The market demand for multifunctional cotton fabric is increasing. However, the key of developing cotton fabric with multiple functions is how to solve the problem of functional combination. In this study, silver@titanium dioxide Janus nanoparticles (Ag@TiO 2 Janus nanoparticles) were synthesized by Pickering emulsion polymerization and nished on the epoxy modi ed cotton fabric (Ag@TiO 2 Janus/Ecotton fabric). The Ag@TiO 2 Janus nanoparticles had asymmetric Janus structure, that one side being silane with hydrophilic amino group was covalently bonded with the epoxy group on the cotton fabric bers and the other side being silane with hydrophobic long-chain alkane was faced the environment, which was to endow the cotton fabric durably superhydrophobic, UV resistance, and antibacterial. Characterization by SEM, XRD, EDS, EDS, FT-IR and TG veri ed the nishing of the cotton fabric with Ag@TiO 2 Janus nanoparticles. Ag@TiO 2 Janus/E-cotton fabric had a water contact angle of 160, after 50 wear cycles, the contact angle at the damaged part could still reach 152. Compared with raw cotton fabric, the antibacterial rate of Ag@TiO 2 Janus/E-cotton fabric to Escherichia coli (E. coli) and Streptococcus Urealyticus (S. aureus) is more than 95%. After 8 ultrasonic washing cycles, the antibacterial rate still maintained more than 80%. The UV protection performance of the nished cotton fabric was improved by 82.3%.Authors contributions Dangge Gao conceived the concept, supervised the project and provided nancial support and thoughts of manuscript. Fangxing Wang performed the experiment, prepared the samples and did the manuscript and analysis. Zhouyang Zhao performed the experiment and provided thought. Lyu Bin provided manuscript retouching and fund support. Jianzhong Ma provided the thought, manuscript retouching and fund.