Superior Vena Cava Syndrome: A Presenting Feature of Mediastinal Germ Cell Tumor

Roy, Mahua; Bandyopadhyay, Rajat; Pandit, Narayan; Sengupta, Soumita Ghosh

doi:10.5001/omj.2010.35

Cited by 5 publications

(7 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SVC syndrome mostly occurs due to lymphomas among pediatric malignancies, whereas it rarely occurs due to the GCTs. In addition to two cases reported to have SVC syndrome due to GCT [22][23], in their studies, Schneider et al [2] reported SVC syndrome in five of 53 patients. Lack et al [7] reported SVC syndrome in one of 21 patients.…”

Section: Mediastinal Germ Cell Tumors In Childhood mentioning

confidence: 95%

Mediastinal Germ Cell Tumors in Childhood

Yalçın

Demir

Tanyel

et al. 2012

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

show abstract

Section: Mediastinal Germ Cell Tumors In Childhood mentioning

confidence: 95%

Mediastinal Germ Cell Tumors in Childhood

Yalçın

Demir

Tanyel

et al. 2012

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

show abstract

“…Diagnostic workup includes CBC with peripheral smear, flow-cytometry, tumor markers, bone marrow aspirate and trephine biopsy, lymph node biopsy, CXR, CT chest, and echocardiography imaging studies. 2 , 6 During sedation, particularly before intubation, it is important to remember that anesthesia may lead to increase venous capacitance, decreasing preload that would in turn acutely reduce cardiac output and may lead to hypotension and cardiac arrest. In addition, SVC occlusion and pulmonary artery compression may lead to cardiovascular collapse with a substantial risk of death.…”

Section: Discussionmentioning

confidence: 99%

Superior Mediastinal Syndrome Misdiagnosed as Foreign Body Aspiration: A Case Report

Qureshi¹,

Beg²,

Haider³

et al. 2023

Oman Med J

View full text Add to dashboard Cite

Superior mediastinal syndrome is a life-threatening pediatric oncological emergency that requires high level of awareness and clinical suspicion to avoid misdiagnosis and devastating outcomes. Early diagnostic evaluation and management of underlying etiology are of utmost significance for optimal results. In children, it is most commonly caused by non-Hodgkin’s lymphoma and T-cell lymphoblastic leukemia. We report a case of a six-year-old boy with superior mediastinal syndrome secondary to T-cell acute lymphoblastic leukemia, initially misdiagnosed as foreign body aspiration and underwent a procedure with a life-threatening outcome.

show abstract

“…Surgical excision is the treatment of choice in nonseminomatous tumors and a radical extirpation results in a long recurrence-free-survival 7,16 . The postoperative irradiation therapy should be applied if a residual disease or nodal metastases are registered, whereas the preoperative irradiation therapy is indicated if there is evidence of the chest wall involvement 3 .…”

Section: Discussionmentioning

confidence: 99%

“…The postoperative irradiation therapy should be applied if a residual disease or nodal metastases are registered, whereas the preoperative irradiation therapy is indicated if there is evidence of the chest wall involvement 3 . Recommended chemotherapy protocols include PVB (cisplatin, vinbalstin, bleomycin), PEB (cisplatin, etoposide, bleomycin) and JEB (carboplatin, etoposide, bleomycin) 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Germ cell tumors are classified as extragonadal tumors when there is no presence of primary tumors of testes or ovary. The most common localization of extragonadal tumors in adults are pineal gland, mediastinum and retroperitoneum [5][6][7] . Teratoma is a common tumor of the anterior mediastinum and malignant teratoma seldom metastasizes to the lung.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary malignant teratoma of the mediastinum with poor outcome: A case report

Sazdanic-Velikic¹,

Škrbić²,

Povazan³

et al. 2018

VOJNOSANIT PREGL

View full text Add to dashboard Cite

Introduction. About 5%-10% of mediastinal tumors in adults are teratomas and about 85% of them are benign. Case report. We report a case of extragonadal malignant teratoma in a 39-year old man. The computed tomography (CT) scan of the chest revealed the soft-tissue density mass in the middle lobe of the lung. The posterolateral thoracotomy was performed and a mediastinal tumor of 25 cm was completely resected. Histopathological findings confirmed malignant teratoma. One month after the resection the positron emission tomography-computed tomography (PET/CT) scan of the whole body was performed and showed progression of the disease. Patient developed signs of the superior vena cava obstruction and received radiotherapy of the mediastinum and the metastatic lesion of the lumbal vertebra. After radiotherapy, the patient developed paraplegia and urinary incontinence and received the best supportive treatment. Conclusion. Primary extragonadal germ cell tumors have poor prognosis due to their relative chemoresistance and frequent findings of advanced disease after establishing the diagnosis.

show abstract

Superior Vena Cava Syndrome: A Presenting Feature of Mediastinal Germ Cell Tumor

Cited by 5 publications

References 6 publications

Mediastinal Germ Cell Tumors in Childhood

Mediastinal Germ Cell Tumors in Childhood

Superior Mediastinal Syndrome Misdiagnosed as Foreign Body Aspiration: A Case Report

Primary malignant teratoma of the mediastinum with poor outcome: A case report

Contact Info

Product

Resources

About