2023
DOI: 10.1371/journal.pbio.3001941
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Superinfection exclusion creates spatially distinct influenza virus populations

Abstract: Interactions between viruses during coinfections can influence viral fitness and population diversity, as seen in the generation of reassortant pandemic influenza A virus (IAV) strains. However, opportunities for interactions between closely related viruses are limited by a process known as superinfection exclusion (SIE), which blocks coinfection shortly after primary infection. Using IAVs, we asked whether SIE, an effect which occurs at the level of individual cells, could limit interactions between populatio… Show more

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Cited by 20 publications
(15 citation statements)
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“…The cell remains open to secondary infection for a period of hours but then adopts an exclusionary state in which newly arriving viruses are not able to initiate sustained replication [3,4]. Sims and colleagues [2] show that this temporal effect gives rise to strong spatial patterning (Fig 1). Their data support a model in which only viruses that are nearby in space-because they are progeny of the same infected cell, for example-can readily coinfect within the time window that precedes exclusion.…”
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confidence: 99%
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“…The cell remains open to secondary infection for a period of hours but then adopts an exclusionary state in which newly arriving viruses are not able to initiate sustained replication [3,4]. Sims and colleagues [2] show that this temporal effect gives rise to strong spatial patterning (Fig 1). Their data support a model in which only viruses that are nearby in space-because they are progeny of the same infected cell, for example-can readily coinfect within the time window that precedes exclusion.…”
mentioning
confidence: 99%
“…Similarly, in swine, viral variants generated through reassortment formed spatially distinct subpopulations, typically with only a few novel genotypes detected at each site. In light of the findings of Sims and colleagues [ 2 ], both the low diversity within each site and the observed lack of mixing between them can be explained by superinfection exclusion: Only the first viruses to become established at a site are efficiently propagated, with any subsequently arriving viruses unable to penetrate.…”
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confidence: 99%
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