Superficial CD34 positive fibroblastic tumor: report of three cases and review of the literature

Abstract

Superficial CD34 positive fibroblastic tumor (SCPFT) is a recently recognized, unique neoplasm with distinctive histomorphological features such as high pleomorphism, low mitotic rate, and diffuse CD34 reactivity. Hereby we present three cases of our experience with clinicopathological, morphological, and immunohistochemical characteristics. The patients were a 31-year-old female, 53-year-old female, and 33-year-old male. The tumors were all superficially located; left forearm, medial aspect of the left ankle, and left thigh, respectively. Histomorphologically they had expansile and focal infiltrative growth pattern consisting of highly pleomorphic spindle cells with intranuclear inclusions, yet low mitotic rate. Tumoral cells showed strong and diffuse reactivity for CD34. One of our cases showed focal and weak reactivity for pancytokeratin. Unlike the other two tumors, one case was positive for desmin. During the clinical follow-up, one case showed local recurrence four times. SCPFT is a newly recognized, borderline mesenchymal neoplasm of soft tissues that can show local recurrence or even rarely metastasize. To the best of our knowledge, this three case series is the first to be reported from Turkey. Our aim to report these three cases was to make contribution to the literature about this rare entity and increase awareness.

Superficial CD34‐positive fibroblastic tumor and PRDM10‐rearranged soft tissue tumor are overlapping entities: a comprehensive study of 20 cases

“…Following the initial description in 2014 by Carter et al, 1 several case-series of SCD34FT have been reported, validating the consistent clinicopathological characteristics of these neoplasms. [9][10][11][12] Subsequently, the description of recurrent fusions involving PRDM10 in tumors showing a close resemblance to SCD34FT opened the debate of whether they should be classified as independent entities. In this context, based on the available clinicopathological findings (Table 5), we believe there is compelling evidence for considering these neoplasms as part of the same spectrum.…”

Superficial CD34 Positive Fibroblastic Tumour, A Mesenchymal Tumour with Borderline Malignant Potential: A New Entity

“…Both SCD34FT and DFSP can exhibit pleomorphism with CD34-positivity in tumour cells, but DFSP shows a distinctive storiform pattern of spindle cells infiltrating into the subcutaneous tissue. [3,8] Areas with fibrosarcomatous transformation show a typical herringbone pattern with obvious mitotic figures and reduced CD34 expression. There is significantly increased p53 and Ki-67 expression.…”

Tumor fibroblástico inguinal superficial positivo para CD34. Reporte de un caso y revisión de la literatura

“…They are usually circumscribed lesions with subcutaneous presentation, with little or no deep-muscle involvement, as in our case. [1][2][3][4][5][6][7][8][9] The first case was described by Carter et al 3 in 2014, and, to date, 52 cases have been identified. [1][2][3] The literature presents only case reports, which makes it difficult to establish a treatment guide or clear evidence regarding surgical management and adjuvant modalities, such as chemotherapy or radiotherapy, for this type of tumor.…”

“…[1][2][3][4][5][6][7][8][9] The first case was described by Carter et al 3 in 2014, and, to date, 52 cases have been identified. [1][2][3] The literature presents only case reports, which makes it difficult to establish a treatment guide or clear evidence regarding surgical management and adjuvant modalities, such as chemotherapy or radiotherapy, for this type of tumor. However, the available information reveals good outcomes after surgical resection, with no postoperative local recurrences.…”