Superiority of combined magnesium (MG) and vitamin B6 (VITB6) supplementation over magnesium alone on severe stress in adults with low magnesemia: A randomised, single blind trial

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

“…Since aluminum is widespread in modern day society (such as in cookware, deodorants, over the counter and prescription drugs, powder, baked products, and others), this could represent an important contributor to magnesium deficiency [ 18 ]; Peptides from casein or whey could bind magnesium, which may promote absorption, analogously to other divalent cations [ 179 ]. A low protein intake (<30 g/die) could negatively influence the absorption of magnesium, however, other studies showed that magnesium use was not affected by the level of protein intake [ 180 ]; Vitamin D seems to have a favorable role on Mg 2+ absorption [ 14 , 85 , 181 , 182 ] and Mg 2+ is important for vitamin D activation and inactivation [ 85 ]; Vitamin B6 collaborates with magnesium in many enzyme systems and increases the accumulation of intracellular magnesium; a vitamin B6-deficient diet can lead to a negative magnesium balance via increased magnesium excretion [ 183 , 184 ]; High doses of zinc can interfere with magnesium. Nielsen et al reported that an intake of 53 mg zinc/day (4-fold higher than LARN) over 90 days can decrease magnesium balance [ 185 ]; As for beverages, magnesium levels are decreased by excess ethanol, soft drinks, and coffee intake [ 186 ]; Some drugs negatively affect the state of magnesium, in particular diuretics, insulin, and digitalis [ 23 ].…”

“…Vitamin B6 collaborates with magnesium in many enzyme systems and increases the accumulation of intracellular magnesium; a vitamin B6-deficient diet can lead to a negative magnesium balance via increased magnesium excretion [ 183 , 184 ];…”