Supercritical fluids extraction of Ginkgo ginkgolides and flavonoids

Chiu, Kou-Lung; Cheng, Yong; Chen, Junhao; Chang, Chieh-Ming J.; Yang, Po

doi:10.1016/s0896-8446(02)00014-1

Cited by 98 publications

(45 citation statements)

References 22 publications

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“…It is important to note that, the solubility of analytes in a solid matrix in supercritical fluid extraction is a major factor determining the extraction efficiency. The solubility is generally controlled by the volatility of substance, which is a function of temperature and solvation effect of the supercritical fluid, which is a function of fluid density [18,19]. Therefore, it is difficult to predict the effect of temperature.…”

Section: Analysis Of Response Surfacementioning

confidence: 99%

“…The co-solvent improves SC-CO 2 extractability by increasing the polarity of solute in the sample. It has been observed that the addition of methanol [19] and ethanol can drastically increase the extraction of compound from plant matrices. In this study similar effect was observed in the effect of co-solvent (ethanol) flow rate.…”

Section: Analysis Of Response Surfacementioning

confidence: 99%

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Optimization of Extraction Condition for Supercritical Carbon Dioxide (SCCO 2) Extraction of Strobhilantes crispus (Pecah Kaca) Leaves by Response Surface Methodology

Md Salleh

2012

J Food Process Technol

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Supercritical carbon dioxide (SC-CO 2 ) extraction was used to obtain the bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca). Process variables namely pressure, temperature and co-solvent flow rate were studied for optimization of the extraction yield and bioactive flavonoid compound of S. crispus by response surface methodology following a Box Behnken design of experiments. HPLC was performed to determine the major bioactive flavonoid compounds from S. crispus. The optimum value of yield extraction (6.55%) was obtained at pressure 200 bar, 50°C temperature and co-solvent flow rate of 5 g/min. Under the optimum conditions, eight flavonoid compounds were identified namely (+)-catechin, (-) epicatechin, rutin, myricetin, luteolin, apigenin, naringenin and kaempferol. The experimental extraction yield is in good agreement with the predicted one. The response surface methodology used in this study was able to predict the optimal extraction conditions for the extraction yield of bioactive flavonoid compounds from S.crispus leaves extract.

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Section: Analysis Of Response Surfacementioning

confidence: 99%

Section: Analysis Of Response Surfacementioning

confidence: 99%

Optimization of Extraction Condition for Supercritical Carbon Dioxide (SCCO 2) Extraction of Strobhilantes crispus (Pecah Kaca) Leaves by Response Surface Methodology

Md Salleh

2012

J Food Process Technol

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show abstract

“…On one hand, higher temperature can accelerate fluid flow and thus increase the solute of compounds; on the other hand, higher temperature can decrease fluid density and thus reduce extraction efficiency. The overall extraction effect of supercritical fluids usually follows the competition between the increasing in solute of compounds and the reduction in SC-CO 2 density due to the rise in temperature (Chiu et al, 2002).…”

Section: Effect Of Temperature On the Yield Of Flavonoidsmentioning

confidence: 99%

Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulusL.)

Hao-ping

Chen

et al. 2005

J. Zhejiang Univ. Sci.

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Waste hops are good sources of flavonoids. Extraction of flavonoids from waste hops (SC-CO 2 extracted hops) using supercritical fluids technology was investigated. Various temperatures, pressures and concentrations of ethanol (modifier) and the ratio (w/w) of solvent to material were tested in this study. The results of single factor and orthogonal experiments showed that at 50 °C, 25 MPa, the ratio of solvent to material (50%), ethanol concentration (80%) resulted in maximum extraction yield flavonoids (7.8 mg/g). HPLC-MS analysis of the extracts indicated that flavonoids obtained were xanthohumol, the principal prenylflavonoid in hops.

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“…Over 30 flavonoids, including flavonol glycosides, flavonols, flavones, biflavones and catechins, have been isolated from G. biloba leaves [1]. G. biloba flavonoids have been prescribed for sensitivity-related chronic cerebral deterioration and functional disturbances, as well as cerebral vascular accidents and cranial trauma [2]. Recently, increasing attention has been directed to G. biloba flavonoids, due to their various antiinflammatory and antitumor activities [3,4].…”

Section: Introductionmentioning

confidence: 99%

Selective extraction of flavonoids from Ginkgo biloba leaves using human serum albumin functionalized magnetic nanoparticles

Ren

Xue

Liang

et al. 2013

Chinese Chemical Letters

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Supercritical fluids extraction of Ginkgo ginkgolides and flavonoids

Cited by 98 publications

References 22 publications

Optimization of Extraction Condition for Supercritical Carbon Dioxide (SCCO 2) Extraction of Strobhilantes crispus (Pecah Kaca) Leaves by Response Surface Methodology

Optimization of Extraction Condition for Supercritical Carbon Dioxide (SCCO 2) Extraction of Strobhilantes crispus (Pecah Kaca) Leaves by Response Surface Methodology

Optimization of conditions for supercritical fluid extraction of flavonoids from hops (Humulus lupulusL.)

Selective extraction of flavonoids from Ginkgo biloba leaves using human serum albumin functionalized magnetic nanoparticles

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