Superficial Chemosurgery in Treating Aging Skin

Ayres, Samuel

doi:10.1001/archderm.1962.01590030083011

Cited by 64 publications

(26 citation statements)

References 7 publications

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“…Litton [26] verwendete Glyzerin anstatt Septisol, um eine größere Haltbarkeit der Lösung zu erzielen. Zur selben Zeit verglich Ayres [3] erstmals die histologischen Verände-rungen nach TCA-Peels mit denjenigen nach Phenol-Peels.…”

Section: Entwicklung Der Peeltechnikenunclassified

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Chemical Peels in der �sthetischen Dermatologie

Wiest¹

2004

Hautarzt

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Chemical peels are classified as very superficial (exfoliation), superficial (epidermal), medium (papillary dermal) and deep (reticular dermal). A successful peel depends upon a number of variables, such as choice of the peeling agent, its concentration, and the pressure and frequency of the applications; all must be adjusted to the patient's skin condition. Through standardization of the peeling agents, the level of injury can be determined pre-operatively and complications minimized. Trichloroacetic acid (TCA) is the most popular peeling agent used in different concentrations. It has the broadest spectrum of indications due to its versatility in combination with other peeling agents. Indications for superficial peels include skin resurfacing, wrinkles, actinically damaged skin, actinic keratoses and benign pigmented lesions. Superficial peels have the advantage that they can be used on most regions of the body. The use of different chemical peels, their varying effects and their potential complications are reviewed. There are at present more than 45 chemical peels with different combinations of agents available on the European market.

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Section: Entwicklung Der Peeltechnikenunclassified

“…Das heute noch am populärsten tiefe Chemical Peel wird mit einer von Baker und Gordon 1961 [3] beschriebenen Rezeptur (⊡ Tabelle 6) für eine phenolhaltige Peellösung durchgeführt, die bis ins mittlere Stratum reticulare eindringt.…”

Section: Phenolunclassified

Chemical Peels in der �sthetischen Dermatologie

Wiest¹

2004

Hautarzt

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“…Using a scale of 1 to 9, the change in photodamage scores seen with laser resurfacing usually averages about 50%. (17) The amount of change seen with a 30% TCA peel has been shown to be around 25%. The healing time and risks associated with the laser procedure may be slightly greater, but are not parallel with the enhanced benefit, which is far greater.…”

Section: Figmentioning

confidence: 99%

“…(2) The first of these techniques to be developed was chemical peeling. (10)(11)(12)(13)(14)(15)(16)(17)(18) This procedure, developed in Egyptian times, utilizes various acids and/or combination of acids to exfoliate the sun-damaged epidermis with the production of a subepidermal layer of scar that minimizes wrinkling. Unfortunately, for this technique to be effective, the patient must undergo pain associated with epidermal and superficial dermal destruction and then a number of days of erythema, edema, and exfoliation while the epidermis reforms.…”

Section: Introductionmentioning

confidence: 99%

Reversal of Photoaging in 10 Weeks: A Novel Skin Peeling System with a Uniquely Formulated Postpeel Regimen

Fitzpatrick¹,

Goldman²,

Butterwick³

2001

International Journal of Cosmetic Surgery and Aesthetic Dermato

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The aging of the "baby boomers" as well as the successful development of various resurfacing modalities have created an increased demand for procedures or products that may reverse photoaging. A consideration for those people desiring such improvement is the amount of time to be devoted to healing of the skin. A unique skin-care system oriented toward reversal of photoaging plus a unique superficial peel combining alpha hydroxy, beta hydroxy, and retinoic acids is discussed and evaluated in 10 patients with biopsies and clinical evaluation after 10 weeks. An average improvement in photo-aging scores of about 12% was seen as well as 22% thickening of the epidermis and a 50% increase in Grenz zone collagen. 199

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“…TCA is a peeling agent popularized by Ayres [3]. It produces epidermal and dermal necrosis without serious systemic toxicity and displays potential local side effects as hypopigmentation, persistent erythema and, most importantly, scarring.…”

Section: Introductionmentioning

confidence: 99%

Comparative Caustic and Biological Activity of Trichloroacetic and Glycolic Acids on Keratinocytes and Fibroblasts in vitro

Rakić¹,

Lapière²,

Nusgens³

2000

Skin Pharmacol Physiol

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Objectives: Beside their causticity, the biological mechanism by which trichloroacetic acid (TCA) and glycolic acid (GA), two agents extensively used for chemical peeling, might act remains unknown. The purpose of this study was to examine in vitro the effect of TCA and GA on human keratinocytes and the influence of the released epithelial mediators on collagen and matrix metalloproteinases (MMPs) production by human dermal fibroblasts. Method: Cultured keratinocytes were treated by TCA and GA at 10 mg/ml brought to pH 3, 5 and 7, and the conditioned media neutralized to pH 7 were added to human normal skin fibroblasts. Results: TCA was cytotoxic for keratinocytes at each tested pH. The conditioned medium depressed protein and collagen synthesis and the expression of MMPs when added to fibroblasts as did also TCA when added directly to fibroblasts. GA was not cytotoxic for keratinocytes at neutral pH and the conditioned medium obtained at each pH applied to fibroblasts did not alter protein, collagen nor MMPs production while causing an elevated secretion of IL-6. Conclusion: TCA exerts a toxic effect on keratinocytes and fibroblasts while GA does not alter the metabolism of fibroblasts but induces the secretion of IL-6.

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Superficial Chemosurgery in Treating Aging Skin

Cited by 64 publications

References 7 publications

Chemical Peels in der �sthetischen Dermatologie

Chemical Peels in der �sthetischen Dermatologie

Reversal of Photoaging in 10 Weeks: A Novel Skin Peeling System with a Uniquely Formulated Postpeel Regimen

Comparative Caustic and Biological Activity of Trichloroacetic and Glycolic Acids on Keratinocytes and Fibroblasts in vitro

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