Superior Parietal Cortex Activation During Spatial Attention Shifts and Visual Feature Conjunction

Corbetta, Maurizio; Shulman, Gordon L.; Miezin, Francis M.; Petersen, Steven E.

doi:10.1126/science.270.5237.802

Cited by 672 publications

(460 citation statements)

References 21 publications

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“…However, this effect was more pronounced when the left visual hemi®eld was attended. Such a hemispheric asymmetry has been frequently reported in spatial visual attention tasks using VEPs (Palmer and Tzeng, 1990;Posner and Petersen, 1990;Posner and Dehaene, 1994;Heilman, 1995) and PET (Corbetta et al, 1993(Corbetta et al, , 1995. In their study, Corbetta et al (1993) reported an asymmetrical activation of the parietal cortex when attending the left or right visual ®eld.…”

Section: Discussionsupporting

confidence: 55%

Selective visual-spatial attention alters induced gamma band responses in the human EEG

Gruber

Müller

Keil

et al. 1999

Clinical Neurophysiology

313

168

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Objectives: The present study was designed to investigate the attentional modulation of gamma band responses in a visual spatial attention task using a 128-channel-EEG-montage.Methods: Colored rectangles were presented on a screen. After 500 ms an arrow indicated whether subjects had to shift their attention to the left or right half of the screen to detect target stimuli. During the task, either the attended half of the screen rotated horizontally while the unattended part remained motionless, or vice versa.Results: When subjects attended the rotating stimulus, we found signi®cantly higher power in a speci®c gamma band from 35±51 Hz on parieto-occipital electrode sites contralateral to the stimulation side. In addition, after the onset of the arrow which indicated what side subjects should direct their attention to, the 35±51 Hz response shifted from a broad posterior distribution to an increase of power at parietooccipital sites contralateral to the to-be-attended side. Furthermore, the rotating stimulus elicited higher gamma band power as compared to the standing stimulus at electrode locations, which may be related to the activity of underlying cortical structures specialized for motion processing.Conclusions: The present results replicate important parts of previous ®ndings of enhanced gamma power when a moving stimulus was attended. q

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Section: Discussionsupporting

confidence: 55%

Selective visual-spatial attention alters induced gamma band responses in the human EEG

Gruber

Müller

Keil

et al. 1999

Clinical Neurophysiology

313

168

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“…However, recently, Luo, Greenwood, and Parasuraman (2001) found that shifts in the spatial scale of attention, as elicited by variations in cue size in a search task, modulated early-latency ERP components (P1 and N1) recorded from scalp regions overlying posterior cortical areas. These results indicate that the spatial scale of attention also acts as a sensory gain control mechanism, as does attention shifting.Using PET in an uncued search task, Corbetta et al (1995) found that in comparison to feature search, conjunction search was associated with activation of the parietal lobe in a region closely overlapping the same region they had previously shown to be involved in covert shifts of attention. Furthermore, brain-damaged individuals with deficits in covert orienting are slower to search for targets defined by a conjunction of color and orientation, but are unimpaired for detection of either feature in isolation (Arguin, Joanette, & Cavanagh, 1993).…”

mentioning

confidence: 84%

“…However, most natural visual scenes are not as impoverished as this task. The visual search task provides a better analog to such everyday visual tasks.Behavioral (Treisman, 1996) and neuroimaging studies (Corbetta, Shulman, Miezin, & Petersen, 1995) suggest that the covert attention mechanism also operates in visual search tasks. However, the area containing a target in a search array may be large or small and attention may need to be distributed broadly or narrowly.…”

mentioning

confidence: 99%

The apolipoprotein E gene, attention, and brain function.

Parasuraman¹,

Greenwood²,

Sunderland³

2002

Neuropsychology

108

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The ɛ4 allele of the apolipoprotein E (ApoE) gene is associated with alterations in brain function and is a risk factor for Alzheimer's disease (AD). Changes in components of visuospatial attention with ApoE-ɛ4, aging, and AD are described. Healthy middle-aged adults without dementia who have the ApoE-ɛ4 gene show deficits in spatial attention and working memory that are qualitatively similar to those seen in clinically diagnosed AD patients. The findings support an association between ApoE polymorphism and specific components of visuospatial attention. Molecular mechanisms that may mediate the ApoE-attention link by modulating cholinergic neurotransmission to the posterior parietal cortex are discussed. Studies of attention and brain function in ApoE-ɛ4 carriers without dementia can advance knowledge of the genetics of visual attention, may enhance understanding of the preclinical phase of AD, and may lead to better methods for early AD detection.Apolipoprotein E (ApoE) is an amino acid glycoprotein that is important in lipid storage, transport, and metabolism (Mahley, 1988). Although synthesized mainly in the liver, ApoE is also found in the peripheral and central nervous systems, including the brain. ApoE has long been of interest in medicine, but its importance in neuroscience increased dramatically with the identification of the ɛ4 allele of the ApoE gene on chromosome 19 as a major risk factor for the development of late-onset Alzheimer's disease (AD) in older adults Strittmatter et al., 1993). This discovery led to a growing number of studies examining the role of the ApoE gene in normal brain function and cognition, as well as in disorders such as AD, brain injury, and stroke (Higgins, Large, Rupniak, & Barnes, 1997;Horsburgh, McCarron, White, & Nicol, 2000; J. D. Smith, 2000).Polymorphisms of the ApoE gene are associated with significant alterations in brain morphology (Plassman et al., 1997) and cognitive functioning, including attention (Greenwood, Sunderland, Friz, & Parasuraman, 2000) and memory (Bondi et al., 1995). Studies of ApoE may thus reveal information relevant to the genetics of attention and memory in normal individuals. At the same time, such studies may identify cognitive and neural changes that may be characteristic of preclinical stages of AD. In this article, we review the role of the ApoE gene in normal cognition and in the development of deficits indicative of early AD.Currently, no reliable methods exist for the early detection and treatment of AD. New techniques for preventing, slowing the progression of, and treating AD are being urgently sought. Such efforts would be aided considerably if AD could be detected prior to the clinical diagnosis of AD and before irreversible brain changes occur (Daffner & Scinto, 2000). Postmortem studies show that neuropathological changes occur decades before the onset of NIH Public Access Author ManuscriptNeuropsychology. Author manuscript; available in PMC 2006 January 25. Published in final edited form as:Neuropsychology. 2002 April ; ...

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“…Previous fMRI studies on dimension changes found significant activation of multiple posterior brain areas (e.g., Pollmann et al, 2000: fusiform gyrus, lateral occipital gyrus, superior/middle temporal gyrus, SPL and precuneus; Pollmann et al, 2006: IPS, fusiform gyrus, striate/peristriate cortex and posterior putamen/claustrum) that have been implicated in early attentional processes (Corbetta et al, 1993(Corbetta et al, , 1995(Corbetta et al, , 2000Corbetta & Shulman, 1999;Kelley et al, 2008;Macaluso et al, 2000;Nobre et al, 1997, Vandenberghe et al, 2000Yantis et al, 2002). Hence, it was concluded that dimension changes interfere with attention shifts to the target.…”

Section: Theoretical Implicationsmentioning

confidence: 99%

Distinct neural networks for target feature versus dimension changes in visual search, as revealed by EEG and fMRI

2014

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Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in NeuroImage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. A de nitive version was subsequently published in NeuroImage, 102, Part 2, 15 November 2014, 10.1016/j.neuroimage.2014.08.058. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractIn visual search, responses are slowed, from one trial to the next, both when the target dimension changes (e.g., from a color target to a size target) and when the target feature changes (e.g., from a red target to a green target) relative to being repeated across trials. The present study examined whether such feature and dimension switch costs can be attributed to the same underlying mechanism(s). Contrary to this contention, an EEG study showed that feature changes influenced visual selection of the target (i.e., delayed N2pc onset), whereas dimension changes influenced the later process of response selection (i.e., delayed s-LRP onset). An fMRI study provided convergent evidence for the two-system view: Compared with repetitions, feature changes led to increased activation in the occipital cortex, and superior and inferior parietal lobules, which have been implicated in spatial attention. By contrast, dimension changes led to activation of a frontoposterior network that is primarily linked with response selection (i.e., pre-motor cortex, supplementary motor area and frontal areas). Taken together, the results suggest that feature and dimension switch costs are based on different processes. Specifically, whereas target feature changes delay attention shifts to the target, target dimension changes interfere with later response selection operations.

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Superior Parietal Cortex Activation During Spatial Attention Shifts and Visual Feature Conjunction

Cited by 672 publications

References 21 publications

Selective visual-spatial attention alters induced gamma band responses in the human EEG

Selective visual-spatial attention alters induced gamma band responses in the human EEG

The apolipoprotein E gene, attention, and brain function.

Distinct neural networks for target feature versus dimension changes in visual search, as revealed by EEG and fMRI

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