Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder

Takahashi, Tsutomu; Chanen, Andrew M; Wood, Stephen J.; Yücel, Murat; Kawasaki, Yasuhiro; McGorry, Patrick D.; Suzuki, Michio; Velakoulis, Dennis; Pantelis, Christos

doi:10.1016/j.pscychresns.2009.10.014

Cited by 14 publications

(8 citation statements)

References 25 publications

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“…In a subsequent study led by Takahashi (Takahashi et al, 2010), BPD patients and healthy controls did not significantly differ in superior temporal gyrus (STG) volumes (p>.05). BPD patients with a history of violent episodes, however, had a smaller left caudal STG volume than those without violent histories (F 4, 72 = 2.81, p=.032).…”

Section: Other Brain Regionsmentioning

confidence: 91%

“…Eight studies were derived from the Orygen Youth Health Research Centre in Melbourne (Chanen, Velakoulis, et al, 2008;Garner et al, 2007;Jovev et al, 2008;Takahashi, Chanen, Wood, Walterfang, et al, 2009;Takahashi et al, 2010;Takahashi, Chanen, Wood, Yücel, et al, 2009;Walterfang et al, 2010;Whittle et al, 2009) and three from the University of Heidelberg Maier-Hein et al, 2014;. These two study groups used the same respective cohort of patients for each study, but examined different brain structures or utilised varying imaging technologies.…”

Section: Brain Structuresmentioning

confidence: 99%

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A systematic review of the neurobiological underpinnings of borderline personality disorder (BPD) in childhood and adolescence

Winsper

Marwaha

Lereya

et al. 2016

Reviews in the Neurosciences

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AbstractContemporary theories for the aetiology of borderline personality disorder (BPD) take a lifespan approach asserting that inborn biological predisposition is potentiated across development by environmental risk factors. In this review, we present and critically evaluate evidence on the neurobiology of BPD in childhood and adolescence, compare this evidence to the adult literature, and contextualise within a neurodevelopmental framework. A systematic review was conducted to identify studies examining the neurobiological (i.e. genetic, structural neuroimaging, neurophysiological, and neuropsychological) correlates of BPD symptoms in children and adolescents aged 19 years or under. We identified, quality assessed, and narratively summarised 34 studies published between 1980 and June 2016. Similar to findings in adult populations, twin studies indicated moderate to high levels of heritability of BPD, and there was some evidence for gene-environment interactions. Also consistent with adult reports is that some adolescents with BPD demonstrated structural (grey and white matter) alterations in frontolimbic regions and neuropsychological abnormalities (i.e. reduced executive function and disturbances in social cognition). These findings suggest that neurobiological abnormalities observed in adult BPD may not solely be the consequence of chronic morbidity or prolonged medication use. They also provide tentative support for neurodevelopmental theories of BPD by demonstrating that neurobiological markers may be observed from childhood onwards and interact with environmental factors to increase risk of BPD in young populations. Prospective studies with a range of repeated measures are now required to elucidate the temporal unfurling of neurobiological features and further delineate the complex pathways to BPD.

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Section: Other Brain Regionsmentioning

confidence: 91%

Section: Brain Structuresmentioning

confidence: 99%

A systematic review of the neurobiological underpinnings of borderline personality disorder (BPD) in childhood and adolescence

Winsper

Marwaha

Lereya

et al. 2016

Reviews in the Neurosciences

View full text Add to dashboard Cite

show abstract

“…On the other hand, while gray matter changes of the STG and insula in first‐episode schizophrenia seem to be rather disease‐specific among various psychotic disorders (e.g., affective psychosis and schizophreniform disorder), gross morphologic features, such as the size of midline structures and olfactory sulcus depth did not differ between schizophrenia and other psychosis subgroups. Further, patients with other neuropsychiatric disorders, such as major depression, bipolar disorder, and borderline personality disorder, are likely to exhibit similar gross morphologic and gray matter changes (e.g., frontal and temporo‐limbic atrophy) to those reported in schizophrenia patients. Thus, the MRI findings in schizophrenia are supposed to include both those specific to schizophrenia and those more generally observed across various neuropsychiatric disorders.…”

Section: Possible Clinical Applicability and Future Directionsmentioning

confidence: 99%

Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention

Takahashi

Suzuki

2018

Psychiatry Clin Neurosci

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To date, a large number of magnetic resonance imaging (MRI) studies have been conducted in schizophrenia, which generally demonstrate gray matter reduction, predominantly in the frontal and temporo-limbic regions, as well as gross brain abnormalities (e.g., a deviated sulcogyral pattern). Although the causes as well as timing and course of these findings remain elusive, these morphologic changes (especially gross brain abnormalities and medial temporal lobe atrophy) are likely present at illness onset, possibly reflecting early neurodevelopmental abnormalities. In addition, longitudinal MRI studies suggest that patients with schizophrenia and related psychoses also have progressive gray matter reduction during the transition period from prodrome to overt psychosis, as well as initial periods after psychosis onset, while such changes may become almost stable in the chronic stage. These active brain changes during the early phases seem to be relevant to the development of clinical symptoms in a region-specific manner (e.g., superior temporal gyrus atrophy and positive psychotic symptoms), but may be at least partly ameliorated by antipsychotic medication. Recently, increasing evidence from MRI findings in individuals at risk for developing psychosis has suggested that those who subsequently develop psychosis have baseline brain changes, which could be at least partly predictive of later transition into psychosis. In this article, we selectively review previous MRI findings during the course of psychosis and also refer to the possible clinical applicability of these neuroimaging research findings, especially in the diagnosis of schizophrenia and early intervention for psychosis.

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“…Furthermore, previous magnetic resonance imaging (MRI) studies have reported that BPD patients exhibit brain morphological characteristics associated with fetal neurodevelopmental abnormalities (e.g., altered sulco-gyral patterns and hyper- or hypo-gyrification) at early stages of the illness ( 14 – 18 ). While our previous MRI study found no volume changes of HG in a BPD cohort and its clinical subgroups (e.g., with and without violent episodes) ( 19 ), no MRI studies have specifically investigated HG duplication patterns in BPD.…”

Section: Introductionmentioning

confidence: 75%

Heschl’s gyrus duplication pattern and clinical characteristics in borderline personality disorder: A preliminary study

Takahashi

Sasabayashi²,

Velakoulis³

et al. 2022

Front. Psychiatry

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Inter-individual variations in the sulco-gyral pattern of Heschl’s gyrus (HG) might contribute to emotional processing. However, it remains largely unknown whether borderline personality disorder (BPD) patients exhibit an altered HG gyrification pattern, compared with healthy individuals, and whether such a brain morphological feature, if present, might contribute to their clinical characteristics. The present study used magnetic resonance imaging to investigate the distribution of HG gyrification patterns (single or duplicated) and their relationship to clinical characteristics in teenage BPD patients with minimal treatment exposure. No significant difference was noted for the prevalence of HG patterns between 20 BPD and 20 healthy participants. However, the BPD participants with left duplicated HG were characterized by higher prevalence of comorbid disruptive behavior disorders, with higher externalizing score compared with those with left single HG. Our preliminary results suggest that neurodevelopmental pathology associated with gyral formation might be implicated in the neurobiology of early BPD, especially for emotional and behavioral control.

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Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder

Cited by 14 publications

References 25 publications

A systematic review of the neurobiological underpinnings of borderline personality disorder (BPD) in childhood and adolescence

A systematic review of the neurobiological underpinnings of borderline personality disorder (BPD) in childhood and adolescence

Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention

Heschl’s gyrus duplication pattern and clinical characteristics in borderline personality disorder: A preliminary study

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