Supercritical fluid (SCF)-assisted preparation of cyclodextrin-based poly(pseudo)rotaxanes for transdermal purposes

Cardoso, Gleidson; González, Claudia Beatriz; Santos‐Rosales, Víctor; Taveira, Stephânia Fleury; Cunha-Filho, Marcílio; Alvarez‐Lorenzo, Carmen; Magariños, Beatríz; Marreto, Ricardo Neves

doi:10.1007/s13346-023-01385-w

Cited by 3 publications

References 44 publications

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Rambutan‐Like Mg−Bi−O : Fe Assemblies Loaded with Fomesafen Herbicide to Induce the Fast Germination of Pinto Bean Plants

Esquivel‐Castro,

Oliva,

Rosu

et al. 2024

ChemistrySelect

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Assemblies of magnesium and bismuth oxides (Mg−Bi−O) were synthesized with (MBO : Fe) and without iron (MBO) by using a hydrothermal method. Such assemblies were utilized to promote the germination and growth of pinto bean seedlings. The MBO : Fe assemblies had rambutan‐like morphology, which is composed by nanohairs/flagella. The MBO : Fe assemblies were loaded with fomesafen herbicide and the release kinetics of such herbicide was explained by using the Korsmeyer‐Peppas model and the non‐Fickian transport mechanism. The cumulative fomesafen release at pH 7.5 reached percentages of 4.38 %, 71.02 %, 75.04 %, and 100 % for the MBO, MBO‐1 % Fe, MBO‐3 % Fe, and MBO‐5 % Fe, respectively. Also, the MBO and MBO : Fe assemblies were utilized to promote the growth of pinto bean plants. The germination percentages for the MBO, MBO‐1 % Fe, MBO‐3 % Fe, and MBO‐5 % Fe samples were 83.33, 100, 91.67 and 100 %, respectively. Such percentages are higher than that for the control plants grown without MBO : Fe (66.67 %). The longest root/shoot lengths (20.62/48 cm) were obtained for the plant grown with the MBO‐3 % Fe assembly. In contrast, lower root/shoot lengths (14.7/30.66 cm) were obtained for the control plants. Thus, MBO : Fe assemblies loaded with fomesafen improved the physical characteristics of the bean plants, which is of interest for the sustainable agriculture.

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Rambutan‐Like Mg−Bi−O : Fe Assemblies Loaded with Fomesafen Herbicide to Induce the Fast Germination of Pinto Bean Plants

Esquivel‐Castro,

Oliva,

Rosu

et al. 2024

ChemistrySelect

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The implications of lipid mobility, drug-enhancers (surfactants)-skin interaction, and TRPV1 activation on licorice flavonoid permeability

Wang,

Chen,

Liang

et al. 2023

Drug Deliv. and Transl. Res.

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The implications of lipids mobility, drug-enhancers (surfactants)-skin interaction and TRPV1 on licorice flavonoids permeability

Wang,

Hu,

Xue

et al. 2023

Preprint

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Licorice flavonoids (LFs) attained a considerable interest in cosmetic and skin ailments treatments, however, their lipophilic nature restricts their application. In this paper, we systematically investigated the enhancement efficacy and mechanisms of different penetration enhancers (surfactants) on ten LFs compounds. Herein, the aim was to unveil how seven different enhancers modified the stratum corneum (SC) surface and influence the drug-enhancers-skin interaction, and to relate these effects to permeation enhancing effects of ten LFs compounds in the liquids. The enhancing efficacy was evaluated by ERpermeation, ERretention and ERcom, which was conducted on the porcine skin. It was summarized that heat capsaicin (CaP) and lipophilic Plurol® Oleique CC 497 (POCC) caused the most significance of SC lipids fluidity, SC water loss and surface structures alterations, thereby resulting in a higher permeation enhancing effects than other surfactants. Moreover, CaP could completely occupied drug-skin interaction sites, while POCC only occupied most drug-skin interactions. The enhancing efficacy of both POCC and capsaicin was dependent on the log P values of LFs. For impervious LFs with low drug solubility, enhancing their drug solubility helped them permeate into the SC interface. For high-permeation LFs, their permeation was hardly enhanced or inhibited ascribed to the strong drug-enhancer-skin strength in the SC. More importantly, drug-surfactant-skin energy possessed a good negative correlation with the LFs permeation amount for most LFs molecules. Additionally, transient receptor potential vanilloid 1 (TRPV1) rather than transient receptor potential melastatin 8 (TRPM8) mediated LFs permeation enhancement by capsaicin. The study provided novel insights for drug permeation enhancement from the viewpoint of molecular pharmaceutics, as well as the scientific utilization of LFs compounds and surfactants in topical or transdermal formulations.

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Supercritical fluid (SCF)-assisted preparation of cyclodextrin-based poly(pseudo)rotaxanes for transdermal purposes

Cited by 3 publications

References 44 publications

Rambutan‐Like Mg−Bi−O : Fe Assemblies Loaded with Fomesafen Herbicide to Induce the Fast Germination of Pinto Bean Plants

Rambutan‐Like Mg−Bi−O : Fe Assemblies Loaded with Fomesafen Herbicide to Induce the Fast Germination of Pinto Bean Plants

The implications of lipid mobility, drug-enhancers (surfactants)-skin interaction, and TRPV1 activation on licorice flavonoid permeability

The implications of lipids mobility, drug-enhancers (surfactants)-skin interaction and TRPV1 on licorice flavonoids permeability

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