Superior suppression of serum estrogens during neoadjuvant breast cancer treatment with letrozole compared to exemestane
Bjørn-Erik Bertelsen,
Bjørg Almås,
Kamilla Fjermeros
et al.
Abstract:Purpose
The aromatase inhibitor letrozole and the aromatase inactivator exemestane are two of the most pivotal cancer drugs used for endocrine treatment of ER-positive breast cancer in all phases of the disease. Although both drugs inhibit CYP19 (aromatase) and have been used for decades, a direct head-to-head, intra-patient-cross-over comparison of their ability to decrease estrogen synthesis in vivo is still lacking.
Methods
Postmenopausal breast cancer … Show more
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