Superficial cervico-vaginal myofibroblastoma: a report of five cases

Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region

“…MFB of the lower female genital tract is a benign stromal tumor occurring in the subepithelial stroma of the vagina and, less frequently, of the vulva and cervix [18][19][20][21]. Although a classic-type MFB of this area consists of ovoid-to spindle-or stellate-shaped cells, usually arranged in a reticular, lacelike, or sieve-like pattern [18][19][20][21], tumors with a predominant spindle cell component, closely reminiscent of mammary MFB, have been reported recently [21].…”

“…Although a classic-type MFB of this area consists of ovoid-to spindle-or stellate-shaped cells, usually arranged in a reticular, lacelike, or sieve-like pattern [18][19][20][21], tumors with a predominant spindle cell component, closely reminiscent of mammary MFB, have been reported recently [21]. Like mammary MFB, MFB of the lower female genital tract variably expresses desmin, CD34, bcl-2 protein, CD10, CD99, and estrogen receptor/progesterone receptor [18][19][20][21]. These findings led us to speculate about the possibility that these lesions may be derived from a common precursor mesenchymal cell of the hormonally responsive stroma [21,22].…”

Vulvovaginal myofibroblastoma: expanding the morphological and immunohistochemical spectrum. A clinicopathologic study of 10 cases

“…The term superficial cervicovaginal myofibroblastoma (MFB) or superficial MFB of the lower female genital tract has been used interchangeably in the literature to refer to this entity that characteristically arises from the subepithelial stroma of the vagina and, less frequently, of the vulva and cervix [1][2][3]. This tumor clinically presents as a polypoid or nodular mass of variable size (2-65 mm) in women ranging in age from 23 to 80 years [1][2][3]. Interestingly, a significant number of these patients had been taking tamoxifen, suggesting the possibility of a hormone-related pathogenesis [1,2].…”

Vaginal superficial myofibroblastoma: a rare mesenchymal tumor of the lower female genital tract and a study of its association with viral infection

“…Only one tumor recurred locally 9 years after incomplete excision. 3 Superfi cial cervicovaginal myofi broblastoma is relatively site specifi c and has distinct clinicopathological features that can be used to distinguish it from other mesenchymal tumors arising in the lower female genital tract.…”

“…1 To the best of our knowledge, fewer than 35 cases have been documented in the English literature. [1][2][3][4][5][6][7] The exact etiology of this tumor remains unclear. For mesenchymal tumors, the association of viral infection and tumorigenesis has been well established in some types of soft tissue tumors.…”