Supernumerary Molars and Wisdom Tooth Shape Alterations in Patients with Neurofibromatosis Type 1

Abstract

ObjectivesThe purpose of the present study was the systematic investigation of numerical and morphological aberrations of teeth in the wisdom teeth region in neurofibromatosis type 1 patients.Material and MethodsThe panoramic radiographs of 179 patients were analysed for supernumerary molars and dysplastic wisdom teeth with special reference to facial tumour type. The results were compared to radiographic findings obtained in panoramic radiographs of age- and sex-matched controls.ResultsThe total number of dysplastic or supernumerary molars was 21 (17 individuals, 4.75%) and predominantly a finding of the maxilla (maxilla: 15, mandible: 1, maxilla and mandible: 1). Differences of dental findings between neurofibromatosis type 1 (NF1) patients (n = 15) and the control group (n = 2) were statistically significant (P < 0.01). All individuals with supernumerary molars were diagnosed as being affected with NF1. This difference achieved statistical significance when it was considered that the event may occur at least once per quadrant, and thus the individual potentially needs to be considered four times (P = 0.0038).ConclusionsThis investigation revealed that supernumerary molars and aberrations in wisdom tooth form are more common in patients than in age- and sex-matched controls. There is no association between these findings and a specific feature of the disease, id est facial manifestation of a trigeminal nerve sheath tumour (plexiform neurofibroma). The cause of this phenomenon is unknown. A review of these dental findings on other neurofibromatosis type 1 study groups should be attempted.

Paramolares bilaterales maxilares no erupcionados y su abordaje quirúrgico: reporte de un caso inusual

“…La prevalencia de dientes supernumerarios varía según los estudios debido a la metodología que se haya seguido, el tamaño de la muestra, los grupos de edad, etnia, y técnicas radiográficas aplicadas. Respecto a los paramolares, algunos estudios indican una prevalencia menor al 0,20%, 20,21 incluso una investigación realizada para establecer la frecuencia de dientes supernumerarios en una muestra de 2000 sujetos en España no reportó presencia de algún paramolar 22 al igual que otro estudio realizado sobre la frecuencia de supernumerarios observados en tomografías en el cual, tampoco se hallaron dientes paramolares. 19 Respecto al sexo, la mayoría de los reportes casos, así como los estudios de prevalencia de supernumerarios indican que los dientes paramolares se presentan más en hombres que en mujeres, dicha situación no se dio en este caso.…”

“…19 Respecto al sexo, la mayoría de los reportes casos, así como los estudios de prevalencia de supernumerarios indican que los dientes paramolares se presentan más en hombres que en mujeres, dicha situación no se dio en este caso. 14,19,21,23 Investigaciones realizadas por Santos et al 12 y Martinez-Gonzalez et al 19 mencionan que los dientes supernumerarios retenidos pueden asociarse a quistes o agrandamiento del folículo de hasta 3 mm, en el caso presentado, en ninguno de los paramolares se observó dicha condición.…”

A typical neurofibromatosis type 1 in adult with intracranial T2 hyperintensities and pinealoma: A Case Report

“…But there were researches about supernumerary molars and aberrations in wisdom tooth form in NF-1 patients [3]. The cause of the tooth anomalies is unknown but it might have some association with low bone-mineral densities and osteoclast activation [3,4]. More researches on bone metabolism in NF-1 are in demand.…”

An Overview of Retrospective Studies on Distomolar Teeth in Turkish Population and 4 Case Reports

“…Supernumerary teeth can be observed along with syndromes such as Gardner syndrome, Ehler-Danlos syndrome, Fabry-Anderson syndrome, Cleidocranial Dysostosis, or Neurofibromatosis type I, but also mostly occur as isolated phenomena in nonsyndromic diseases [1,21,50]. While no other syndrome has been observed in a patient, it is rare that supernumerary teeth occur in abundance or in more than one quadrant [7,16,51].…”