Superhydrophilic versus normal polydopamine coating: A superior and robust platform for synergistic antibacterial and antithrombotic properties

Li, Linhua; Yang, Li; Liao, Yanbiao; Yu, Hongchi; Liang, Zhen; Zhang, Bo; Lan, Xiaorong; Luo, Rifang; Wang, Yunbing

doi:10.1016/j.cej.2020.126196

Cited by 85 publications

(52 citation statements)

References 51 publications

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“…[194] More importantly, the wet-adhesive and charged PDA has good affinity to protein adhesion which might be a critical defect for blood-contacting process. [195] Direct exposure of these PDA-based nanomaterials with high specific surface area to blood would result in a fast adsorption of proteins onto the surface, formation of a "protein corona" within minutes, [196] as well as the increment of the risk of thrombus formation. [197] In contrast, the possible risks of negative effects within cells or tissues can be avoided in the in vitro applications.…”

Section: Discussionmentioning

confidence: 99%

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

Xie

Tang

Xing

et al. 2021

Adv Healthcare Materials

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The translation of mussel‐inspired wet adhesion to biomedical engineering fields have catalyzed the emergence of polydopamine (PDA)‐based nanomaterials with privileged features and properties of conducting multiple interfacial interactions. Recent concerns and progress on the understanding of PDA's hierarchical structure and progressive assembly are inspiring approaches toward novel nanostructures with property and function advantages over simple nanoparticle architectures. Major breakthroughs in this field demonstrated the essential role of π–π stacking and π‐cation interactions in the rational intervention of PDA self‐assembly. In this review, the recently emerging concepts in the preparation and application of PDA nanomaterials, including 3D mesostructures, low‐dimensional nanostructures, micelle/nanoemulsion based nanoclusters, as well as other multicomponent nanohybrids by the segregation and organization of PDA building blocks on nanoscale interfaces are outlined. The contribution of π‐electron interactions on the interfacial loading/release of π electron‐rich molecules (nucleic acids, drugs, photosensitizers) and the exogenous coupling of optical energy, as well as the impact of wet‐adhesion interactions on the nano‐bio interface interplay, are highlighted by discussing the structure‐property relationships in their featured applications including fluorescent biosensing, gene therapy, drug delivery, phototherapy, combined therapy, etc. The limitations of current explorations, and future research directions are also discussed.

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Section: Discussionmentioning

confidence: 99%

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

Xie

Tang

Xing

et al. 2021

Adv Healthcare Materials

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“…Even so, these are commonly used in conjunction with oral or injectable coagulants prophylactically to increase their effectiveness and reduce the risk of bleeding and clot formation at the catheter site [17]. Another recent modification of catheters involves superhydrophilicity of their surface, which prevents RBC adhesion [18]. As therapeutic measures, other mechanisms have been developed, such as filters designed to collect the thrombi and experimental drugs injected into the bloodstream that have the capacity to undo the thrombi [19].…”

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Proanthocyanidins from Blueberries’ Surface Coating Prevents Red Blood Cell Agglutination on Urinary Silicon-Based Catheters

Orozco-Fernández

Gómez-Solano

Calderón³

et al. 2022

Coatings

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Thrombosis can cause the occlusion of implantable medical devices, leading to the rejection of the device and subsequent mortality. Thrombosis is primarily induced by red blood aggregation and coagulation. The administration of anticoagulant drugs is generally used as a treatment to avoid these processes. Adverse effects such as bleeding in the event of an anticoagulant overdose, osteoporosis associated with prolonged use, hypersensitivity, and hives have been reported. New strategies such as biomolecule surface functionalization have recently been studied to overcome these problems. In this study, we report a novel coating composed of polydopamine (PDA) and proanthocyanidins (PACs) from blueberry extract to avoid red blood aggregation in short-term use medical devices such as silicone catheters. We showed that PDA formed stable films on silicone surfaces and PACs could be immobilized on PDA layers using laccase as a catalyst. The PDA–PACs films decreased surface hydrophilicity, increased surface roughness, and decreased plasma protein adsorption. The films were stable in phosphate buffer saline (PBS) and cell culture media. Furthermore, red blood cell adsorption and aggregation decreased. These effects are attributed to changes in the membrane fluidity that influences adhesion, the steric hindrance of the layers, and the low adsorption of plasma proteins on the PAC layer.

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“…In addition, several antibacterial therapies using biopolymeric, polymeric scaffolds (Lemnaru (Popa) et al., 2020 ; Zarayneh et al., 2018 ; Lu et al., 2018 ) and other biological antibacterial strategies (Sunderland et al., 2017 ; Jasim et al., 2018 ; Shahraki & Mirsaeidi, 2021 ) have been developed. Compared with the reported mediums for the fabrication of antibacterial system, polydopamine (pDA), which can self-polymerize on the variable solid surface under suitable conditions (Weng et al., 2015 ; Ryu et al., 2018 ), has emerged as an effective tool for biomolecular immobilization (Bai et al., 2020 ; Fu et al., 2021 ), metal deposition (Li et al., 2020 ), and metal oxide entrapment (Xian et al., 2020 ) for biomedical applications including disinfection due to integrated activity. However, most of the applications of pDA coating are based on the application of residual –NH 2 or –OH for the covalent conjugate (Kwon & Bettinger, 2018 ; Qi et al., 2019 ; Jin et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

et al. 2021

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Existing biologically inert or unmodified implants to treat infectious bone defects or osteomyelitis still cannot effectively solve bacterial infection and osseointegration. In this work, a simple co-deposition strategy was developed to modify porous polyetheretherketone (PEEK) with improved antibacterial activity and controllable immunoregulatory ability. After PEEK was treated by H 2 SO 4 to obtain porous PEEK (SPEEK), the self-polymerization of dopamine was operated on SPEEK in the solution of dopamine and gentamicin sulfate (GS) to prepare polydopamine (pDA) and GS layer-modified SPEEK (labeled as SPEEK–pDA–GS). The morphology, surface property, and molecular structure of SPEEK–pDA–GS were investigated. Besides the antibacterial property of SPEEK–pDA–GS ascribed to the successful immobilization of GS, SPEEK–pDA–GS exhibited promoted osseointegration through the results of mineralization, alkaline phosphatase (ALP) levels and osteogenic gene expression. Furthermore, the evaluation of the cell proliferation suggested that SPEEK–pDA–GS possessed the biocompatibility and the immunoregulatory ability that induced macrophages to anti-inflammatory M2 phenotype. Using rat as model, in vivo results containing X-ray, μ-CT, immunohistochemistry, and pathological analysis showed the excellent healing effect of SPEEK–pDA–GS on bone defect with infection with biological safety. This work illustrates a new insight into the simple and effective modification of PEEK and other implants with antibacterial, immunoregulatory, and osseointegration abilities for clinical requirement.

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Superhydrophilic versus normal polydopamine coating: A superior and robust platform for synergistic antibacterial and antithrombotic properties

Cited by 85 publications

References 51 publications

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

Bio-Inspired Proanthocyanidins from Blueberries’ Surface Coating Prevents Red Blood Cell Agglutination on Urinary Silicon-Based Catheters

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

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