Superficial Esophageal Neoplasms Overlying Leiomyomas Removed by Endoscopic Submucosal Dissection: Case Reports and Review of the Literature

Seo, Myeong Sook; Kim, Do Hoon; Cho, Young Whan; Gong, Eun Jeong; Lee, Sunpyo; Choi, Eun Ji; Jung, Hwoon Yong; Kim, Jin Ho

doi:10.5946/ce.2015.48.4.322

Cited by 7 publications

(8 citation statements)

References 15 publications

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“…As a result, 15 cases in 14 reports were elucidated. These reports were evaluated and summarized in Table 2 according to the originated country and published year of case report, patient's gender, age, chief complaints, risk factors, and comorbid diseases, and upper GI endoscopy, EUS, other diagnostic modalities and pathologic results, location of tumor and treatments applied (1,2,4,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…Leiomyoma of esophagus is rare, but it's the most common benign submucosal mesenchymal tumor (SMT) of the esophagus; it originates in the smooth muscle cells, and accounts for two-thirds (60-70%) of all benign esophageal tumors (1)(2)(3). It almost appears as a single tumor, and multiple leiomyomas of the esophagus are extremely rare (1,4). Since esophageal leiomyoma is generally a slow-growing tumor and the size of tumor may not change for many years, most affected patients are asymptomatic (2).…”

Section: Introductionmentioning

confidence: 99%

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Esophageal Leiomyoma and Simultaneous Overlying Squamous Cell Carcinoma: A Case Report and Review of the Literature

Mehrabi

Barhaghtalab

Hejazinia

et al. 2020

Preprint

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Abstract Background: Squamous cell carcinoma is the most common epithelial tumor of the esophagus. Upper endoscopy with multiple minimally invasive biopsies should be performed to confirm the diagnosis. Leiomyoma of esophagus is rare, but it’s the most common benign submucosal mesenchymal tumor of the esophagus. The simultaneous occurrence of an overlying epithelial lesion and a mesenchymal lesion is very rare. This study aims to show a case operated due to squamous cell carcinoma of esophagus that was postoperatively diagnosed with coexistent esophageal leiomyoma and provide a clear overview of the existing literature on it. Case presentation: The patient was a 41-year-old lady who underwent three field esophagectomy (McKeown). In reviewing the pathology slides, the patient had poorly differentiated squamous cell carcinoma and also multiple leiomyomas. A leiomyoma was coexisted with an invading overlying squamous cell carcinoma. Conclusion: It is concluded that esophageal carcinomas may coexist with leiomyomas; preexisting benign tumors may have played an important role in the development of carcinoma by inducing constant stimulation of the overlying mucosa; endoscopic ultrasonography is recommended to avoid overestimating the extent of tumor invasion and the resultant aggressive radical surgery; and esophageal resection is still the modality of choice in treatment in developing countries and also countries with limited equipment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Esophageal Leiomyoma and Simultaneous Overlying Squamous Cell Carcinoma: A Case Report and Review of the Literature

Mehrabi

Barhaghtalab

Hejazinia

et al. 2020

Preprint

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“…The relationship between GIST and LMS is unclear, especially in terms of causality. In the esophagus, squamous cell carcinoma overlying LMS has been reported . One hypothesis explaining this phenomenon is that the chronic stimulation of the epithelium over the pre‐existing LMS may induce the epithelial carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…In the esophagus, squamous cell carcinoma overlying LMS has been reported. 15 One hypothesis explaining this phenomenon is that the chronic stimulation of the epithelium over the pre-existing LMS may induce the epithelial carcinogenesis. So, in this case, the chronic stimulation of the muscularis mucosa over the preexisting GIST might induce the development of LMS.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of gastrointestinal stromal tumor and leiomyosarcoma of the stomach presenting as a collision tumor: A case report and review of literature

Kitagawa

Kaneko

Kano

et al. 2018

Pathology International

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Collision tumor of the stomach is rare. We report a rare case of a gastric collision tumor consisting of gastrointestinal stromal tumors (GISTs) and leiomyosarcoma (LMS). Computed tomography scan revealed a 15 cm sized mass in the posterior wall of the body of the stomach. Gross examination of the wedge resection specimen showed the tumor located in the muscularis propria with extramural protrusion into the peritoneal cavity and the gastric cavity with geographic necrosis, hemorrhage, and mucosal ulceration. Histologically, the majority of the tumor consisted of the GIST component and the minor area in the submucosal region consisted of the LMS component. The tumor showed an abrupt transition between GIST and LMS by histologically and immunohistochemically, suggesting a collision tumor. Furthermore, the GIST components exhibited a c-kit exon 11 mutation. On the other hand, LMS component exhibited neither c-kit nor platelet-derived growth factor receptor-alpha (PDGFRA) mutation. Here we describe a case of the collision tumor consisting of GIST and LMS and its literature review.

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“…Although esophageal leiomyoma is rare, it's the most common benign submucosal mesenchymal tumor (SMT) of the esophagus, originates from the cells of the smooth muscle, and form near the two-thirds (60-70%) of all benign tumors of the esophageal [1][2][3]. It almost appears as a single tumor, and multiple leiomyomas of the esophagus are extremely rare [1,4]. Since esophageal leiomyoma is generally a slow-growing tumor and the size of the tumor may not change for many years, most affected patients are asymptomatic [2].…”

Section: Introductionmentioning

confidence: 99%

Esophageal leiomyoma and simultaneous overlying squamous cell carcinoma: a case report and review of the literature

et al. 2021

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Background Squamous cell carcinoma is the most common epithelial tumor of the esophagus. Upper endoscopy with multiple minimally invasive biopsies should be performed to confirm the diagnosis. Leiomyoma of esophagus is rare, but it’s the most common benign submucosal mesenchymal tumor of the esophagus. The simultaneous occurrence of an overlying epithelial lesion and a mesenchymal lesion is very rare. This study aims to show a case operated due to squamous cell carcinoma of esophagus that was postoperatively diagnosed with coexistent esophageal leiomyoma and give a clear overview of the existing literature on it. Case presentation The patient was a 41-year-old woman who underwent three field esophagectomy (McKeown). Pathological evaluation was done, and the patient had poorly differentiated squamous cell carcinoma and multiple leiomyomas. A leiomyoma was found with an invading overlying squamous cell carcinoma. Conclusion It is concluded that esophageal carcinomas may coexist with leiomyomas; preexisting benign tumors may have played an important role in the development of the carcinoma by inducing constant stimulation of the overlying mucosa; endoscopic ultrasonography is recommended to avoid overestimating the extent of tumor invasion and the resultant aggressive radical surgery. As the developing countries had limited equipment, esophageal resection could be the modality of choice in the treatment.

show abstract

Superficial Esophageal Neoplasms Overlying Leiomyomas Removed by Endoscopic Submucosal Dissection: Case Reports and Review of the Literature

Cited by 7 publications

References 15 publications

Esophageal Leiomyoma and Simultaneous Overlying Squamous Cell Carcinoma: A Case Report and Review of the Literature

Esophageal Leiomyoma and Simultaneous Overlying Squamous Cell Carcinoma: A Case Report and Review of the Literature

Coexistence of gastrointestinal stromal tumor and leiomyosarcoma of the stomach presenting as a collision tumor: A case report and review of literature

Esophageal leiomyoma and simultaneous overlying squamous cell carcinoma: a case report and review of the literature

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