Superficial cryotherapy versus topical psoralen and ultraviolet A in the treatment of alopecia areata: a randomized, controlled trial

Sayed, Doaa S.; Allam, Aliaa A; Abdel-Majid, Ensaf M

doi:10.4103/jewd.jewd_7_20

Cited by 3 publications

(7 citation statements)

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“…When the overall clinical response was considered to be than 25% terminal hair regrowth according to Abdel-Majid et al, 25 group (1) patients had an overall clinical response of 72.5%, which was quite similar to that of 74% reported by Sayed et al, 26 and 73.3%…”

Section: Discussionsupporting

confidence: 59%

“…None of group (1) responders encountered recurrence of AA, in contrast to recurrence rates of 6.7%, 15%, and 41% reported by Jun and Lee, 24 Sayed et al, 26 and Gita and Mohammadreza 20 ; respectively. This could be explained by conducting 3 freeze–thaw cycles of DMEP compared with 2 cycles by Gita and Mohammadreza, 29 and longer freeze time of 5 s compared with 2–3 s in the study of Sayed et al 26 …”

Section: Discussioncontrasting

confidence: 54%

“…In group (1), 15/40 (37.5%) patients achieved an excellent response, which was higher than a 23% obtained by Gita and Mohammadreza, 20 25% by Abdel‐Majid et al, 25 33.3% by Sayed et al, 26 and Amirnia et al 27 reported a complete response of 90%–100% terminal hair regrowth in 23.3% of 120 patients after 4 sessions of liquid nitrogen each of 2 cycles of 3–5 s each.…”

Section: Discussionmentioning

confidence: 66%

“…On the other hand, Lei et al, 30 reported more than 60% hair regrowth in 70/72 (97.2%) of the patients. Zawar and Karad, 28 reported a good response in 8/10 (80%) of the patients, which could be due to longer freeze time, and Sayed et al, 26 reported a good response in 62.9% of 27 patients using liquid nitrogen spray in 3–4 freeze–thaw cycles of 2–3 s each; which could be due to smaller size of AA patches.…”

Section: Discussionmentioning

confidence: 96%

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Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single‐blinded randomized clinical trial

Aboeldahab

Nada

Assaf

et al. 2021

Dermatologic Therapy

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To verify and compare the therapeutic efficacy and safety of superficial cryotherapy using dimethyl ether and propane (DMEP) mixture vs. microneedling in the treatment of mild scalp alopecia areata (AA). In a prospective randomized single‐blinded clinical trial, 80 patients with clinically evident scalp mild AA were randomly assigned into two groups of 40 patients each. Group (1) was treated by superficial cryotherapy using DMEP in three freeze–thaw cycles of 5 s each. Group (2) was treated by microneedling. Both groups were treated every 2 weeks for 6 sessions and followed up for 3 months after the last session. Patients were assessed by photographic documentation, trichoscopic evaluation, severity of alopecia tool (SALT) score, and alopecia areata symptom impact scale (AASIS). An excellent response was achieved in 15 (37.5%) of group (1) compared with 14 (35%) of group (2) patients, while a good response was achieved in 23 (57.5%) of group (1) compared with 21 (52.5%) of group (1) patients, with a statistically insignificant difference. The mean SALT score change percentage was a statistically significantly higher in group (2) patients. The mean AASIS change percentage was higher in group (1) patients, but this was a statistically insignificant. In both groups, the mean numbers of trichoscopic signs of AA significantly decreased from baseline to the end of follow‐up period. Both therapeutic modalities were well‐tolerated, with no recurrence after the follow‐up period. Both superficial cryotherapy using DMEP mixture, and microneedling are simple, effective, and safe therapeutic options for mild scalp AA, however, microneedling showed higher efficacy.

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Section: Discussionsupporting

confidence: 59%

Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 96%

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Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single‐blinded randomized clinical trial

Aboeldahab

Nada

Assaf

et al. 2021

Dermatologic Therapy

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“…Conventional treatments of AA include intralesional steroid, photochemotherapy, and systemic steroid therapy. Cryotherapy can also be useful in the treatment of AA (10) .…”

Section: Discussionmentioning

confidence: 99%

Superficial Cryotherapy Versus Intralesional Corticosteroid Injection In Alopecia Areata: A Comparative Clinical And Dermoscopic Study

Mohammed¹,

Farag²,

Hafiz³

2022

The Egyptian Journal of Hospital Medicine

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Background: Alopecia areata (AA) is a common, non-scarring type of hair loss, affecting approximately 2.1% of the population. Many modalities of treatment are recommended like steroid injection, topical Immunotherapy, and several systemic therapies, but none of them can prevent or alter the course of the disease with variable degrees of improvement. Objective: To evaluate efficacy and safety of superficial cryotherapy versus intralesional corticosteroid injection in the treatment of alopecia areata. Patients and Methods: Thirty patients aged 14-58 years, with localized multiple patchy alopecia areata (at least two patches), were enrolled in this study. In each patient, one patch was treated by superficial cryotherapy via liquid nitrogen spray. This involved two treatment cycles/sessions, each lasting 3-5 seconds. The other patch was treated with intralesional steroid injection (triamcinolone acetonide 5 mg/ml, 0.1ml /cm 2 . Sessions were repeated every three weeks up to three months. The target lesions were evaluated clinically using SALT score and by 2 blinded dermatologists and dermoscopically at baseline, every session, and the end of the study (one month after the last session). Results: At the end of the study, the clinical response (number of the patients with hair growth > 20%) to superficial cryotherapy was about 83.3% (25 patients out of 30 patients). While in the steroid group the clinical response was about 80% (24 patients out of 30 patients). There was a statistically significant reduction in SALT score and dermoscopic parameters at the end of the study in both groups with no significant difference between them. There was a significant clinico-dermoscopic relation between hair regrowth and dermoscopic findings. Conclusion: Superficial cryotherapy is an effective and safe therapeutic modality for AA with advantages of simplicity and noninvasiveness.

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Treatments for alopecia areata: a network meta-analysis

Mateos-Haro,

Novoa-Candia,

Sánchez Vanegas

et al. 2023

Cochrane Database of Systematic Reviews

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Superficial cryotherapy versus topical psoralen and ultraviolet A in the treatment of alopecia areata: a randomized, controlled trial

Cited by 3 publications

References 0 publications

Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single‐blinded randomized clinical trial

Superficial cryotherapy using dimethyl ether and propane mixture versus microneedling in the treatment of alopecia areata: A prospective single‐blinded randomized clinical trial

Superficial Cryotherapy Versus Intralesional Corticosteroid Injection In Alopecia Areata: A Comparative Clinical And Dermoscopic Study

Treatments for alopecia areata: a network meta-analysis

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