radiated area or areas 2,16,19,25,28,30,31,38,[41][42][43]47,48 .…”

Section: Resultsmentioning

confidence: 99%

“…Garcia et al 48 conducted a phase i trial evaluating the efficacy of superoxide dismutase (sod) to treat grade 2 dermatitis (rtog) in varying cancer types. Those authors demonstrated a 77.1% response at the completion of radiation treatment (17.5% complete response; 59.6% partial response) and no worsening of the condition at the end of the 12-week study period.…”

Section: Nonsteroidal Topical Creammentioning

confidence: 99%

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Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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Radiation therapy is a common treatment for cancer patients. One of the most common side effects of radiation is acute skin reaction (radiation dermatitis) that ranges from a mild rash to severe ulceration. Approximately 85% of patients treated with radiation therapy will experience a moderate-to-severe skin reaction. Acute radiation-induced skin reactions often lead to itching and pain, delays in treatment, and diminished aesthetic appearance-and subsequently to a decrease in quality of life.Surveys have demonstrated that a wide variety of topical, oral, and intravenous agents are used to prevent or to treat radiation-induced skin reactions. We conducted a literature review to identify trials that investigated products for the prophylaxis and management of acute radiation dermatitis. Thirty-nine studies met the pre-defined criteria, with thirty-three being categorized as prophylactic trials and six as management trials.For objective evaluation of skin reactions, the Radiation Therapy Oncology Group criteria and the U.S. National Cancer Institute Common Toxicity Criteria were the most commonly used tools (65% of the studies). Topical corticosteroid agents were found to significantly reduce the severity of skin reactions; however, the trials of corticosteroids evaluated various agents, and no clear indication about a preferred corticosteroid has emerged. Amifostine and oral enzymes were somewhat effective in preventing radiation-induced skin reactions in phase ii and phase iii trials respectively; further large randomized controlled trials should be undertaken to better investigate those products. Biafine cream (Ortho-McNeil Pharmaceuticals, Titusville, NJ, U.S.A.) was found not to be superior to standard regimes in the prevention of radiation-induced skin reactions (n = 6).In conclusion, the evidence is insufficient to support the use of a particular agent for the prevention and management of acute radiation-induced skin reactions. Future trials should focus on comparing agents and approaches that, in phase i and ii trials, suggest efficacy. These future phase iii randomized controlled trials must clearly distinguish between preventive and management strategies for radiation-induced dermatitis. Only then can evidence-based guidelines be developed, with the hope of standardizing the approach across centres and of improving the prevention and management of radiation-induced dermatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Nonsteroidal Topical Creammentioning

confidence: 99%

See 3 more Smart Citations

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

et al. 2010

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Eco‐Friendly and Scalable Synthesis of Fullerenols with High Free Radical Scavenging Ability for Skin Radioprotection

Zhao

Wang

Xie

et al. 2021

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Radiation dermatitis is a common but torturous side effect during radiotherapy, which greatly decreases the life quality of patients and potentially results in detrimental cessation of tumor treatment. Fullerenol, known as “free radical sponge,” is a great choice for skin radioprotection because of its broad‐spectrum free radical scavenging performance, good chemical stability, and biosafety. In this work, a facile scalable and eco‐friendly synthetic method of fullerenols by catalyst assistant mechanical chemistry strategy is provided. As no organic solvent or high concentration of acid and alkali is introduced to this synthetic system, large‐scale (>20 g) production of fullerenols with high yield (>95%) is obtained and no complicated purification is required. Then, the skin radioprotective performance of fullerenols is systematically explored for the first time. In vitro results indicate that fullerenols significantly block the reactive oxygen species‐induced damage and enhance the viability of irradiated human keratinocyte cells. In vivo experiments suggest that medical sodium hyaluronate hydrogels loaded with fullerenols are suitable for skin administration and powerfully mitigate radiodermatitis via effectively protecting epidermal stem cells. The work not only provides an efficient gram‐scale and eco‐friendly synthetic method of fullerenols, but also promotes the development of fullerenols as potential skin radioprotectors.

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Ascidian‐Inspired Temperature‐Switchable Hydrogels with Antioxidant Fullerenols for Protecting Radiation‐Induced Oral Mucositis and Maintaining the Homeostasis of Oral Microbiota

Zhao

Wang

et al. 2023

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A key characteristic of radiation‐induced oral mucositis (RIOM) is oxidative stress mediated by the “reactive oxygen species (ROS) storm” generated from water radiolysis, resulting in severe pathological lesions, accompanied by a disturbance of oral microbiota. Therefore, a sprayable in situ hydrogel loaded with “free radical sponge” fullerenols (FOH) is developed as antioxidant agent for RIOM radioprotection. Inspired by marine organisms, 3,4,5‐trihydroxyphenylalanine (TOPA) which is enriched in ascidians is grafted to clinically approved temperature‐switchable Pluronic F127 to produce gallic acid (containing the TOPA fragment)‐modified Pluronic F127 (MGA) hydrogels to resist the fast loss of FOH via biomimetic adhesion during oral movement and saliva erosion. Based on this, progressive RIOM found in mice is alleviated by treatment of FOH‐loaded MGA hydrogels whether pre‐irradiation prophylactic administration or post‐irradiation therapeutic administration, which contributes to maintaining the homeostasis of oral microbiota. Mechanistically, FOH inhibits cell apoptosis by scavenging radiation‐induced excess ROS and up‐regulates the inherent enzymatic antioxidants, thereby protecting the proliferation and migration of mucosal epithelial cells. In conclusion, this work not only provides proof‐of‐principle evidence for the oral radioprotection of FOH by blocking the “ROS storm”, but also provides an effective and easy‐to‐use hydrogel system for mucosal in situ administration.

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Superoxidase dismutase (SOD) topical use in oncologic patients: treatment of acute cutaneous toxicity secondary to radiotherapy

Abstract: The employment of SOD topically is efficient in the treatment of radiodermatitis, which is an acute side effect of radiotherapy.

Cited by 21 publications

References 12 publications

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Prophylaxis and Management of Acute Radiation-Induced Skin Reactions: A Systematic Review of the Literature

Eco‐Friendly and Scalable Synthesis of Fullerenols with High Free Radical Scavenging Ability for Skin Radioprotection

Ascidian‐Inspired Temperature‐Switchable Hydrogels with Antioxidant Fullerenols for Protecting Radiation‐Induced Oral Mucositis and Maintaining the Homeostasis of Oral Microbiota

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