Superficial X-rays Versus Surface Brachytherapy for Non-Melanoma Skin Cancer: A Matched Pair Analysis

Abstract

using pre-operative radiation therapy. Patients had to have an operable tumor and no evidence of distant metastases. The majority of the tumors were fairly extensive and displacing abdominal organs. All patients were treated with megavoltage radiation with IMRT delivery. A minimum dose of 45 Gy was delivered to full volume with a margin to the PTV. An SIB was delivered to the GTV or the high dose areas to a dose of 55 GY all in 25 Daily Fractions. Surgery followed 4-6 weeks later. Results: During the period of 2011 to 2014, 23 patient s have been treated. The use of IMRT has facilitated dose delivery and escalation in a safe manner. The patterns of toxicity including bowel symptoms and delayed healing have been compared with historical controls. None of our patient has developed any significant acute toxicity necessitating stopping radiation therapy. No severe late effects have been reported. Despite the large volume treatment surgical resections have been successful in all patients. Follow-up is ranging from 6 months to 4 years. Detailed toxicity analysis will be presented at the meeting. Conclusion: Dose escalation and dose delivery to a large abdominal volume are safe and feasible in RP Sarcomas with the use of IMRT. Acute and subacute side effects are limited and much less than historical controls. It remains to be seen if that will translate into long term improvement in survival.