Supercritical processing of starch aerogels and aerogel-loaded poly(ε-caprolactone) scaffolds for sustained release of ketoprofen for bone regeneration

Goimil, Leticia; Braga, Mara E.M.; Dias, Ana M.A.; Gómez-Amoza, J.L.; Concheiro, Ángel; Álvarez-Lorenzo, Carmen; Sousa, Hermínio C. de; García‐González, Carlos A.

doi:10.1016/j.jcou.2017.01.028

Cited by 87 publications

(54 citation statements)

References 51 publications

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“…Other supercritical foaming modifications not requiring downstream processes are under research. Namely, the use of organic solvents [118,119], biofunctional plasticizers [114], or the incorporation of aerogels from different sources [120][121][122][123] in synthetic scaffolds processed by supercritical foaming promoted the formation of more interconnected porous structures with larger pores. The pore interconnectivity can be also modulated by modifications on the venting rate [124].…”

Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

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The regenerative medicine field is seeking novel strategies for the production of synthetic scaffolds that are able to promote the in vivo regeneration of a fully functional tissue. The choices of the scaffold formulation and the manufacturing method are crucial to determine the rate of success of the graft for the intended tissue regeneration process. On one hand, the incorporation of bioactive compounds such as growth factors and drugs in the scaffolds can efficiently guide and promote the spreading, differentiation, growth, and proliferation of cells as well as alleviate post-surgical complications such as foreign body responses and infections. On the other hand, the manufacturing method will determine the feasible morphological properties of the scaffolds and, in certain cases, it can compromise their biocompatibility. In the case of medicated scaffolds, the manufacturing method has also a key effect in the incorporation yield and retained activity of the loaded bioactive agents. In this work, solvent-free methods for scaffolds production, i.e., technological approaches leading to the processing of the porous material with no use of solvents, are presented as advantageous solutions for the processing of medicated scaffolds in terms of efficiency and versatility. The principles of these solvent-free technologies (melt molding, 3D printing by fused deposition modeling, sintering of solid microspheres, gas foaming, and compressed CO2 and supercritical CO2-assisted foaming), a critical discussion of advantages and limitations, as well as selected examples for regenerative medicine purposes are herein presented.

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Section: Compressed Co 2 and Supercritical Co 2 -Assisted Foamingmentioning

confidence: 99%

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

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“…Starch aerogel microspheres loaded with ketoprofen drug were incorporated into poly( -caprolactone) (PCL) scaffolds made by supercritical CO 2 foaming. These highly porous scaffolds showed good mechanical properties, water permeability, cell infiltration capacity, and ketoprofen release in vitro over 3 days [80].…”

Section: Polysaccharide Scaffoldsmentioning

confidence: 99%

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

et al. 2019

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Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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“…Starch, being a widely abundant native biopolymer, has attracted attention of the aerogel research: Mehling et al [14], Marco et al [15], Ubeyitogullari and Ciftci [16], De Marco and Reverchon [17] and Goimil et al [18] produced starch aerogel with specific surface areas between 60 and 100 m 2 /g. Higher values between 220 and 254 m 2 /g have been reported by Garcia-Gonzalez et al [19] and Druel et al [20].…”

Section: Introductionmentioning

confidence: 99%

Production of starch aerogel in form of monoliths and microparticles

et al. 2020

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Pea and amylomaize starches were used to produce aerogel in form of monoliths and microparticles. The formation of starch gel was investigated, and we showed that each starch needed a different pasting temperature for its complete dissolution. The gelation kinetics was investigated with oscillatory rheometry for both systems as a function of the starch concentration. The gelation and retrogradation temperature of the starch gel were varied and its impact on the final aerogel evaluated. The emulsion gelation was carried out batch wise in a stirred vessel with different impeller geometries, concentrations of surfactant (Span80 and PGPR) and stirring rates. A particle size prediction approach based on idealized flow (Couette, 2D hyperbolic and turbulent) during the emulsification was proposed. A semi-continuous setup for the emulsion gelation was developed in which the emulsification occurs in a single pass through a colloid mill and the gelation is triggered in-line with a counter-current heat exchanger.

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Supercritical processing of starch aerogels and aerogel-loaded poly(ε-caprolactone) scaffolds for sustained release of ketoprofen for bone regeneration

Cited by 87 publications

References 51 publications

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

Production of starch aerogel in form of monoliths and microparticles

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