Superior and Inferior Ophthalmic Vein Thrombosis in the Setting of Lung Cancer

Habib, Nawal; Lessard, Kimberly Kochersperger

doi:10.1155/2018/6025274

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…The SOVT in SLE without antiphospholipid syndrome is attributed to inflammation and SOVT in SLE with the antiphospholipid syndrome is attributed to hypercoagulation [[13], [14], [15]]. There is an association between the systemic malignancies (leukemia, lymphoma, multiple myeloma, lung cancer and amyloidosis) and the SOVT [[3], [4], [5], [6],16,17]. We also detected a case of breast cancer with SOVT although the patient was complicated by cellulitis.…”

Section: Discussionmentioning

confidence: 99%

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Sotoudeh

Shafaat

Aboueldahab

et al. 2019

European Journal of Radiology Open

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Superior ophthalmic vein thrombosis (SOVT) is an extremely rare condition. Few studies have been published about clinical aspects of this condition. In this study, we have studied the symptoms, underlying etiologies, treatment, pathogenesis and complication of the SOVT and we tried to classify it based on the etiology, treatment, and prognosis. Methods: We reviewed the patients' data from a tertiary academic referral center. Each patient with SOVT was then reviewed for symptoms associated with SOVT, underlying etiology, treatment protocol, treatment response, complications, possible pathogens, and final outcome. Results: Twenty-four cases of SOVT were included in this study. Overall, 13 cases were diagnosed as right-sided SOVT, out of which, eight had simultaneous right-sided cavernous sinus thrombosis (CST). Eighteen cases were diagnosed to have left-sided SOVT, out of which, 11 had simultaneous left-sided CST. Conclusions: The SOVT can be secondary to different mechanisms. The SOVT secondary to trauma, recent surgery and coagulopathy are mostly non-aggressive, and can be managed by conservative therapy and anticoagulation. The SOVT in patients with orbital cellulitis, history of active sinusitis or paranasal sinus surgery are aggressive presenting with acute orbital swelling, abscess and visual loss. This type of SOVT can be complicated by extension to the cavernous sinus and intracranial structures. These patients require urgent antibiotics therapy and sinus surgery. The most severe type of SOVT is caused by mucormycosis which may also extend intracranially resulting in stroke and is often life-threatening.

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Section: Discussionmentioning

confidence: 99%

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Sotoudeh

Shafaat

Aboueldahab

et al. 2019

European Journal of Radiology Open

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“…Además de las enfermedades orbitales y del seno cavernoso, hay factores de riesgo sistémicos, como estados de hipercoagulabilidad o amiloidosis, así como enfermedades inflamatorias y malignas que pueden predisponer a la trombosis de la vena oftálmica superior 12,[18][19][20][21] . Otros elementos, como los que componen la tríada de Virchow (estasis vascular, daño endotelial e hipercoagulabilidad), desempeñan un papel importante en la fisiopatología 19 .…”

Section: Discussionunclassified

Causas infrecuentes de proptosis aguda dolorosa. Reporte de casos

Maimó-Gallego¹,

Riesgo²,

Bory-Vargas³

et al. 2023

RMO

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Introducción: Los trastornos del drenaje venoso orbitario incluyen proptosis de inicio brusco, edema de los párpados, dilatación de los vasos venosos epiesclerales, hipertensión ocular y oftalmoplejía. La resonancia magnética es el mejor método para identificar la causa. Casos clínicos: Se reportan dos casos inusuales, en pacientes de 54 y 56 años de edad. Se presentaron con proptosis dolorosa aguda. Uno de ellos desarrolló edema de párpados, quemosis, dilatación y tortuosidad de los vasos venosos epiesclerales, así como hipertensión ocular. En este caso se detectó una trombosis de la vena oftálmica superior izquierda. El segundo paciente experimentó síntomas clínicos similares, pero se diagnosticó una metástasis en el seno cavernoso izquierdo. Estas afecciones son diferentes variantes de trastornos del drenaje venoso orbitario con un comportamiento clínico similar, aunque de diferentes causas. Estos diagnósticos deben considerarse en todo paciente con proptosis aguda dolorosa. Se han reportado pocos casos en la literatura.

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“…Functional resistance to APC-R assays and genetic testing using DNA-based techniques can both be used to identify the FVL mutation and differentiate between heterozygotes and homozygotes. In the Caucasian community, the FVL mutation was discovered to be the most prevalent inherited thrombophilic condition, accounting for up to 37% of venous thrombosis cases [ 17 ]. In our case, ophthalmic vein thrombosis may be a consequence of the synergism between the two hematological abnormalities.…”

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confidence: 99%

“…It is important to rule out an infectious cause (that would require antibiotic treatment). In aseptic cases, anticoagulant treatment can be initiated, but only after an adequate assessment of the associated bleeding risks [ 17 ]. Additionally, treatment with corticosteroids can be useful in reducing orbital inflammation and congestion [ 22 ].…”

mentioning

confidence: 99%

Ophthalmic Vein Thrombosis Associated with Factor V Leiden and MTHFR Mutations

et al. 2023

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Superior ophthalmic vein thrombosis (SOVT) is a rare clinical entity that may be associated with hypercoagulability status. We present a case of a 77-year-old woman who presented to the emergency department complaining of eye ptosis, chemosis and conjunctival congestion in the right eye (RE). The ophthalmological examination revealed best-corrected visual acuity (BCVA) was 0.5 for the right eye (RE) 0.5 and 0.06 for the left eye (LE). Intraocular pressure (IOP) was 25 mmHg in RE and 14 mmHg in LE. Non-contrast computed tomography (CT) of the brain and orbits revealed a hyperreflectivity at the level of the right ophthalmic vein and inferior rectus muscle hypertrophy. An extensive hypercoagulable panel was completed and we found a positive result for Factor V Leiden (heterozygous mutation) and methyl-enetetrahydrofolate reductase (MTHFR-C677T homozygous mutations). Systemic steroidal anti-inflammatory and anticoagulant treatments were started immediately. Gradual resolution of symptoms was noted during the hospitalization, and BCVA in her RE was established at 0.7 at the 10-week follow-up.

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Superior and Inferior Ophthalmic Vein Thrombosis in the Setting of Lung Cancer

Cited by 5 publications

References 4 publications

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Superior ophthalmic vein thrombosis: What radiologist and clinician must know?

Causas infrecuentes de proptosis aguda dolorosa. Reporte de casos

Ophthalmic Vein Thrombosis Associated with Factor V Leiden and MTHFR Mutations

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