Superficial Dermal Fillers with Hyaluronic Acid

Bacos, Jonathan T; Dayan, Steven H.

doi:10.1055/s-0039-1688797

Cited by 25 publications

(57 citation statements)

References 38 publications

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“…An ideal filler should be effective in shaping and volumizing, long-lasting, biocompatible, safe, and low in cost. Hyaluronic acid (sodium hyaluronate, SH), which is currently the most widely used filler, is effective and safe [ 2 ], but it is also expensive per volume and not long-lasting [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate as a Potential Therapeutic Filler: An In Vivo Study in Rats

et al. 2020

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Filler injection demand is increasing worldwide, but no ideal filler with safety and longevity currently exists. Sodium alginate (SA) is the sodium salt of alginic acid, which is a polymeric polysaccharide obtained by linear polymerization of two types of uronic acid, d-mannuronic acid (M) and l-guluronic acid (G). This study aimed to evaluate the therapeutic value of SA. Nine SA types with different M/G ratios and viscosities were tested and compared with a commercially available sodium hyaluronate (SH) filler. Three injection modes (onto the periosteum, intradermally, or subcutaneously) were used in six rats for each substance, and the animals were sacrificed at 4 or 24 weeks. Changes in the diameter and volume were measured macroscopically and by computed tomography, and histopathological evaluations were performed. SA with a low M/G ratio generally maintained skin uplift. The bulge gradually decreased over time but slightly increased at 4 weeks in some samples. No capsule formation was observed around SA. However, granulomatous reactions, including macrophage recruitment, were observed 4 weeks after SA implantation, although fewer macrophages and granulomatous reactions were observed at 24 weeks. The long-term volumizing effects and degree of granulomatous reactions differed depending on the M/G ratio and viscosity. By contrast, SH showed capsule formation but with minimal granulomatous reactions. The beneficial and adverse effects of SA as a filler differed according to the viscosity or M/G ratio, suggesting a better long-term volumizing effect than SH with relatively low immunogenicity

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Section: Introductionmentioning

confidence: 99%

Sodium Alginate as a Potential Therapeutic Filler: An In Vivo Study in Rats

et al. 2020

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“… 9 In addition to between-product differences in grades of BDDE cross-linking and HA raw materials, each HA dermal filler product has unique physical characteristics that influence rheology and can potentially affect performance and safety. 5 , 9 , 34 – 36 As more HA dermal filler products are introduced into the global appearance medicine market, clinicians are encouraged to be familiar with the characteristics and appropriate uses of the different HA fillers. 14 The 4 BDDE-cross-linked HA dermal fillers used in our 2 studies have comparable formulations, but the BDDE cross-linking technology used in the manufacture of YC and YV is different to that used in the manufacture of RES and PER.…”

Section: Discussionmentioning

confidence: 99%

“…6 Hyaluronic acid (HA)–based fillers are the most popular choice of dermal fillers. 7 – 9 HA is a normal component of most tissues, including the dermis, 10 and HA-based fillers provide structural properties similar to those of native tissue and have excellent biocompatibility and good tissue integration. 11 The facial artery branches in the region of the NLF, in most cases, are located in the subcutaneous layer on the surface of facial muscles; therefore, it is best to place the injection into the NLF in a more superficial plane, that is, dermal or immediately subdermal.…”

Section: Introductionmentioning

confidence: 99%

“…A variety of HA products have been developed and are now commercially available, each with different rheological properties that allow for the treatment of problems ranging from superficial wrinkles to deep folds. 6 , 9 , 15 The HA concentration, type and level of cross-linking, and particle size affect the properties of the final product. 16 Increased HA concentration prolongs its longevity, but by itself is not the most important factor.…”

Section: Introductionmentioning

confidence: 99%

“… 5 , 11 HA particle size and viscoelasticity influence the performance of HA dermal filler products and their suitability in different situations, with larger particle products best suited to fill deep facial folds and smaller particle products more suitable for more moderate folds. 5 , 9 In addition, the elastic modulus G′, which is used to describe the hardness of a gel, also affects the performance of HA dermal fillers, and products with lower G′ are suited in an area of thinner and softer skin, 5 and products with a higher G′ have a more volumizing effect and also require deeper placement. 16 The deeper location of fillers allows for more gel injection with a larger bore needle and improves the effect of wrinkle correction, 17 which also increases de novo collagen synthesis as a result of fibroblast stretching, replacing the HA, resulting in longer-lasting correction.…”

Section: Introductionmentioning

confidence: 99%

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Two Randomized Controlled Trials of Hyaluronic Acid Fillers for the Correction of Nasolabial Folds

Yang

Shin

Lee

2020

Plastic and Reconstructive Surgery - Global Open

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Background: YVOIRE Classic s (YC) and Restylane (RES) have similar rheological properties, which suit mid-dermis injection, while the rheological properties of YVOIRE Volume s (YV) are comparable to those of Perlane (PER), which suit deep dermis injection to treat deep wrinkles. Two similarly designed studies aimed to evaluate the performance and safety of YC and YV injected into the nasolabial folds (NLFs). Methods: These were split-face designed, evaluator-blind, noninferiority studies. Fifty-eight subjects with moderate-to-severe NLFs were enrolled in the first study and treated with YC and RES, and 57 subjects were enrolled in the second study and treated with YV and PER. The Wrinkle Severity Rating Scale ranged from 1 (no visible fold) to 5 (extremely deep and long folds), and subject satisfaction was evaluated. Results: The least squares mean Wrinkle Severity Rating Scale scores (standard error) at week 26 were 2.56 (0.09) for both YC- and RES-treated NLFs and 2.89 (0.08) and 2.91 (0.08) for YV- and PER-treated NLFs, respectively. The difference between the groups was 0 and 0.02, and the lower limit of its 95% confidence interval was −0.0725 and −0.0125, which was greater than the predefined margin (−0.29), proving the noninferiority of YC and YV to RES and PER, respectively. The safety profiles and subject satisfaction of YC and YV were similar to those of RES and PER, respectively. Conclusion: YC is comparable to RES and YV is comparable to PER in terms of performance and safety profiles, with NLF-correcting effects lasting for up to 26 weeks.

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Dermal fillers: History 101

Andrews

Shope

Snyder

et al. 2023

Dermatological Reviews

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Introduction: Dermal fillers are an efficacious option for treating age-related volume deficiency, as well as scars and wrinkles. Additionally, they are useful for facial sculpting and contouring, and to augment anatomical structures such as the lips.Discussion: The start of the search for an ideal dermal filler can be traced back to the late 1800s. Characteristics of this ideal filler product include nontoxic, nonmigratory, noncarcinogenic, easily applied, noninfectious, painless, and longlasting. It would also have predictable and consistent results, feel natural, and require no patient downtime. Over the past century and a half, numerous products have been used or developed in an attempt to achieve a filler possessing these characteristics. However, only in the past few decades have safe, injectable filler products approved by the US Food and Drug Administration (FDA), been developed. Herein, we discuss the various injectable agents used in the past, as well as the most commonly used agents of present day. Conclusion:Reflecting upon the history of dermal filler development serves as an important reminder to proceed with caution, as serious complications may occur with their use. Importantly, no single filler is ideal for all patients or indications, therefore optimal treatment requires awareness of the properties and characteristics of each available product, and discretionary use by providers.

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Superficial Dermal Fillers with Hyaluronic Acid

Cited by 25 publications

References 38 publications

Sodium Alginate as a Potential Therapeutic Filler: An In Vivo Study in Rats

Sodium Alginate as a Potential Therapeutic Filler: An In Vivo Study in Rats

Two Randomized Controlled Trials of Hyaluronic Acid Fillers for the Correction of Nasolabial Folds

Dermal fillers: History 101

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