Superior antitumor effect of self-assembly supramolecular paclitaxel nanoparticles

Yu, Na; Li, Jun; Zhang, Yuan; Li, Xin; Xu, Huae

doi:10.1039/d0ra01117g

Cited by 7 publications

(8 citation statements)

References 38 publications

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“…MDR-related HCT 15 cells overexpressing p-gp were incubated in a cell culture medium containing RPMI-1640 medium, 10% FBS, and 1% AA at 37 °C in a humidified 5% CO 2 atmosphere. The anticancer efficacy of PTX itself and that of PTX@TNPs with different drug loads were evaluated using the CCK-8 assay kit as previously described [ 29 , 30 ]. HCT 15 cells were seeded onto 96-well plates at a density of 10,000 viable cells per well and cultured overnight at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

High Solubilization and Controlled Release of Paclitaxel Using Thermosponge Nanoparticles for Effective Cancer Therapy

Lee

Sung

et al. 2021

Pharmaceutics

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Cancer, which is a leading cause of death, contributes significantly to reducing life expectancy worldwide. Even though paclitaxel (PTX) is known as one of the main anticancer drugs, it has several limitations, including low solubility in aqueous solutions, a limited dosage range, an insufficient release amount, and patient resistance. To overcome these limitations, we suggest the development of PTX-loaded thermosponge nanoparticles (PTX@TNP), which result in improved anticancer effects, via a simple nanoprecipitation method, which allows the preparation of PTX@TNPs with hydrophobic interactions without any chemical conjugation. Further, to improve the drug content and yield of the prepared complex, the co-organic solvent ratio was optimized. Thus, it was observed that the drug release rate increased as the drug capacity of PTX@TNPs increased. Furthermore, increasing PTX loading led to considerable anticancer activity against multidrug resistance (MDR)-related colorectal cancer cells (HCT 15), implying a synergistic anticancer effect. These results suggest that the solubilization of high drug amounts and the controlled release of poorly water-soluble PTX using TNPs could significantly improve its anticancer therapy, particularly in the treatment of MDR-p-glycoprotein-overexpressing cancers.

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Section: Methodsmentioning

confidence: 99%

High Solubilization and Controlled Release of Paclitaxel Using Thermosponge Nanoparticles for Effective Cancer Therapy

Lee

Sung

et al. 2021

Pharmaceutics

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“…e particles were observed by transmission electron microscope as spherical objects of uniform size, and the diameter size was consistent with the particle size detection results. Experimentally, the drug content of paclitaxel nanoparticles was 19.58%, and the embedding rate was 93.25% [19].…”

Section: Analysis Of Paclitaxel Nanoparticles In Thementioning

confidence: 99%

Tennis Rehabilitation Training-Assisted Paclitaxel Nanoparticles in Treatment of Lung Tumor

Yang

2020

Journal of Chemistry

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Paclitaxel nanoparticles are a compound with unique anticancer effects. Its mechanism of action is to prevent tumor rupture by stabilizing tumor proteins, while preventing cell division, leading to cell death, thereby inhibiting the spread of lung tumors. This article aims to study the treatment of lung tumors with paclitaxel nanoparticles assisted by tennis rehabilitation training. In this paper, paclitaxel nanoparticles were prepared by a solvent displacement method, and their particle size and morphology were measured. The TA2 series of experimental rats were selected to establish animal lung tumor models, and they were randomly divided into 5 groups: local injection of saline, porphyrin, and low-, medium-, and high-dose paclitaxel nanoparticles for treatment. The experimental results in this paper show that the average particle size of the paclitaxel nanoparticles prepared in the experiment is about 153,54 nm. Each treatment group inhibited tumor development to varying degrees. Among them, the inhibitory volume rate of paclitaxel nanoparticles in the middle- and high-dose groups was significantly higher than that in the paclitaxel treatment group, indicating that paclitaxel nanoparticles can release drugs slowly.

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“…In vitro studies demonstrated that PTX loaded in PEG-based micelles exhibited enhanced tumor inhibitory comparing to free PTX alone (with IC 50 values of PTX-NPs and free PTX were 123.9 × 10 −9 and 204.6 × 10 −9 m, respectively). [163] Mutlu-Agardan et al used 3,3′-dithiodipropionic acid to introduce disulfide bond between PTX and PEG 2000 , introducing glutathione-responsive cleavage (Figure 7a). [164] On such reduction-sensitive drug delivery vehicle, Shi et al further introduced RGD peptide which targets 𝛼 v 𝛽3 integrin that is highly expressed by cancer cells.…”

Section: Poly(ethylene Glycol)mentioning

confidence: 99%

Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

Wang

et al. 2023

Advanced Therapeutics

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Paclitaxel (PTX) is a broad-spectrum alkaloid anticancer drug with high therapeutic efficacy. However, PTX has a very low water solubility and its metabolism demonstrates nonlinear pharmacokinetic characteristics, resulting in systemic adverse reactions in clinical applications. Many endeavors are devoted to develop new PTX preparations in response to these obstacles, and some are used in clinical phase of cancer treatment. In particular, highly specific medical intervention at nanoscale is an emerging research field focusing on nanoapproaches to solve clinical problems. In a perspective of nanomedicine, the recent covalent and noncovalent approaches toward PTX formulation on various substrates, as well as their advantages and disadvantages during preclinical researches and clinical applications are herein summarized. It is anticipated that nanotechnology-based drug delivery systems can further enhance therapeutic efficiencies of PTX, by reducing systemic side effects and alleviating severely negative effects on patients.

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Superior antitumor effect of self-assembly supramolecular paclitaxel nanoparticles

Abstract: Carrier-free paclitaxel nanoparticles with higher drug loading efficiency, less non-specific toxicity and more stable and durable antitumor effect of Ptx.

Cited by 7 publications

References 38 publications

High Solubilization and Controlled Release of Paclitaxel Using Thermosponge Nanoparticles for Effective Cancer Therapy

High Solubilization and Controlled Release of Paclitaxel Using Thermosponge Nanoparticles for Effective Cancer Therapy

Tennis Rehabilitation Training-Assisted Paclitaxel Nanoparticles in Treatment of Lung Tumor

Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

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