Superficial granulomatous pyoderma accompanied with ulcerative colitis successfully treated with tacrolimus ointment

Systematic review: IBD-associated pyoderma gangrenosum in the biologic era, the response to therapy

“…A positive history of recent trauma was reported in seven cases . Only one case had systemic signs of infection with PG onset and responded clinically to antibiotics.…”

“…Of the nine, six had infliximab . Of the other three, two required the addition of topical tacrolimus or mesalazine to oral steroids. The third had stoma closure after combination therapy of ciclosporin + mesalazine + topical steroids .…”

Superficial granulomatous pyoderma in a patient with ulcerative colitis successfully treated with cyclosporine A

“…Two more Japanese case reports can be found. In addition, cases with underlying paraproteinemia, chronic renal failure, rheumatoid arthritis, Behçet's disease, osteomyelitis, and chronic lymphocytic leukemia have been reported in the literature . Despite the fact that tetracyclines are regarded to be sufficient treatment option of superficial granulomatous pyoderma, in the presented patient previous short‐term therapy with doxycycline failed to suppress the disease.…”

“…Superficial granulomatous pyoderma is considered to be a very rare, vegetative variant of pyoderma gangrenosum (PG). Less than 80 cases have been reported to date . Clinically, it is characterized by superficial vegetative ulcerations of a prolonged, rather benign course.…”

“…Moreover, superficial granulomatous pyoderma is considered to be rarely associated with systemic diseases. In the English literature, superficial granulomatous pyoderma in association with UC has been reported only once, in a Chinese patient, and it was successfully treated with topical tacrolimus . Two more Japanese case reports can be found.…”