Superior anti‐emetic efficacy of granisetron–dexamethasone combination in children undergoing middle ear surgery

Abstract

The prophylactic granisetron-dexamethasone combination was more effective than granisetron alone in the prevention of post-operative emesis during the first 24 h after anaesthesia in children undergoing middle ear surgery.

Comparison of antiemetic activity of palonosetron with granisetron in postoperative nausea and vomiting after laparoscopic gynaecological surgeries

“…The results were found to be not significant and comparable in all aspects. The incidence of vomiting after administration of rescue antiemetic in our study was very low compared to that of studies done by Katsuya et al and Gombar S et al 13,23 Our results were also comparable with the study performed by Bhattacharjee et al 18 They did a comparative study between palonosetron and granisetron to prevent postoperative nausea and vomiting after laparoscopic cholecystectomy and inferred that the incidence of a complete response (no postoperative nausea and vomiting, no rescue medication) during 0-3 hrs in the postoperative period was 36.6% with granisetron and 90% with palonosetron, the incidence during 3 -24 hrs postoperatively was 83.3% with granisetron and 90% with palonosetron and during 24 -48 hrs, the incidence was 66.6% and 90% respectively (p<0.05). The incidence of adverse effects were statistically insignificant between these groups concluding that Prophylactic therapy with palonosetron is more effective than granisetron for long Adverse effects observed in this study were not clinically serious and did not differ in incidence between the groups.…”

Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial

“…The number of patients required for the study was calculated on assumption that addition of dexamethasone to granisetron will result in decrease in the incidence of PONV from 20% to 3.3% [ 5 ]. For α = 0.05 and power (1 − β ) = 0.8, based on these assumptions, 59 children in each group were required.…”

“…Granisetron, a selective 5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonist, is a potent and long acting antiemetic [ 4 ]. Review of literature showed that optimal dose of granisetron for prevention of PONV was 40 mcg/kg [ 5 ] while dexamethasone has been used in 50 mcg/kg to 1 mg/kg for PONV prophylaxis [ 6 , 7 ].…”

“…It has been observed that combination of granisetron 40 mcg/kg and dexamethasone 150 mcg/kg is more effective than granisetron 40 mcg/kg alone in children undergoing various types of surgeries [ 5 , 8 ]. However, there is no clinical trial to evaluate the efficacy of this combination in pediatric strabismus surgery alone.…”

Dexamethasone for the prevention of postoperative nausea and vomiting in children undergoing non-cardiac surgery: a systematic review and meta-analysis

“…Three studies [14,20,23] compared dexamethasone plus a 5-HT3 receptor antagonist with 5-HT3 receptor antagonist alone for the prevention of POV. Analysis showed that dexamethasone combined with a 5-HT3 receptor antagonist was significantly better than the 5-HT3 receptor antagonist alone in preventing POV (RR 0.25, 95% CI 0.12-0.52, P<0.01; I 2 =0%; Figure 5).…”