Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features

Schilling, Kurt G.; Archer, Derek B.; Rheault, François; Lyu, Ilwoo; Huo, Yuankai; Cai, Leon Y.; Bunge, Silvia A.; Weiner, Kevin S.; Gore, John C.; Anderson, Adam W.; Landman, Bennett A.

doi:10.1007/s00429-023-02642-x

Cited by 11 publications

(5 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous investigations have discerned differential growth patterns in gray and white matter during murine development, revealing tension in white matter and compression in gray matter, culminating in the generation of significant residual solid stress ( 26 ). Specifically, white matter volume reaches its peak at adolescence, and plateau during adulthood ( 40 ), which is similar to our findings that the residual solid stress increases during development and remains high through adulthood. Thus, the increasing white matter volume could be a potential determinant of residual solid stresses.…”

Section: Resultssupporting

confidence: 91%

Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke

Zheng,

Banerji,

LeBourdais

et al. 2024

PNAS Nexus

View full text Add to dashboard Cite

Residual mechanical stresses, also known as solid stresses, emerge during rapid differential growth or remodeling of tissues, as observed in morphogenesis and tumor growth. While residual stresses typically dissipate in most healthy adult organs, as the growth rate decreases, high residual stresses have been reported in mature, healthy brains. However, the origins and consequences of residual mechanical stresses in the brain across health, aging, and disease remain poorly understood. Here, we utilized and validated a previously developed method to map residual mechanical stresses in the brains of mice across three age groups: 5–7 days, 8–12 weeks, and 22 months. We found that residual solid stress rapidly increases from 5–7 days to 8–12 weeks and remains high in mature 22 months mice brains. Three-dimensional mapping revealed unevenly distributed residual stresses from the anterior to posterior coronal brain sections. Since the brain is rich in negatively charged hyaluronic acid, we evaluated the contribution of charged extracellular matrix (ECM) constituents in maintaining solid stress levels. We found that lower ionic strength leads to elevated solid stresses, consistent with its unshielding effect and the subsequent expansion of charged ECM components. Lastly, we demonstrated that hemorrhagic stroke, accompanied by loss of cellular density, resulted in decreased residual stress in the murine brain. Our findings contribute to a better understanding of spatiotemporal alterations of residual solid stresses in healthy and diseased brains, a crucial step toward uncovering the biological and immunological consequences of this understudied mechanical phenotype in the brain.

show abstract

Section: Resultssupporting

confidence: 91%

Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke

Zheng,

Banerji,

LeBourdais

et al. 2024

PNAS Nexus

View full text Add to dashboard Cite

show abstract

“…Future work may also consider exploring alternative segmentations for comparing regional WM and GM volume changes, such as comparing cortical GM volume loss with growth of only the superficial WM volume that it encircles (Schilling et al, 2023 ). Doing so would make it possible to determine whether our observed changes in WM volume are primarily attributable to growth in superficial or deep WM, and to assess whether superficial WM thickening patterns mirror cortical thinning patterns.…”

Section: Discussionmentioning

confidence: 99%

Can gray matter loss in early adolescence be explained by white matter growth?

Chad,

Lebel

2024

Human Brain Mapping

View full text Add to dashboard Cite

A fundamental puzzle about brain development is why the volume of gray matter (GM) apparently declines as white matter (WM) grows when children enter adolescence. Since pruned synapses are too small to affect GM volume, a prevailing theory posits that an expanded distribution of myelin causes the inner edge of the GM to “whiten” while total brain volume remains steady, shifting the MRI‐measured WM:GM boundary closer to the brain's outer surface. This theory inherently predicts that GM volume loss is concurrent with WM volume growth across regions, within sexes and over time, although these predictions have yet to be explicitly tested. In this study, we test these predictions by mapping regional GM and WM volumetric changes in 2333 participants of the Adolescent Brain Cognitive Development study aged 9–14 years who each received three MRI scans 2 years apart. We show that average GM and WM volume changes follow distinct spatial, temporal, and sex‐specific patterns, indicating that GM volume loss is not balanced by WM volume growth, although cortical GM thinning is weakly correlated with WM growth in some regions. We conclude that myelin is not the main source of measured GM volume loss, and we propose alternative candidates.

show abstract

“…In this section, we discuss potential anatomical mechanisms contributing to the relationship between sulcal depth and behavior in two main ways. First, long-range white matter fibers have a gyral bias, while short-range white matter fibers have a sulcal bias in which some fibers project directly from the deepest points of a sulcus (Cottaar et al, 2021; Reveley et al, 2015; K. Schilling et al, 2018; K. G. Schilling et al, 2023; Van Essen et al, 2014). As such, recent work hypothesized a close link between sulcal depth and short-range white matter properties (Bodin et al, 2021; Pron et al, 2021; Voorhies et al, 2021; Willbrand, Ferrer, et al, 2023; Yao et al, 2022): deeper sulci would reflect even shorter short-range white matter fibers, which would result in faster communication between local, cortical regions and in turn, contribute to improved cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

Willbrand,

Tsai,

Gagnant

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Understanding the tripartite relationship among neuroanatomy, brain function, and cognition is of major interest across neurobiological subdisciplines. Recent advances in neuroimaging have uncovered neuroanatomical structures in evolutionarily-expanded portions of the brain that are related to individual differences in brain function and cognition. Here, we explored this relationship in lateral parietal cortex (LPC), a region crucial for many higher-level cognitive abilities. To do so, we manually defined 2176 individual sulci across 144 hemispheres. We identified four small and shallow indentations of the cerebral cortex (sulci) that were previously unidentified in the lateral parieto-occipital junction (LPOJ) and LPC. One of these sulci (ventral supralateral occipital sulcus, slocs-v) is present in nearly every hemisphere, and is morphologically, architecturally, and functionally dissociable from neighboring sulci. Implementing a data-driven, model-based approach relating sulcal depth to behavior identified different relationships of ventral and dorsal LPC/LPOJ sulcal networks contributing to the perception of spatial orientation. The model identified the slocs-v, further indicating the importance of this new neuroanatomical structure. Our findings build on classic neuroanatomical theories and identify new neuroanatomical targets for future “precision imaging” studies exploring the relationship among brain structure, brain function, and cognitive abilities at the level of the individual participant.

show abstract

Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features

Cited by 11 publications

References 87 publications

Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke

Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke

Can gray matter loss in early adolescence be explained by white matter growth?

Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

Contact Info

Product

Resources

About