Superior hybrid hydrogels of polyacrylamide enhanced by bacterial cellulose nanofiber clusters

Yuan, Ningxiao; Xu, Lu; Zhang, Lu; Ye, Haowen; Zhao, Jianhao; Liu, Zhong; Rong, Jian

doi:10.1016/j.msec.2016.04.074

Cited by 97 publications

(40 citation statements)

References 53 publications

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“…The volume of the GelMA/PAM biohybrid hydrogel remained relatively stable after 50 h, indicating "nonswellable" properties that are important when applied as cartilage replacement materials. 31 The calculated equilibrium weight ratio showed that the weight-swelling ratio of the GelMA/PAM biohybrid hydrogel was similar as that of the GelMA hydrogel and significantly lower than that of the PAM hydrogel. There are two explanations for the low swelling ratio of the GelMA-based hydrogel.…”

Section: Swelling Ratiomentioning

confidence: 90%

Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

Han

et al. 2017

J. Mater. Chem. B

138

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Articular cartilage defect repair is challenging for clinics because it is avascular tissue lack of self-regenerative ability. Gelatin-based hydrogels are widely used in the field of tissue engineering because of their good biodegradability, excellent biocompatibility, and cell/tissue affinity. However, gelatin-based hydrogels exhibit poor thermal stability and low mechanical strength, which limits their applications in cartilage repair. In this study, methacrylic anhydride (MA) was employed to modify gelatin to obtain photo-crosslinkable methacrylated gelatin (GelMA). The GelMA-based natural-synthetic polymer biohybrid hydrogel was prepared by co-polymerizing acrylamide (AM) and GelMA under ultraviolet radiation in the presence of a photo-initiator. The GelMA/PAM biohybrid hydrogel simultaneously possessed the advantages of both PAM hydrogels and GelMA hydrogels. The GelMA block provided specific biological functions for cell adhesion and proliferation, while the flexible PAM chains reinforced the brittle gelatin network and sustain load during deformation. Compared with pure PAM hydrogel and GelMA, the GelMA/PAM biohybrid hydrogels showed enhanced compression strength (0.38 MPa) and improved elasticity (storage modulus of 1000 Pa). The GelMA/PAM biohybrid hydrogel showed a favorable degradation rate and sustained protein release. In vitro cell culture showed that the chondrocytes remained viable and proliferated on the biohybrid hydrogel, demonstrating that the biohybrid hydrogels had good cell adhesion and excellent biocompatibility. In a rabbit knee cartilage defect model, we evaluated the cartilage repair ability of the biohybrid hydrogel in vivo. In summary, this study demonstrated that hybridization of synthetic polymers considerably improves the performance and expands the application of the gelatin-based hydrogels. The biohybrid

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Section: Swelling Ratiomentioning

confidence: 90%

Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

Han

et al. 2017

J. Mater. Chem. B

138

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“…The most outstanding properties of BC is compatibility, high water holding capacity, purity, moldability, and biodegradability which has been used for many purposes especially for medical and biomedical fields [1][2][3][4][5][6][7]. Accordingly, it has been used in modern wound dressing, artificial blood vessels, drug delivery system, artificial skin, and tissue engineering scaffold [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Preventing the collapse of 3D bacterial cellulose network via citric acid

et al. 2018

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Bacterial cellulose (BC) is a three-dimensional interconnected network of biosynthesized nanofibers. Its rehydration potential would be reduced significantly after its first drying, as a result of entanglement and jamming of cellulose polymer chains. Consequently, its versatility would be also reduced to some limited applications in which repeated water absorbance potential is not of great importance. This study aims to prevent the drawback of carboxylic bridging/cross-linking between cellulose polymer chains. Ten-day-cultured BC pellicles were immersed in various citric acid solutions (as bridging agent) and cured at 160 °C for 5 min. The formation of bridges was confirmed using attenuated total reflection-fourier transform infrared spectroscopy. Scanning electron microscope images showed that there is a different porosity bridged/cross-linked BC specimens (XBC). According to Brunauer-Emmett-Teller analysis, the surface area of XBC (20 w/v % with catalyst) got 87.5 times larger than that of the unbridged/pristine BC (PBC). X-ray diffraction patterns showed no change of crystallinity of XBC in comparison with PBS. The thickness and wettability of XBC samples were 137 and 3.27 times more than PBC samples orderly. Furthermore, the water swelling rate increased significantly for XBC in comparison with PBC. Meanwhile, treated samples had lower elongation and strength than normal BC. The conclusion is that XBC could conserve its repeated absorbency potential after the presented process.

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“…Their water adsorbing ability is due to the hydrophilic groups present in their structure. The organic pollutants get adsorb into hydrogels as the ionic groups of organic pollutants form physical or chemical interaction with hydrophilic groups of hydrogels [5][6][7][8][9][10]. The addition of reinforcing agents and using crosslinkers during their synthesis helps in increasing the mechanical strength of the hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of a nanocomposite hydrogel for combined photocatalytic degradation of a mixture of malachite green and fast green dye

Sharma

ALOthman

Kumar

et al. 2017

Nanotechnol. Environ. Eng.

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In this study, starch/poly(alginic acid-cl-acrylamide)/Fe/Zn nanocomposite hydrogel (ST/PL(AA-clAAm)/Fe/Zn NCHG) was synthesized by polymerization/ co-precipitation method. This nanocomposite hydrogel was prepared with the notion to remove the mixture of organic pollutants from the water system. Mixture of malachite green and fast green dye was used to check the photocatalytic degradation ability of the prepared nanocomposite hydrogel. ST/PL(AA-cl-AAm)/Fe/Zn NCHG was characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy and Fourier transform infrared. The degradation of the two dyes followed the pseudo-first-order kinetics. The results showed that by using the prepared nanocomposite hydrogel, 91% of malachite green and 82% of fast green dye, respectively, were degraded within 5 h of their contact.

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Superior hybrid hydrogels of polyacrylamide enhanced by bacterial cellulose nanofiber clusters

Cited by 97 publications

References 53 publications

Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

Biohybrid methacrylated gelatin/polyacrylamide hydrogels for cartilage repair

Preventing the collapse of 3D bacterial cellulose network via citric acid

Fabrication and characterization of a nanocomposite hydrogel for combined photocatalytic degradation of a mixture of malachite green and fast green dye

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