Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study

Boddaert, Nathalie; Chabane, Nadia; Gervais, Hélène; Good, Catriona D.; Bourgeois, Marie; Plumet, Marie‐Hélène; Barthélémy, Catherine; Mouren, Marie–Christine; Artiges, Éric; Samson, Yves; Brunelle, Françis; Frackowiak, R. S. J.; Zilbovicius, Mônica

doi:10.1016/j.neuroimage.2004.06.016

Cited by 414 publications

(272 citation statements)

References 45 publications

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“…This is in accord with many previous VBM studies (Abell et al 1999;Boddaert et al 2004;Brieber et al 2007;Salmond et al 2007;Ke et al 2009;Dziobek et al 2010;Kosaka et al 2010;Toal et al 2010;Riva et al 2011;Via et al 2011;Yu et al 2011). However, other studies have found gray matter increases in some of these and other regions in ASD, making the current picture on structural brain differences in ASD somewhat inconsistent (Amaral et al 2008).…”

Section: Regional Gray Matter Abnormalities and Their Correlation Witsupporting

confidence: 87%

“…This step enables the comparison of relative differences in regional gray matter volumes, corrected for individual brain size. Modulated gray matter segments were then smoothed using a Gaussian kernel with a typical value of 12-mm full-width at half-maximum (Abell et al 1999;Boddaert et al 2004;Salmond et al 2005;Brieber et al 2007;Salmond et al 2007;Kanai et al 2012a). …”

Section: Image Preprocessingmentioning

confidence: 99%

“…Interestingly, morphological changes such as reduced gray matter volume have been reported in ASD in both these regions (Boddaert et al 2004;Brieber et al 2007;Salmond et al 2007;Ke et al 2009;Toal et al 2010;Via et al 2011;Yu et al 2011). The question arises whether the variation of social behavior deficits and of other behavioral aspects of ASD can be related to the morphology of brain regions associated with the disorder.…”

mentioning

confidence: 99%

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Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

David

Schultz

Milne

et al. 2013

J Autism Dev Disord

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Individuals with an autism spectrum disorder (ASD) show hallmark deficits in social perception. These difficulties might also reflect fundamental deficits in integrating visual signals. We contrasted predictions of a social perception and a spatialndash;temporal integration deficit account. Participants with ASD and matched controls performed two tasks: the first required spatiotemporal integration of global motion signals without social meaning, the second required processing of socially relevant local motion. The ASD group only showed differences to controls in social motion evaluation. In addition, gray matter volume in the temporalndash;parietal junction correlated positively with accuracy in social motion perception in the ASD group. Our findings suggest that socialndash;perceptual difficulties in ASD cannot be reduced to deficits in spatialndash;temporal integration

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Section: Regional Gray Matter Abnormalities and Their Correlation Witsupporting

confidence: 87%

Section: Image Preprocessingmentioning

confidence: 99%

mentioning

confidence: 99%

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Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

David

Schultz

Milne

et al. 2013

J Autism Dev Disord

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“…Obviously, the present results do not exclude abnormal multimodal integration at later processing stages, which involve other brain areas, such as the such as the superior temporal sulcus (STS) (e.g. Boddaert et al, 2004). It should be noted that the precise mechanisms of the auditory-visual illusion are not yet established.…”

Section: Discussioncontrasting

confidence: 74%

Brief Report: Can You See What is Not There? Low-level Auditory–visual Integration in Autism Spectrum Disorder

Smagt

Engeland

Kemner

2007

J Autism Dev Disord

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Patients diagnosed with Autism Spectrum Disorder, show impaired integration of information across different senses. The processing-level from which this impairment originates, however, remains unclear. We investigated low-level integration of auditory and visual stimuli in subjects with Autism Spectrum Disorder. High-functioning adult subjects with Autism Spectrum Disorder as well as age-and IQ-matched adults were tested using a task that evokes illusory visual stimuli, by presenting sounds concurrently with visual flashes. In both groups the number of sounds presented significantly affected the number of flashes perceived, yet there was no difference between groups. This finding implicates that any problems arising from integrating auditory and visual information must stem from higher processing stages in high-functioning adults with Autism Spectrum Disorder.

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“…A voxel-based morphometry analysis of the brains of children with ASD (mean age 15.4 ± 2.2 std) compared to IQ matched controls (mean age 15.5 ± 1.6 std) found total brain gray matter volume increases and localized increases that included the right superior temporal gyrus [62]. Also using voxel-based morphometry, Boddaert et al (2004) found contrary results in children with ASD (mean age 9.3 ± 2.2 std), with decreases of grey matter volume localized to the STS compared to healthy controls (mean age 10.8 ± 2.7 std) [63]. This discrepancy between studies may reflect differences in the age range or choice of controls.…”

Section: The Neural Basis Of Anomalous Gaze Processing In Asdmentioning

confidence: 98%

Autism and the development of face processing

Golarai

Grill-Spector

Reiss

2006

Clinical Neuroscience Research

157

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Autism is a pervasive developmental condition, characterized by impairments in non-verbal communication, social relationships and stereotypical patterns of behavior. A large body of evidence suggests that several aspects of face processing are impaired in autism, including anomalies in gaze processing, memory for facial identity and recognition of facial expressions of emotion. In search of neural markers of anomalous face processing in autism, much interest has focused on a network of brain regions that are implicated in social cognition and face processing. In this review, we will focus on three such regions, namely the STS for its role in processing gaze and facial movements, the FFA in face detection and identification and the amygdala in processing facial expressions of emotion. Much evidence suggests that a better understanding of the normal development of these specialized regions is essential for discovering the neural bases of face processing anomalies in autism. Thus, we will also examine the available literature on the normal development of face processing. Key unknowns in this research area are the neuro-developmental processes, the role of experience and the interactions among components of the face processing system in shaping each of the specialized regions for processing faces during normal development and in autism. Published by Elsevier B.V. on behalf of Association for Research in Nervous and Mental Disease.

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Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study

Cited by 414 publications

References 45 publications

Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

Right Temporoparietal Gray Matter Predicts Accuracy of Social Perception in the Autism Spectrum

Brief Report: Can You See What is Not There? Low-level Auditory–visual Integration in Autism Spectrum Disorder

Autism and the development of face processing

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