Superelectrophilic Methylthiomethylation of Aromatics with Chloromethyl Methyl Sulfide/Aluminum Chloride (MeSCH₂Cl:2AlCl₃) Reagent

18F‐Labeling of Aryl‐SCF3, ‐OCF3 and ‐OCHF2 with [18F]Fluoride

“…This order combined with the observation that electron withdrawing groups on the aryl substituent of arylCF 2 Br precursors lead to significantly lower RCY, [17] suggests that cationic intermediates are involved in these Ag I -mediated 18 F-fluorinations. [24] Theidentification of arobust protocol for the isolation of 18 F-labeled products starting from circa 4GBq of radioactivity required further tuning since increased quantities of K 2 CO 3 and Kryptofix had ad etrimental effect on the RCY. These limitations were overcome using potassium oxalate [25] and dicyclohexyl-18-crown-6 [26] acting as an alternative base and [ 18 F]KF activator,r espectively.U sing these modified conditions,t he labeled products 2a ([ 18…”

18F‐Labeling of Aryl‐SCF3, ‐OCF3 and ‐OCHF2 with [18F]Fluoride

“…This order combined with the observation that electron withdrawing groups on the aryl substituent of arylCF 2 Br precursors lead to significantly lower RCY, [17] suggests that cationic intermediates are involved in these Ag I -mediated 18 F-fluorinations. [24] Theidentification of arobust protocol for the isolation of 18 F-labeled products starting from circa 4GBq of radioactivity required further tuning since increased quantities of K 2 CO 3 and Kryptofix had ad etrimental effect on the RCY. These limitations were overcome using potassium oxalate [25] and dicyclohexyl-18-crown-6 [26] acting as an alternative base and [ 18 F]KF activator,r espectively.U sing these modified conditions,t he labeled products 2a ([ 18 F]arylSCF 3 ), 4a ([ 18 F]arylOCF 3 ), 6b and 6f ([ 18 F]arylOCHF 2 )w ere isolated…”

Synthesis of hyperbranched polymers with controlled degree of branching

“…85 A number of diarylated syntheses catalyzed by a superacid has been reported in the literature. The protonation of the 1,2-dicarbonyl group, 62,96,97 aldehydes, 98,99 nitriles 100 and other systems [101][102][103][104][105] resulted in the formation of highly reactive dication intermediates, which are sufficiently condensed with aromatic compounds. 106 By applying this concept, Zolotukhin et al 107 recently reported that a linear poly(phenylene ether) with a high MW was prepared by polycondensation of 2,2,2-trifluoroacetophenone with 4,4¢-diphenoxybenzophenone in TFSA at room temperature.…”