Superficial Soft Tissue Sarcomas of the Extremities and Trunk

Abstract

Patients with sSTS who are > or = 60 years of age or who have G3 tumors have a high risk of distant metastases. Patients with T2 tumors have an elevated risk for local recurrence. Certainly all patients with sSTS should be in a tight after-care program to allow early diagnosis of local recurrence or distant metastases. Age < 60 years, tumor grade G1/2, no positive regional lymph nodes (N0), and a R0 resection are significant prognostic factors for survival.

Outcomes of surgical treatment alone in patients with superficial soft tissue sarcoma regardless of size or grade

“…The recurrence rates presented here are comparable to those previously reported, however, these studies do not analyse outcomes according to type of treatment. In patients with superficial STS, rates for local recurrence range from 11–23% compared to 11.5% in the current study and metastatic recurrence range from 9–19% compared to 8.2% in the current study . The reported disease specific mortality rate in this study is 3.3% and is lower than rates previously reported for superficial STS which range from 7–18.2% .…”

“…In patients with superficial STS, rates for local recurrence range from 11–23% compared to 11.5% in the current study and metastatic recurrence range from 9–19% compared to 8.2% in the current study . The reported disease specific mortality rate in this study is 3.3% and is lower than rates previously reported for superficial STS which range from 7–18.2% . Therefore, in patients with superficial STS, surgical resection alone yields acceptable recurrence rates and radiation or chemotherapy can generally be reserved for those with recurrences, thereby saving the majority of patients the potential harmful effects of radiation including fibrosis, delayed wound healing, edema, and radiation related malignancies.…”

Managing soft tissue sarcomas in a developing country: are prognostic factors similar to those of developed world?

“…Soft-tissue sarcomas (STS) form a large and heterogeneous group of mesenchymal extraskeletal malignancies that account for < 1% of all malignant tumors in the general population [1]. ST can develop virtually anywhere in the body, however, most tumors originate in an extremity (59%), the trunk (19%), the retroperitoneum (15%), or the head and neck (9%) [2].…”

“…ST can develop virtually anywhere in the body, however, most tumors originate in an extremity (59%), the trunk (19%), the retroperitoneum (15%), or the head and neck (9%) [2]. Despite the variety of histologic subtypes, soft tissue sarcomas are grouped together at the clinical level because of parameters such as location, growth pattern and likelihood of recurrence, patient age, metastases, therapy, and prognosis [1]. …”

Weichgewebssarkome der oberen Extremität

“…Neben dem Ziel der onkologisch gerechten Tumorresektion steht bei der Therapie von Weichgewebssarkomen im Extremitätenbereich der Erhalt der Extremität mit möglichst geringen Funktionseinbußen im Vordergrund [17,18] rend Resektionen mit Sicherheitsabstän-den von >1 cm im Rumpf-und proximalen Extremitätenbereich in der Regel ohne signifikanten Funktionsverlust und oft ohne Weichgewebsrekonstruktion erzielt werden können, werden die Sicherheitsabstände unter der Prämisse des Funktionserhalts an den distalen Extremitäten-abschnitten und gerade an der Hand wiederholt unterschritten. Wichtigstes Ziel bleibt auch in diesen Lokalisationsbereichen die onkologisch gerechte Resektion (R0-Resektion) [16].…”