Supercritical processing of PCL and PCL-PEG blends to produce improved PCL-based porous scaffolds

Guastaferro, Mariangela; Baldino, Lucia; Cardea, Stefano; Reverchon, Ernesto

doi:10.1016/j.supflu.2022.105611

Cited by 16 publications

(15 citation statements)

References 42 publications

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“…The porosity was also estimated by gravimetric analysis using the bulk density method. 52 The volume of air within a material can be determined by using a correction parameter (K) calculated as the ratio between the apparent density (mass of the material divided by its volume) and the bulk density (density of the solid material). In this study, at least six specimens of each material were weighed and their sizes measured to obtain the air volume, V air , and porosity, P i , (eqs 4 4.…”

Section: Resultsmentioning

confidence: 99%

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Solution Blow Spun Poly(ethylene oxide)/Poly-ε-caprolactone System: Properties and Dissolution in Water

Lorente

González‐Gaitano

Valero

et al. 2023

ACS Appl. Polym. Mater.

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In the present work, fibrous materials based on poly(ethylene oxide) (PEO), poly-ε-caprolactone (PCL), and a mixture of them (PEO/PCL) have been prepared by solution blow spinning (SBS). The rotation speed of the collector of the SBS device (500, 1000, 1500, 2000, 2500, and 3000 rpm) has been chosen as the processing variable to modify the materials’ morphologies. The structures of the polymer systems have been evaluated by attenuated total reflectance Fourier transformed infrared spectroscopy and X-ray diffraction, and the morphologies have been inspected by field emission scanning electron microscopy, while thermal and mechanical behaviors have been studied by differential scanning calorimetry and tensile tests, respectively. Dissolution in water has been monitored by optical microscopy and video recording. As a proof of concept, the capacities of the systems under study to release a model drug have been tested by loading the materials with silver(I) sulfadiazine (SSD) and then immersing them in a buffer solution and monitoring the process through the intrinsic fluorescence of SSD. Our results indicate that there are no changes at the molecular level, but there is a change in the morphology of the material as a function of the rotation speed of the collector. These morphological variations, together with the composition of the system, affect the mechanical behavior of the material, the dissolution process in water, and the drug release. These factors are relevant if the blow spun material is intended for biomedical applications in which an active agent has to be released in a controlled manner.

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Section: Resultsmentioning

confidence: 99%

“…The porosity was also estimated by gravimetric analysis using the bulk density method . The volume of air within a material can be determined by using a correction parameter ( K ) calculated as the ratio between the apparent density (mass of the material divided by its volume) and the bulk density (density of the solid material).…”

Section: Resultsmentioning

confidence: 99%

Solution Blow Spun Poly(ethylene oxide)/Poly-ε-caprolactone System: Properties and Dissolution in Water

Lorente

González‐Gaitano

Valero

et al. 2023

ACS Appl. Polym. Mater.

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“…In particular, nanospheres made of biocompatible polymers have been widely studied for medicinal use, in which bioactive agents can release from the particle overtime 17–19 . PCL's hydrophobicity and flexibility can be increased by combining it with PEG, a flexible, inert, and biocompatible non‐ionic hydrophilic polyester that can prevent protein adsorption and is used in drug delivery and biomedicine 20,21 . PEG's degradation rate is quicker when used alone, but its lack of mechanical strength makes it unsuitable for use as an anti‐adhesion agent.…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19] PCL's hydrophobicity and flexibility can be increased by combining it with PEG, a flexible, inert, and biocompatible non-ionic hydrophilic polyester that can prevent protein adsorption and is used in drug delivery and biomedicine. 20,21 PEG's degradation rate is quicker when used alone, but its lack of mechanical strength makes it unsuitable for use as an anti-adhesion agent. Furthermore, its fiber spinnability is extremely low, mainly because the constituent particles are electrosprayed.…”

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confidence: 99%

Electrospray doxorubicin‐loaded polycaprolactone‐polyethylene glycol nanospheres/poloxamer‐chitosan thermogel: A promising candidate for clinical applications

Mehrazin,

Asefnejad,

Naeimi

et al. 2024

Polymers for Advanced Techs

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In recent years, polymer nanospheres have been considered as one of the most common materials in the drug delivery domain. In this research, polycaprolactone‐polyethylene glycol (PCL‐PEG) blend nanospheres were produced using the electrospray method to load doxorubicin. Also, these nanospheres can be used for injection in the treatment site by poloxamer‐chitosan thermogel. In this research, PCL and PEG were used as raw materials to produce nanospheres. Then, doxorubicin was used for loading in nanospheres. The electrospray method was chosen as the method of nanosphere production. In the next step, poloxamer‐chitosan thermogel was used for injection at the treatment site. In this method, Fourier transform infrared spectroscopy, scanning electron microscopy, and rheometer techniques were used to identify the compounds and properties of the obtained specimens. Also, the MTT test was used to investigate toxicity. The results showed that PCL‐PEG polymer nanospheres were produced by loading doxorubicin using the electrospraying method with a diameter of 185 ± 23 nm. Also, these nanospheres were used for injection in the treatment site using poloxamer‐chitosan thermogel. The amount of drug release in the PLX‐CS (DOX‐PCL‐PEG)NSs was 63% in 144 h at medium pH 5.5. In the drug release system, the in‐vitro method was utilized to study the release of PLX‐CS (DOX‐PCL‐PEG) NSs. PCL‐PEG nanospheres combined in poloxamer‐chitosan thermogel polymer showed the controlled release of doxorubicin, therefore, the evaluated drug release system is considered a valuable perspective as an efficient and safe route for drug delivery in the target tissue and treating various types of cancer. This research can be used as a new method in drug delivery systems.

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“…However, if the PEO's relative molecular weight exceeds a certain threshold, polymer degradation in the body is impossible [57]. Therefore, since PCL has a low melting temperature and good blending capabilities, melt blending with a polymer such as PEO would be a simple way to improve its properties and extend its use into a broader range of tissue engineering applications [36,60]. PCL is a biodegradable polyester with good mechanical properties, while PEO is a hydrophilic polymer that is water-soluble and biocompatible.…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Molecular Weight of Poly(Ethylene Oxide) on the Hydrolytic Degradation and Physical Properties of Polycaprolactone Binary Blends

Dalton

Ebrahimi

et al. 2023

Macromol

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The use of biodegradable polymers in tissue engineering has been widely researched due to their ability to degrade and release their components in a controlled manner, allowing for the potential regeneration of tissues. Melt blending is a common method for controlling the degradation rate of these polymers, which involves combining these materials in a molten state to create a homogenous mixture with tailored properties. In this study, polycaprolactone (PCL) was melt blended with hydrophilic poly (ethylene oxide) (PEO) of different molecular weights to assess its effect on PCL material performance. Hydrolytic degradation, thermal and viscoelastic properties, and surface hydrophilicity were performed to contrast the properties of the blends. DSC, DMA, and FTIR were performed on selected degraded PCL/PEO specimens following mass loss studies. The results showed that adding PEO to PCL reduced its melt viscosity-torque and melt temperature while increasing its hydrophilicity, optimizing PCL/PEO blend for soft tissue engineering applications and could contribute to the development of more effective and biocompatible materials for soft tissue regeneration.

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Supercritical processing of PCL and PCL-PEG blends to produce improved PCL-based porous scaffolds

Cited by 16 publications

References 42 publications

Solution Blow Spun Poly(ethylene oxide)/Poly-ε-caprolactone System: Properties and Dissolution in Water

Solution Blow Spun Poly(ethylene oxide)/Poly-ε-caprolactone System: Properties and Dissolution in Water

Electrospray doxorubicin‐loaded polycaprolactone‐polyethylene glycol nanospheres/poloxamer‐chitosan thermogel: A promising candidate for clinical applications

The Influence of the Molecular Weight of Poly(Ethylene Oxide) on the Hydrolytic Degradation and Physical Properties of Polycaprolactone Binary Blends

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