Superior Mesenteric Vein Thrombosis Associated with Hormonal Contraceptive Use

Abstract

A 44-year-old woman was admitted with a 7-day history of lower abdominal pain and nausea. Physical examination demonstrated tenderness in the lower abdomen without signs of peritonitis. There were no specific findings in the laboratory evaluation. She had a history of dysmenorrhea for 15 years and was taking a combined hormonal contraceptive containing 0.02 mg ethinyl estradiol and 3 mg drospirenone for 19 months. Contrast-enhanced computed tomography showed superior mesenteric vein thrombosis (SMVT). Systemic anticoagulant infusion was immediately administered and the symptoms disappeared within 2 days. The thrombus disappeared after 3 months. This case report suggests that early diagnosis of SMVT and immediate systemic anticoagulant therapy may reduce the rate of intestinal infarction.

Venous acute disturbance of mesenteric circulation: diagnosis and treatment

“…Системными причинами заболевания могут быть различные тромбофилические состояния и коагулопатии: дефицит протеинов S и C, генетические дефекты протромбина, лейденовская мутация, дефицит антитромбина III, гипергомоцистеинемия, мутация G20210 протромбина и мутация JAK2 V617F, а также различные системные предрасполагающие состояния (сепсис, беременность, использование оральных контрацептивов, миелопролиферативные заболевания) [13,20,28,34,40,41,70,84].…”