Superior sagittal sinus thrombosis in a patient with protein S deficiency.

Cros, Didier; Beltran, German; Gum, Gregory K.

doi:10.1161/01.str.21.4.633

Cited by 35 publications

(6 citation statements)

References 15 publications

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“…Coagulation abnormalities (antithrombin III deficiency, C and S protein deficiency, lupus anticoagulant) have previously been reported in patients with cerebral thrombophlebitis [9, 10, 11]. Our 3 patients had normal levels for antithrombin 3, C and S protein and no lupus anticoagulant was found.…”

Section: Discussionsupporting

confidence: 51%

Cerebral Thrombophlebitis in Three Patients with Probable Multiple Sclerosis

et al. 1999

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We report 3 cases of young patients, 2 women and 1 man, who presented a cerebral venous thrombosis following intravenous treatment with high doses of corticosteroids. All of them presented a probable multiple sclerosis according to clinical, biological (CSF) and MRI criteria and were treated for the first time by a bolus of 1,000 mg of methylprednisolone OD during 5 days. All the usual causes of cerebral venous thrombosis were systematically excluded in all of them. The role of corticosteroid treatment in cerebral thrombophlebitis is discussed. All of them underwent a lumbar puncture a few days before corticosteroid treatment and the relationship between lumbar puncture and cerebral thrombophlebitis is also discussed. Cerebral venous thrombosis associated with corticosteroid treatment has rarely been reported. The relationship between corticosteroids and venous thrombosis has already been suggested but has never been clearly understood.

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Section: Discussionsupporting

confidence: 51%

Cerebral Thrombophlebitis in Three Patients with Probable Multiple Sclerosis

et al. 1999

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“…Several cases of protein S deficiency have been reported in association with thrombotic stroke [11, 12, 13, 14, 15]. Our patient had low protein S activity and decreased total and free protein S with a normal C4b binding protein, defined as Type I, or quantitative, protein S deficiency [16].…”

Section: Discussionmentioning

confidence: 86%

Protein S Deficiency, Activated Protein C Resistance and Sticky Platelet Syndrome in a Young Woman with Bilateral Strokes

Chaturvedi

Dzieczkowski

1999

Cerebrovasc Dis

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Background: Coagulation disorders are common in young adults (age less than 55 years) with ischemic stroke. Objectives: To describe a young woman with bilateral strokes of undetermined etiology who had three significant hemostatic disturbances. These were protein S deficiency, Factor V Leiden heterozygosity, and sticky platelet syndrome. The Factor V Leiden mutation was also present in one of her children. Conclusions: Young patients with cryptogenic stroke warrant a thorough evaluation for hypercoagulable states. More than one coagulation disorder can coexist in the same patient and the spectrum of hemostatic abnormalities may influence the patient’s treatment and may have implications for screening of other family members.

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“…It is important to confirm PS deficiency 3 months after the CVT because acquired deficiencies may be present during the acute phase of thrombosis or because these patients may be pregnant or taking contraceptive medications. 15 Protein C (PC) and antithrombin III deficiencies have also been associated with CVT. Overall, approximately 30 cases of CVT are reported in association with antithrombin, PC and PS deficiencies.…”

Section: Causesmentioning

confidence: 99%