Supercritical impregnation as a feasible technique for entrapment of fat-soluble vitamins into alginate aerogels

Pantić, Milica; Knez, Željko; Novak, Zoran

doi:10.1016/j.jnoncrysol.2015.11.011

Cited by 81 publications

(32 citation statements)

References 26 publications

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“…Thus, the supercritical technology proved to be suitable to obtain controlled-release systems that potentially could be used as active layer of food package with enhanced properties. Moreover, there are numerous proofs in the literature that alginate is suitable matrix for encapsulation of bioactive substances such as vitamins [253], proanthocyanidins [254], phytochemicals [255]. In addition, CO 2 supercritical drying provide their controlled release from aerogels in desired time.…”

Section: Alginatementioning

confidence: 99%

Prospect of Polysaccharide-Based Materials as Advanced Food Packaging

Nešić

Cabrera‐Barjas

Dimitrijević-Branković

et al. 2019

Molecules

208

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The use of polysaccharide-based materials presents an eco-friendly technological solution, by reducing dependence on fossil resources while reducing a product's carbon footprint, when compared to conventional plastic packaging materials. This review discusses the potential of polysaccharides as a raw material to produce multifunctional materials for food packaging applications. The covered areas include the recent innovations and properties of the polysaccharide-based materials. Emphasis is given to hemicelluloses, marine polysaccharides, and bacterial exopolysaccharides and their potential application in the latest trends of food packaging materials, including edible coatings, intelligent films, and thermo-insulated aerogel packaging.

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Section: Alginatementioning

confidence: 99%

Prospect of Polysaccharide-Based Materials as Advanced Food Packaging

Nešić

Cabrera‐Barjas

Dimitrijević-Branković

et al. 2019

Molecules

208

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“…1 and S3 in the Supporting Information. All samples display a similar open meso-and macroporous, sponge-like structure that is characteristic to alginate aerogels (Pantic et al, 2016;Robitzer, David, Rochas, Di Renzo, & Quignard, 2008a, 2008b. No major alterations can be discovered between the structures of the pristine and the loaded samples.…”

Section: Scanning Electron Microscopymentioning

confidence: 85%

“…Similarly to the hydrogels, these aerogels are versatile biomaterials which were recently introduced into the field of drug delivery research Veronovski, Novak, & Knez, 2012). The oral (Garcia-Gonzalez, Jin, Gerth, Alvarez-Lorenzo, Mehling, Smirnova, Guenther, & Neubert, 2009) and mucosal (Goncalves et al, 2016) delivery applications of various active pharmaceutical ingredients, including fat-soluble vitamins (Pantic, Knez, & Novak, 2016) have been investigated. Layered (Veronovski, Knez, & Novak, 2013) and core-shell (Ulker & Erkey, 2014) formulations have also been developed aiming to fine-tune the release kinetics.…”

Section: Introductionmentioning

confidence: 99%

A redox strategy to tailor the release properties of Fe(III)-alginate aerogels for oral drug delivery

Veres

Sebők

Dékány

et al. 2018

Carbohydrate Polymers

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Iron(III)-crosslinked alginate aerogel beads (d = 3-5 mm) were prepared and loaded with ibuprofen by using the technique of adsorptive deposition from supercritical CO 2 . Additional formulations were prepared where the aerogels were co-impregnated by ibuprofen and ascorbic acid. The release of ibuprofen from the Fe(III)-alginate is much faster in pH = 7.4 (PBS) than in pH = 2.0 (HCl), which can be explained by the faster dissolution and higher swelling of the alginate matrix in PBS. By decreasing the size of the beads and using a higher G content alginate the release rate could be slightly increased. A marked acceleration of drug release was achieved in both HCl and PBS by incorporating ascorbic acid into the Fe(III)-alginate aerogel preparations. The explanation is that in aqueous media ascorbic acid in situ reduces the crosslinking Fe(III) to Fe(II). The latter does not interact strongly with alginate, which promotes the hydration of the chains, thus the erosion and dissolution of the carrier matrix.

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“…Cellulose aerogels were produced by SC-CO2 drying at 120 ± 5 bar and 40°C. The procedure employed is similar to the method described elsewhere [25,27] where the drying was done in 3 cycles of CO2 flow, each one lasting 2 h. At the end of each cycle, the extracted ethanol was collected and fresh CO2 was introduced. After completing the total period of 6 h of SC drying, the system was depressurized at rate of 2 bar/min to avoid shrinkage of cellulose aerogels.…”

Section: Supercritical Dryingmentioning

confidence: 99%

Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol

Lopes

Mustapa

Pantić

et al. 2017

The Journal of Supercritical Fluids

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The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m 2 g-1 , pore volume from 0.3 to 2.4 cm 3 g-1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was 2 investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40°C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry.

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Supercritical impregnation as a feasible technique for entrapment of fat-soluble vitamins into alginate aerogels

Cited by 81 publications

References 26 publications

Prospect of Polysaccharide-Based Materials as Advanced Food Packaging

Prospect of Polysaccharide-Based Materials as Advanced Food Packaging

A redox strategy to tailor the release properties of Fe(III)-alginate aerogels for oral drug delivery

Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol

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