Superovulation in the cow with a single intramuscular injection of FSH dissolved in polyvinylpyrrolidone

Yamamoto, Masao; Ooe, Masato; Kawaguchi, Mamoru; Suzuki, Takahiro

doi:10.1016/0093-691x(94)90184-k

Cited by 41 publications

(23 citation statements)

References 13 publications

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“…The use of a single injection of FSH diluted in various degradable agents such as propylene glycol (PG), polyvinylpyrrolidone, aluminum hydroxide gel or hyaluronan (HA) was previously tested in cattle and ewes (Lopez-Sebastian et al 1993;Dattena et al 1994;Yamamoto et al 1994;Takedomi et al 1995;D'Alessandro et al 2001;Kimura et al 2007;Tribulo et al 2012). Although these agents were effective at eliciting a slow release of FSH to induce a superovulatory response, in humans, PG and polyvinylpyrrolidone have caused allergic reactions (Catanzaro and Smith 1991;Gonzalo et al 1999;Yoshida et al 2007;Marques et al 2011), while aluminum hydroxide induced neuropathological reactions and macrophagic myofascitis (Gherardi et al 2001;Shaw and Petrik 2009).…”

Section: Discussionmentioning

confidence: 99%

“…To overcome these limitations, alternative delivery of FSH has been proposed. For example, a single superovulation injection with FSH in degradable polymers to sustain hormone release has been studied in ruminants (Lopez-Sebastian et al 1993;Yamamoto et al 1994;Satoh et al 1996;Sugano and Shinogi 1999;D'Alessandro et al 2001;Kimura et al 2007;Tribulo et al 2012). In cattle, administration of FSH dissolved in various substances, including polyvinylpyrrolidone, aluminum hydroxide gel https://doi.org/10.17221/52/2016-VETMED or hyaluronan (HA), increased ovarian responses compared to multiple FSH injections (Bo et al 1994;Yamamoto et al 1995;Kimura et al 2007;Tribulo et al 2012;Chasombat et al 2013).…”

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confidence: 99%

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A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

Panyaboriban¹,

Suwimonteerabutr²,

Swangchan-Uthai³

et al. 2018

Vet. Med. - Czech

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ABSTRACT:Superovulation is an important step in assisted reproductive technology. Due to its short half-life, follicle stimulating hormone is usually given twice daily to ewes for three to five days, which is both time-and labour-intensive. However, dissolving follicle stimulating hormone in degradable polymers to delay absorbtion has been effective in ruminants. Experiment 1 was performed to compare a split-single follicle stimulating hormone dissolved in hyaluronan (S group; 150 mg follicle stimulating hormone on the first day and 30 mg 48 h later; n = 21) and six decreasing doses of follicle stimulating hormone (M group; 50, 50, 30, 30, 10 and 10 mg; n = 22) at 12-h intervals. Ovarian responses and numbers of recovered ova/embryos did not differ significantly between groups. However, there tended to be more Grade 1 and 2 embryos in S vs M groups (mean ± SEM, 5.1 ± 4.9 vs 2.9 ± 2.9, respectively; P = 0.08). Experiment 2 tested the effectiveness of a simplified split-single follicle stimulating hormone in purebred sheep on a commercial farm. The numbers of recovered good-grade embryos (day 2) were 4.8 ± 5.0 and 4.0 ± 2.5 per donors in Corriedale and Bond sheep breeds, respectively. We conclude that this modified technique for ewe superovulation improved animal welfare, reduced animal handling and labour and yielded results similar to or better than conventional twice-daily follicle stimulating hormone treatments.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

Panyaboriban¹,

Suwimonteerabutr²,

Swangchan-Uthai³

et al. 2018

Vet. Med. - Czech

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“…Similarly, Yamamoto et al [21] reported that a FSH-R dose level of 20 mg may be more effective in Holstein heifers. Furthermore McGowan et al [13] studied the dose-response relationship for hMG in the range of 262.5 IU-2,100 IU for the superovulatory response in crossbred beef heifers and concluded that 1,050 IU hMG was the optimum dose of hMG.…”

mentioning

confidence: 99%

Use of Highly Purified Porcine FSH Preparation for Superovulation in Japanese Black Cattle.

Sugano¹,

Watanabe²

1997

The Journal of Veterinary Medical Science

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ABSTRACT. Fifty cattle were divided into 3 groups (I, II, III) according to FSH-R dosage used to induce superovulation between days 9 and 11 of the estrous cycle. Ova/embryo recovery rate did not differ significantly between groups I and II administered total dosages of 16 and 24 mg, respectively. However, the average number of recovered ova/embryos and transferable embryos was significantly lower in group III (administered a total dosage of 30 mg) (P<0.05) than groups I and II. These results suggest that intramuscular administration of 16 mg FSH-R over 3 days is sufficient for inducing superovulation in Japanese Black cattle. -KEY WORDS: FSH-R, Japanese Black cattle, superovulation.

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“…Importantly, it was also implied that the possibility of overstimulation by traditional methods and low-dose gonadotropins, could help lead to repeat stimulations for one animal in one breeding season. We conclude that PVP is safe for use, based on the fact that it is not only widely used in animal superovulation [Dattena et al, 1994;D'Alessandro et al, 2001;Jackson et al, 2006;Kanayama et al, 1992Kanayama et al, , 1994Satoh et al, 1996;Sugano and Shinogi, 1999;Takedomi et al, 1995;Yamamoto et al, 1994], but also used in food, medical and cosmetics as inactive additives that have been approved by FDA in USA. In this study inflammation and tissue swelling were not observed at the treatment sites or their vicinity, when treatments were done using PVP as a solvent for rhFSH.…”

Section: Discussionmentioning

confidence: 91%

“…Because the first report that superovulation could be brought about by one or two injections of 5 mg FSH dissolved in 30% PVP, resulting in multiple births in cows [Smith et al, 1973], many studies have used PVP solution as a solvent to prolong the action of FSH to achieve superovulation in rabbits [Kanayama et al, 1992[Kanayama et al, , 1994, cows [Satoh et al, 1996;Sugano & Shinogi, 1999;Takedomi et al, 1995;Yamamoto et al, 1994], gilts [Jackson et al, 2006] and sheep [Dattena et al, 1994;D'Alessandro et al, 2001]. Compared with the conventional Superscripts ''T'' indicates animals were treated twice-daily with the indicated dose of rhFSH for 8 days; and ''S'' indicates animals were treated single-daily with the indicated dose of rhFSH for 9 days.…”

Section: Discussionmentioning

confidence: 99%

Superovulatory response to a low dose single‐daily treatment of rhFSH dissolved in polyvinylpyrrolidone in rhesus monkeys

Yang

Hildebrandt

et al. 2007

American J Primatol

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To simplify the procedure for superovulation in the rhesus monkey, this study was designed using polyvinylpyrrolidone (PVP) solution as a solvent for gonadotropins. Thirty-five cycling females (aged 5-8 years old) were divided into six groups during the breeding season (November- February). The groups were as follows: Group I, animals received twice-daily 35 IU recombinant human follicle-stimulating hormone (rhFSH) dissolved in 0.5 ml saline for 8 days as the control; Groups II and III, animals received single-daily 35 IU and 17 IU rhFSH in 0.5 saline, respectively, for 9 days; Groups IV, V and VI, received single-daily injection of 35 IU rhFSH, 17 IU rhFSH and 8.5 IU rhFSH dissolved in 0.5 ml 30% PVP (w/v) solution, respectively, for 9 days. After human chorionic gonadotropin was administered to induce the nuclear maturation of oocytes, oocytes were retrieved and the development competence of recovered oocytes treated with in vitro fertilization were observed. The plasma concentrations of follicle-stimulating hormone and ovarian responses were monitored during the treatment. The results showed that the number of recovered oocytes and the in vitro developmental competence of mature oocytes was equivalent among monkeys when treated with a single-daily treatment of 17 and 35 IU rhFSH with PVP preparation in Groups IV and V compared with the twice-daily 35 IU rhFSH treatments received by Group I. However, almost all animals in Groups II, III and VI responded poorly to corresponding stimulations. These findings indicate that a single-daily low dose of rhFSH dissolved in PVP solution can induce the satisfactory ovarian responses in rhesus monkeys. This has the potential to reduce treatment distress, stress to the animals, the labor of the operator as well as the amount of rhFSH used in ovarian stimulation, compared with traditional superovulation methods.

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Superovulation in the cow with a single intramuscular injection of FSH dissolved in polyvinylpyrrolidone

Cited by 41 publications

References 13 publications

A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

A simplified superovulation protocol using split-single administration of Folltropin®-V in hyaluronan: application to purebred sheep

Use of Highly Purified Porcine FSH Preparation for Superovulation in Japanese Black Cattle.

Superovulatory response to a low dose single‐daily treatment of rhFSH dissolved in polyvinylpyrrolidone in rhesus monkeys

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