Superficial Granulomatous Pyoderma gangrenosum of the Face, Successfully Treated by Ciclosporine: A Long-Term Follow-Up

Lachapelle, Jean‐Marie; Jabłońska, Stefania

doi:10.1159/000051624

Cited by 31 publications

(28 citation statements)

References 9 publications

(12 reference statements)

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“…Central cribriform scars and sinus tracts may be recognized.The lesions tended to occur on the sites of trauma, including those of surgical treatment.They tend to occur on the trunk rather than on the extremities in contrast to classic PG. This characteristic pattern of GP was diagnosed as SGP (1) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). In parallel, 13 cases of SGP including our patients have been reported in Japan (15)(16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 72%

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

Kaneko

Tamai

Yamazaki

et al. 2003

The Journal of Dermatology

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Superficial granulomatous pyoderma (SGP) is an unusual variant type of pyoderma gangrenosum characterized by a benign course and specific histological features; it is quite a rare cutaneous disorder in Japan. We reported two Japanese cases of SGP and compared the clinical features of 13 Japanese cases with those of 42 foreign cases. Case 1 was a 53-year-old female who presented with three indolent and ulcerative plaques with elevated edges on the back and the posterior portion of the left thigh. Case 2 was a 74-year-old female who presented with crusted and vegetative erythematous plaques on the left shoulder and left upper arm. Histological examinations revealed a characteristic three-layer granuloma in each case. Laboratory and physical examinations found no abnormalities. Topical corticosteroid, oral administration of minocycline, and/or additional supplementation with corticosteroid were effective. In comparison with foreign cases, Japanese cases show a possible differentiation in the ratio of sex and distribution of the ulcer. Females have a high incidence and the extremities are frequently involved area in Japanese cases. Up to now, 11 cases of SGP have been reported in Japan. To our best knowledge, our patients are the first Japanese cases described in the English literature.

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Section: Discussionmentioning

confidence: 72%

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

Kaneko

Tamai

Yamazaki

et al. 2003

The Journal of Dermatology

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“…This woman developed a PG on the right cheek after re-excision and closure of a biopsy scar, suggesting that pathergy plays a role. Another paper reported on a 44-year-old woman who developed PG on the forehead and the left temporal area without any prior trauma or associated pathologies [6]. In both cases, the diagnosis of superficial granulomatous pyoderma (SGP) was made.…”

Section: Discussionmentioning

confidence: 99%

Facial Pyoderma Gangrenosum in Senescence

et al. 2013

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“…Un bref traitement avec des corticostéroïdes per os, de la dapsone ou de la minocycline est prescrit dans les PG peu étendus, réfractaires aux traitements topiques ou intra-lésionnels. Pour les PG étendus ou agressifs, les corticostéroïdes per os ou la ciclosporine (seuls ou associés) semblent avoir été efficaces dans de nombreux cas [19,37,49,74] et devraient être considérés comme traitement de première intention (recommandations de grade B) [69]. La corticothérapie en pulse (méthylprednisolone IV) peut être utilisée comme traitement alternatif pour favoriser les rémissions (recommandations de grade B) [69].…”

Section: Prise En Charge Du Pgunclassified

Pyoderma gangrenosum (1^èrepartie) : mise au point

Chariatte

Lysitsa

Lombardi³

et al. 2011

Med Buccale Chir Buccale

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(Reçu le 18 janvier 2011, accepté le 8 mars 2011)Mots clés : pyoderma gangrenosum / dermatoses neutrophiliques / pathologies associées Résumé -Le pyoderma gangrenosum (PG) est une affection rare, se traduisant par une ou plusieurs ulcération(s) aseptique(s), à fond purulent, à bords surélevés et sous-minés, ayant une extension rapide et une évolution chronique. Il existe plusieurs formes cliniques mais l'aspect fait souvent évoquer une infection subaiguë ou chronique ; la recherche initiale de germes est toujours négative mais il y a souvent une surinfection. Le PG qui est rattaché aux dermatoses neutrophiliques est souvent associé à des pathologies spécifiques et il évolue en général parallèlement à l'affection associée. La prise en charge du PG commence donc par le traitement de cette dernière. Pour le PG lui-même, de nombreux traitements ont été proposés mais les corticoïdes et la ciclosporine constituent en général le traitement de première intention.Key words: pyoderma gangrenosum / neutrophilic dermatoses / associated pathologies Abstract -Pyoderma gangrenosum. Part I: literature review. Pyoderma gangrenosum (PG) is a rare non infectious neutrophilic dermatosis, characterized by one or many sterile painful ulcer(s), with a purulent base, raised and undermined edges; it has a rapid extension and a chronic evolution. There are several clinical forms, but the appearance is often suggestive of a subacute or a chronic infection; the initial search for microorganisms is always negative but secondary infection occurs frequently. PG is often associated with specific diseases and it generally evolves in parallel to the associated condition. Management of PG therefore begins by treating the underlying disorder. For the PG itself, many treatments have been proposed, but corticosteroids and cyclosporine are the first-line treatment.Le pyoderma gangrenosum (PG) est une affection rare qui se traduit cliniquement par une ou plusieurs ulcérations douloureuses ayant une bordure inflammatoire avec des clapiers purulents. Leur extension est rapide et leur évolution chronique. Le PG est maintenant rattaché aux dermatoses neutrophiliques.La description princeps a été réalisée par Louis Brocq en 1908 sous le terme de « phagédénisme géométrique ». Le terme phagédénisme (φάγειν, manger ;άδην, abondamment) a été proposé pour décrire des ulcérations qui ont tendance à s'étendre en surface et en profondeur [48]. En 1930, Brunsting, Goeckermann et O'Leary lui donnèrent son appellation actuelle. Ils décrivirent des ulcérations nécrotiques, extensives, douloureuses, à bords bleutés et sous-minés, entourées d'une aréole érythémateuse chez 5 patients, dont 4 étaient atteints d'une rectocolite ulcéreuse [13]. Ils pensaient que cette pathologie était liée à une infection. Des études ultérieures ont élargi le concept clinique du PG et identifié d'autres maladies associées. Dans la plupart des cas, le PG est associé avec une maladie intestinale inflammatoire

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Superficial Granulomatous Pyoderma gangrenosum of the Face, Successfully Treated by Ciclosporine: A Long-Term Follow-Up

Cited by 31 publications

References 9 publications

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

Facial Pyoderma Gangrenosum in Senescence

Pyoderma gangrenosum (1^èrepartie) : mise au point

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Superficial Granulomatous Pyoderma gangrenosum of the Face, Successfully Treated by Ciclosporine: A Long-Term Follow-Up

Cited by 31 publications

References 9 publications

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

Superficial Granulomatous Pyoderma: A Case Report of Two Japanese Patients and Clinical Comparison with Foreign Patients

Facial Pyoderma Gangrenosum in Senescence

Pyoderma gangrenosum (1èrepartie) : mise au point

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Pyoderma gangrenosum (1^èrepartie) : mise au point