Superficial Siderosis of the Central Nervous System with Sexual Dysfunction as the First Symptom and a Method Preventing Worsening: A Case with 11 Years of Follow-ups

Zhan, Jian; Yu, Chunhao; Zuo, Houjuan

doi:10.4103/0028-3886.359295

Cited by 1 publication

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“…2 Chan et al found that cognitive impairment occurred in 50% of patients, and the degree of cognitive dysfunction was significantly correlated with the course of the disease. 11 Other rare symptoms include urinary incontinence or retention (24%), olfactory dysfunction (17%), 12 paresthesia (13%), sexual dysfunction (<10%), 13 and vestibular dysfunction (<10%). 14 Hearing loss is the most common and earliest symptom of SSCNS and is characterized by prodromal tinnitus, sensorineural hearing loss, and deafness within 15 years.…”

Section: Discussionmentioning

confidence: 99%

A case report of superficial siderosis of the central nervous system and literature review

Huang,

Xie,

Chen

et al. 2023

J Int Med Res

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Superficial siderosis of the central nervous system (SSCNS) is a rare disease characterized by iron deposition on the tissue surface of the middle axis system. We report the case of a man in his late 40 s who was admitted to the hospital with ataxia. A physical examination revealed cerebellar ataxia, sensorineural deafness, and bilateral pyramidal tract injury. Susceptibility-weighted magnetic resonance imaging showed linear hypointense signals on the surface of the cerebral hemispheres, sulcus gyrus, lateral ventricles, and cerebellum. The patient underwent treatment with deferiprone, mecobalamin, and vitamin B1, and the symptoms were not aggravated. The patient’s daily living ability was near normal after 1 year of follow-up. A literature review indicated that most SSCNS patients present diverse clinical manifestations. Clinicians may consider SSCNS in patients with hearing impairment and gait ataxia, especially for those receiving anticoagulant therapy and with a history of brain injury or accident.

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