Superior hydrolytic DNA cleavage by a dinuclear copper(II) N4S4-donor complex compared with a mononuclear N2S2-donor close analogue

DNA hydrolysis promoted by di- and multi-nuclear metal complexes

“…Plasmid DNA cleavage promoted by the dinuclear copper complex Cu II 2 (N 4 S 4 ) (N 4 S 4 : 1,2,4,5-tetrakis(1 -amino-3 -thiobutyl)benzene) is significantly greater than that by its mononuclear analogues, which is essentially inactive [64]. An apparent rate constant of 3.3 × 10 −5 s −1 was reported at pH 7.8 and 37 • C, when concentrations of this complex and of plasmid DNA were 75 M and 0.12 mg/ml, respectively.…”

A new family of pyrazolyl-based anionic bidentate ligands and crystal structure of bis(N-phenyl-2-pyrazolyl-1-carboximidothioato)copper(II)

“…The structure of 4 is also very similar to that of the anionic cis-CuN 2 S 2 complex, [Cu(SCH 2 CH(CO 2 Me) NHCH 2 ) 2 ] À , which has been introduced as a synthetic model for the copper proteins such as poplar plastocyanin [25]. Even if, the bonding parameters about Cu atom in 4 are somewhat different from those of the mentioned metalloproteins, they match better than the previously reported complexes [25][26][27][28].…”

Phosphatase models: Synthesis, structure and catalytic activity of zinc complexes derived from a phenolic Mannich-base ligand

“…The above postulated mechanistic pathway is reasonably consistent with, and can be used to systematically interpret, the experimental observations reached in our case. The dinuclear compounds are expectedly more catalytically active than their mononuclear analogues [43][44][45][46][47]24,48], although the former provide effectively mononuclear species in solution. This is primarily due to the fact that the total concentration of catalytically active species is twice in case of dinuclear complexes independent of the halide ion.…”