Superficial thrombophlebitis

Salam, Hani

doi:10.53347/rid-24106

Cited by 1 publication

(2 citation statements)

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“…There are two main classifications of thrombophlebitis: superficial thrombophlebitis and deep vein thrombophlebitis. The former is frequently regarded as a less serious condition that may resolve on its own, while the latter presents a substantial danger of deep vein thrombosis and pulmonary embolism, which can result in increased morbidity and mortality 2 . Recent research highlights the fluctuating yet worrisome rates at which superficial phlebitis progresses to deeper, more perilous forms, with a significant proportion of patients developing pulmonary embolism 3 …”

Section: Introductionmentioning

confidence: 99%

“…The former is frequently regarded as a less serious condition that may resolve on its own, while the latter presents a substantial danger of deep vein thrombosis and pulmonary embolism, which can result in increased morbidity and mortality. 2 Recent research highlights the fluctuating yet worrisome rates at which superficial phlebitis progresses to deeper, more perilous forms, with a significant proportion of patients developing pulmonary embolism. 3 Irritating substances or high-concentration drugs administered intravenously are widely recognized as the primary etiological agents of thrombophlebitis.…”

Section: Introductionmentioning

confidence: 99%

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Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

Xiao,

Xie,

Liu

et al. 2023

International Wound Journal

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Thrombophlebitis is the inflammatory condition characterized by obstruction of one or more vessels, commonly in the legs, due to the formation of blood clots. It has been reported that traditional Chinese medicine, including Mailuoning injection, is advantageous for treating inflammatory and blood disorders. This research assessed the therapeutic efficacy of Mailuoning injection in the treatment of thrombophlebitis in rodents, as well as investigated its impact on fibrinolysis, inflammation, and coagulation. An experimental setup for thrombophlebitis was established in rodents via modified ligation technique. Five groups comprised the animals: sham operation group, model group, and three Mailuoning treatment groups (low, medium, and high dosages). The pain response, edema, coagulation parameters (PT, APTT, TT, FIB), serum inflammatory markers (IL‐6, TNF‐α, CRP), and expression levels of endothelial markers (ICAM‐1, VCAM‐1, NF‐κB) were evaluated. Blood flow and vascular function were further assessed by measuring hemorheological parameters and the concentrations of TXB2, ET, and 6‐k‐PGF1α. In contrast to the sham group, model group demonstrated statistically significant increases in endothelial expression levels, coagulation latencies, and inflammatory markers (p < 0.05). The administration of mailing, specifically at high and medium dosages, resulted in a substantial reduction in inflammatory markers, enhancement of coagulation parameters, suppression of ICAM‐1 and VCAM‐1 expression, and restoration of hemorheological measurements to baseline (p < 0.05). Significantly higher concentrations of 6‐k‐PGF1α and lower levels of TXB2 and ET were observed in high‐dose group, suggesting that pro‐ and anti‐thrombotic factors were restored to equilibrium. Utilization of Mailuoning injection in rat model of thrombophlebitis exhibited significant therapeutic impact. This effect was manifested through pain alleviation, diminished inflammation, enhanced blood viscosity and facilitation of fibrinolysis. The study indicated that Mailuoning injection may serve as a viable therapeutic option for thrombophlebitis, potentially aiding in the improvement of wound healing by virtue of its anti‐inflammatory and blood flow‐enhancing characteristics.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%