“…Superficial Siderosis (SS) of Central Nervous System (CNS) was first reported by Hamill in 1908 as "melanosis of the brain". With approximately three hundred cases reported in literature, this disorder results in chronic or intermittent bleeding in subarachnoid space that leads to the deposition of blood subproducts in the leptomeninges (arachnoid and pia mater) (Ryu et al, 2016;Vilaça et al, 2015;Offenbacher et al, 1996). The presence of hemoglobin in these sites, which leads to the synthesis of Research, Society and Development, v. 10, n. 11, e270101119579, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i11.19579 2 ferritin and hemosiderin, is toxic and results in proliferation of microglia and neuronal injury (Sighary, Cohen-Addad & Linder, 2018;Koeppen et al, 2008).…”