Superficial Leiomyosarcoma of the Glans: Report of a Case and Literature Review

Cigna, Emanuele; Maruccia, Michele; Parisi, Paola; Soda, Giuseppe; Nasca, Maria Rita; Micali, Giuseppe; Scuderi, Nicolò

doi:10.1007/s00266-013-0199-9

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…In comparison to superficial LMS, deep LMS located below the deep fascia of the penis are more likely to manifest with hematuria and urethral obstruction ( 10 ). The most frequent location of tumor was the shaft, followed by the prepuce, whereas the coronal sulcus, the frenulum, and circumcision scars were additional uncommon locations ( 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of penile malignant tumors (95%) are squamous cell carcinoma, while adenocarcinoma, malignant melanoma, and sarcoma are sporadic ( 1 ). Malignant mesenchymal tissue tumors (including Kaposi’s sarcoma, smooth muscle sarcoma, rhabdomyosarcoma, and malignant fibrous histiocytoma) account for less than 5%, among which primary leiomyosarcoma (LMS) of the penis is incredibly uncommon, mostly affecting middle-aged and older males ( 2 ). In 1969, Pratt and Ross ( 3 ) first classified LMS of the penis into deep and superficial types according to the tumor site.…”

Section: Introductionmentioning

confidence: 99%

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Case report and literature review: Primary leiomyosarcoma of the penis

Hao

Li²,

Lü³

et al. 2023

Front. Surg.

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BackgroundLeiomyosarcoma (LMS) is a malignant spindle-cell mesenchymal tumor originating from the smooth muscle cells, which mostly affects soft tissues and abdominopelvic organs over extremities. Primary LMS of the penis is a relatively uncommon mesenchymal tissue disease and a poorly understood condition.Case ReportA 69-year-old man presented with a growing, painless mass protruding from the penis. The irregularly lobulated lump was roughly 3 cm × 2.5 cm, with a smooth surface, tough texture, distinct boundary, and no tenderness. It was determined to be a penile tumor during the preoperative radiological evaluation. The patient underwent resection of the penile mass, followed by extended resection in the second operation. The diagnosis of LMS was verified by pathological examination. During a 20-month follow-up, the patient made a smooth recovery and remained disease-free.ConclusionAn immunohistochemical examination is essential for rendering this rare diagnosis. Radical excision of tumor lesions with negative cut margins is guaranteed to be the best treatment for primary penile LMS. Close follow-up should be provided due to the high rate of local recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Case report and literature review: Primary leiomyosarcoma of the penis

Hao

Li²,

Lü³

et al. 2023

Front. Surg.

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“…The first case of penile leiomyosarcoma was described by Levi in 1930 ( 1 ). The total number of superficial leiomyosarcoma reported cases was 30 in 2013 ( 6 ), and although current data regarding the exact number of cases superficial and deep are disparate, there are certainly fewer than 60 cases reported to date ( 7 – 9 ).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the lesion was located in the glans. Of a total of 30 cases leimyosarcoma superficial reviewed, in only 3 cases, it occurred exclusively in the glans ( 6 ). As in our case, the three cases of glans tumors did not show recurrence or metastasis.…”

Section: Discussionmentioning

confidence: 99%

Primary Leiomyosarcoma of the Glans

et al. 2022

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Penile leiomyosarcoma isz an extremely uncommon entity that rarely occurs in the glans. Due to the limited number of cases described in literature, guidelines regarding non-surgical treatment, prognosis, and management remain equivocal. Among the mesenchymal tumors of the penis, leiomyosarcoma has the highest propensity for recurrence. It originates in the smooth muscle cells from two distinct locations: superficial and deep. The deep subtype is the most aggressive and has the highest potential for metastasis. Surgical treatment should be implemented early and must be locally aggressive. Herein, we present a rare case of a 54-year-old patient with deep localized leiomyosarcoma of the glans, albeit with superficial characteristics. A review of the main histopathological, clinical, immunohistochemical, and therapeutic aspects of this unusual entity is presented.

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“…Occasionally, leiomyosarcoma presents as a lobulated, firm, reddish mass in the glans. [ 3 ] Whereas, in the prepuce and shaft, it presents as a subcutaneous tumor with good mobility, comparable to that of atheroma, leiomyoma, and schwannoma. Here, an ultrasound revealed intratumoral blood flow.…”

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confidence: 99%