Supercritical fluid processing of proteins: lysozyme precipitation from aqueous solution

Abstract

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Probiotics - What They Are, Their Benefits and Challenges

“…This microencapsulation technique is based on the formation of an interpolymer complex between poly (vinyl pyrrolidone) (PVP) and poly (vinyl acetate-co-crotonic acid) (pVA-CA) in supercritical carbon dioxide (scCO 2 ). A supercritical substance is neither a gas nor a liquid but possesses properties of both, making it unique (Moshashaee et al, 2000). Since supercritical fluids have a wide spectrum of solvent characteristics, they can be used as solvents in different techniques (Frederiksen et al, 1997).…”

Physical Properties of Supercritically-Processed and Micronised Powders for Respiratory Drug Delivery

“…The SEDS™ method (Solution Enhanced Dispersion By Supercritical Fluids) [6] has an added advantage of very fast, homogeneous nozzle mixing between supercritical antisolvent and drug solution leading to consistent production of micron sized particulate products [7]. By changing the working conditions of pressure, temperature, solution concentration and flow rates, it is possible to control the size, shape, morphology and crystal form of the micron sized particles [2,[7][8][9]. In studies with DPI formulations of salbutamol sulphate, increased FPF and targeted in vitro delivery have been demonstrated for SEDS -prepared powders when compared with micronised material [10,11].…”

Raman characterization and chemical imaging of biocolloidal self-assemblies, drug delivery systems, and pulmonary inhalation aerosols: A review

“…117 It was reported 136 that SEDS-produced lysozyme retained biological activity as a respirable solid particle while exhibiting minor changes in its FT-Raman spectra.…”