Superior Vena Cava Tumoral Thrombosis Revealing a Burkitt's Lymphoma and a Lymphoblastic Non-Hodgkin's Lymphoma

Abstract

Superior vena cava thrombosis (SVCT) is a rare pathology, though of great significance since it implies the development of a malignant process. The most common etiologies are basically bronchopulmonary and mediastinal tumors. Observations involving 2 patients presenting with superior vena cava syndrome (SVCS) are reported in this study, in which radiologic investigations (chest roentgenogram, computed tomography scan of the thorax, and superior vena cavography) revealed thrombosis of the SVC disclosing in both cases a non-Hodgkin's lymphoma. The first case was a mediastinal Burkitt's lymphoma in a thirty-eight-year-old man (exceptional form) and in the second case a lymphoblastic non-Hodgkin's lymphoma in a nine-year-old girl. In the patient with Burkitt's lymphoma healing was satisfactory twenty-four months after treatment by surgery, chemotherapy, and radiotherapy. The second patient died suddenly. In both cases the SVCT revealed the tumor. The causes of SVCT are reviewed and discussed.

Surgical Treatment of an Endovascular Metastatic Melanoma of The Superior Vena cava

“…The cause of blockage is either external compression, local infiltration into a vein or an intravenous thrombosis. Malignant tumors such as bronchogenic carcinoma (especially small-cell carcinoma) and lymphoma are responsible for approximately 85–90% of all cases of SVCS due to extraluminal compression [3]. Metastatic thrombosis leading to SVCS accounts for only 4–7% of cases and concerns adenocarcinoma of the breast, kidney, colon, thyroid, prostate and various types of malignant testicular tumors [4].…”

Mediastinal Burkitt lymphoma in childhood

“…Burkitt lymphoma (BL) accounts for approximately 40% of childhood non‐Hodgkin lymphoma (NHL) . Mediastinal involvement, more frequent in Hodgkin lymphoma (HL), and large B‐cell lymphoma (LBCL), is exceptional in BL, with anecdotal cases reported . We reviewed our database to identify all cases of BL with mediastinal localization at the diagnosis.…”

Gesichtsödeme bei einem 61-jährigen Patienten

“…Hier steht das kleinzellige Bronchialkarzinom an erster Stelle, das entsprechend der Kreuzung der V. cava superior mit dem rechten Hauptbronchus in diesen Fällen vorwiegend in der rechten Lunge lokalisiert ist [15,24,36]. Aber auch andere Tumoren wie Lymphome (u. a. intrathorakales Plasmozytom, Burkitt-Lymphom), primär mediastinale Tumoren wie Thymome und mediastinale Lymphknotenmetastasen extrathorakaler Primärtumoren wie das metastasierende maligne Melanom, Nieren-, Pharynx-, Blasen-, Uterus-, Ovarial-und Mammakarzinome sind in diesem Zusammenhang zu nennen [5,7,13,15,19,20,31]. Es gibt Untersuchungen, nach denen etwa 8% aller Patienten mit Bronchialkarzinom im Verlauf ihrer malignen Grunderkrankung eine manifeste obere Einflussstauung entwickeln können [34].…”